The Concept of an Ideal Antibiotic: Implications for Drug Design

Novel β-lactam-β-lactamase inhibitor combinations: expectations for the treatment of carbapenem-resistant Gram-negative pathogens

(2019) Ilias Karaiskos et al.   Expert Opinion on Drug Metabolism & Toxicology

Cytochrome P450 Structure, Function and Clinical Significance: A Review

(2018) Palrasu Manikandan et al.   CURRENT DRUG TARGETS

Overcoming problems of poor drug penetration into bacteria: challenges and strategies for medicinal chemists

(2018) Davide Benedetto Tiz et al.   Expert Opinion on Drug Discovery

Pediatric Exclusivity and Regulatory Authority

(2018) Jeanie Kim et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Developments in strategies for Quorum Sensing virulence factor inhibition to combat bacterial drug resistance

(2018) Shafiul Haque et al.   MICROBIAL PATHOGENESIS

OUP accepted manuscript

(2018)   CLINICAL INFECTIOUS DISEASES

Antibacterial resistance and the success of tailored triple therapy in Helicobacter pylori strains isolated from Slovenian children

(2017) Tita Butenko et al.   HELICOBACTER

Evaluation of combinations of putative anti-biofilm agents and antibiotics to eradicate biofilms of Staphylococcus aureus and Pseudomonas aeruginosa

(2017) Katherine Belfield et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Update on Antimicrobial Resistance in Clostridium difficile: Resistance Mechanisms and Antimicrobial Susceptibility Testing

(2017) Zhong Peng et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Antibiotic Use in Children – A Cross-National Analysis of 6 Countries

(2017) Ilan Youngster et al.   JOURNAL OF PEDIATRICS

Selenazolinium Salts as “Small Molecule Catalysts” with High Potency against ESKAPE Bacterial Pathogens

(2017) Karolina Witek et al.   MOLECULES

New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria

(2017) Gabriella Spengler et al.   MOLECULES

Engineering of obligate intracellular bacteria: progress, challenges and paradigms

(2017) Erin E. McClure et al.   NATURE REVIEWS MICROBIOLOGY

Persistent bacterial infections and persister cells

(2017) Robert A. Fisher et al.   NATURE REVIEWS MICROBIOLOGY

Comparative Study of Clarithromycin- versus Metronidazole-Based Triple Therapy as First-Line Eradication for Helicobacter pylori

(2017) Teppei Adachi et al.   ONCOLOGY

The Role of Reactive Oxygen Species in Antibiotic-Mediated Killing of Bacteria

(2017) Heleen Van Acker et al.   TRENDS IN MICROBIOLOGY

Delafloxacin: design, development and potential place in therapy

(2017) Francico Javier Candel et al.   Drug Design Development and Therapy

Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis

(2016) Ameeruddin Nusrath Unissa et al.   INFECTION GENETICS AND EVOLUTION

Antibacterial Derivatives of Marine Algae: An Overview of Pharmacological Mechanisms and Applications

(2016) Emer Shannon et al.   Marine Drugs

L-form bacteria, chronic diseases and the origins of life

(2016) Jeff Errington et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Antibiotic Adjuvants: Rescuing Antibiotics from Resistance

(2016) Gerard D. Wright   TRENDS IN MICROBIOLOGY

Antibiotic Resistance and Regulation of the Gram-Negative Bacterial Outer Membrane Barrier by Host Innate Immune Molecules

(2016) Samuel I. Miller   mBio

Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens

(2016) Sirijan Santajit et al.   Biomed Research International

Origin and Proliferation of Multiple-Drug Resistance in Bacterial Pathogens

(2015) Hsiao-Han Chang et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Tackling the threat of antimicrobial resistance: from policy to sustainable action

(2015) L. J. Shallcross et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Tuberculosis Treatment and Drug Regimens

(2015) G. Sotgiu et al.   Cold Spring Harbor Perspectives in Medicine

An Unsupported Preference for Intravenous Antibiotics

(2015) Ho Kwong Li et al.   PLOS MEDICINE

Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It

(2015) Helen I. Zgurskaya et al.   ACS Infectious Diseases

Helicobacter pylori in gastric carcinogenesis

(2015) Hyo Jun Ahn et al.   World Journal of Gastrointestinal Oncology

Antimicrobial susceptibility patterns of Ureaplasma species and Mycoplasma hominis in pregnant women

(2014) Mathys J Redelinghuys et al.   BMC INFECTIOUS DISEASES

Novel Formulations for Antimicrobial Peptides

(2014) Ana Carmona-Ribeiro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bacteriostatic versus bactericidal antibiotics for patients with serious bacterial infections: systematic review and meta-analysis

(2014) Johannes Nemeth et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Eliciting antibiotics active against the ESKAPE pathogens in a collection of actinomycetes isolated from mountain soils

(2014) H. Zhu et al.   MICROBIOLOGY-SGM

ND4BB: addressing the antimicrobial resistance crisis

(2014) John H. Rex   NATURE REVIEWS MICROBIOLOGY

Drug Development and FDA Approval, 1938–2013

(2014) Jonathan J. Darrow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery and preclinical development of new antibiotics

(2014) Diarmaid Hughes et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Engineered Endolysin-Based "Artilysins" To Combat Multidrug-Resistant Gram-Negative Pathogens

