Leukocyte arrest: Biomechanics and molecular mechanisms of β 2 integrin activation

Rap1 and its effector RIAM are required for lymphocyte trafficking

(2015) W. Su et al.   BLOOD

Gnb isoforms control a signaling pathway comprising Rac1, Plc 2, and Plc 3 leading to LFA-1 activation and neutrophil arrest in vivo

(2015) H. Block et al.   BLOOD

Mechanisms of integrin and filamin binding and their interplay with talin during early focal adhesion formation

(2015) Tiffany Truong et al.   Integrative Biology

Direct Interactions with the Integrin β1 Cytoplasmic Tail Activate the Abl2/Arg Kinase

(2015) Mark A. Simpson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1

(2015) M. Cote et al.   JOURNAL OF CELL SCIENCE

Blocking neutrophil integrin activation prevents ischemia–reperfusion injury

(2015) Tadayuki Yago et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional Beta2-Integrins Restrict Skin Inflammation In Vivo

(2015) Terhi S. Savinko et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

PIP2 and Talin Join Forces to Activate Integrin

(2015) Adam Orłowski et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A new mutation in theKINDLIN-3gene ablates integrin-dependent leukocyte, platelet, and osteoclast function in a patient with leukocyte adhesion deficiency-III

(2015) Roman Crazzolara et al.   PEDIATRIC BLOOD & CANCER

Integrin Cytoplasmic Tail Interactions

(2014) Elizabeth M. Morse et