(2014) Y. Briers et al.   mBio

Anti-biofilm agents: recent breakthrough against multi-drug resistantStaphylococcus aureus

(2014) Pooi Y. Chung et al.   Pathogens and Disease

Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them

(2014) Leonard Amaral et al.   Frontiers in Pharmacology

Bacterial Persister Cell Formation and Dormancy

(2013) Thomas K. Wood et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Antibiotic resistance—the need for global solutions

(2013) Ramanan Laxminarayan et al.   LANCET INFECTIOUS DISEASES

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Cell Death from Antibiotics Without the Involvement of Reactive Oxygen Species

(2013) Y. Liu et al.   SCIENCE

Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species

(2013) I. Keren et al.   SCIENCE

Strategies to Minimize Antibiotic Resistance

(2013) Chang-Ro Lee et al.   International Journal of Environmental Research and Public Health

L-form bacteria, cell walls and the origins of life

(2013) J. Errington   Open Biology

Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

(2012) J. S. Brooke   CLINICAL MICROBIOLOGY REVIEWS

Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance

(2012) L. Fernandez et al.   CLINICAL MICROBIOLOGY REVIEWS

Microbial Efflux Pump Inhibition: Tactics and Strategies

(2012) George P. Tegos et al.   CURRENT PHARMACEUTICAL DESIGN

Pharmacokinetics and pharmacodynamics of ‘old’ polymyxins: what is new?

(2012) Phillip J. Bergen et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Bacteriophage endolysins as novel antimicrobials

(2012) Mathias Schmelcher et al.   Future Microbiology

Education of healthcare professionals and the public

(2012) C. A. M. McNulty et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Intracellular Vesicles as Reproduction Elements in Cell Wall-Deficient L-Form Bacteria

(2012) Yves Briers et al.   PLoS One

Novel classes of antibiotics or more of the same?

(2011) Anthony RM Coates et al.   BRITISH JOURNAL OF PHARMACOLOGY

An Unmet Medical Need: Rapid Molecular Diagnostics Tests for Respiratory Tract Infections

(2011)   CLINICAL INFECTIOUS DISEASES

Systemic Antibiotic Therapy for Chronic Osteomyelitis in Adults

(2011) B. Spellberg et al.   CLINICAL INFECTIOUS DISEASES

Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance

(2011) A.-P. Magiorakos et al.   CLINICAL MICROBIOLOGY AND INFECTION

EUCAST expert rules in antimicrobial susceptibility testing

(2011) R. Leclercq et al.   CLINICAL MICROBIOLOGY AND INFECTION

Assessment of Cytochrome P450 Enzyme Inhibition and Inactivation in Drug Discovery and Development

(2011) David O. Nettleton et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs

(2011) P. E. Almeida Da Silva et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis

(2011) W. Shi et al.   SCIENCE

Antimicrobial Actions of Reactive Oxygen Species

(2011) F. C. Fang   mBio

Contrasting Effects of Acidic pH on the Extracellular and Intracellular Activities of the Anti-Gram-Positive Fluoroquinolones Moxifloxacin and Delafloxacin againstStaphylococcus aureus

(2010) Sandrine Lemaire et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Use of Ichip for High-Throughput In Situ Cultivation of "Uncultivable" Microbial Species

(2010) D. Nichols et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Antibiotic chemotherapy during pregnancy and lactation period: aspects for consideration

(2010) Ioannis Mylonas   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

The 10 × ‘20 Initiative: Pursuing a Global Commitment to Develop 10 New Antibacterial Drugs by 2020

(2010)   CLINICAL INFECTIOUS DISEASES

Metronidazole Is Still the Drug of Choice for Treatment of Anaerobic Infections

(2010) Sonja Löfmark et al.   CLINICAL INFECTIOUS DISEASES

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Treatment with Monoclonal Antibodies againstClostridium difficileToxins

(2010) Israel Lowy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

(2010) L. Dethlefsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multidrug Resistance in Bacteria

(2009) Hiroshi Nikaido   Annual Review of Biochemistry

Infection with PanresistantKlebsiella pneumoniae:A Report of 2 Cases and a Brief Review of the Literature

(2009) Azza Elemam et al.   CLINICAL INFECTIOUS DISEASES

Colistin in the 21st century

(2009) Roger L Nation et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Outer membrane permeability and antibiotic resistance

(2008) Anne H. Delcour   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Requirements for a lead compound to become a clinical candidate

(2008) Franz F Hefti   BMC NEUROSCIENCE

Mycobacterium tuberculosis and the Macrophage: Maintaining a Balance

(2008) Jean Pieters   Cell Host & Microbe

Position Paper: Recommended Design Features of Future Clinical Trials of Antibacterial Agents for Community‐Acquired Pneumonia

(2008)   CLINICAL INFECTIOUS DISEASES

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Are natural products still the best source for antibacterial discovery? The bacterial entry factor

(2008) Lynn L Silver   Expert Opinion on Drug Discovery

Pandrug-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii infections: Characteristics and outcome in a series of 28 patients

(2008) Matthew E. Falagas et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY

Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology

(2008) Maxwell C. K. Leung et al.   TOXICOLOGICAL SCIENCES

The biology and future prospects of antivirulence therapies

(2007) Lynette Cegelski et al.   NATURE REVIEWS MICROBIOLOGY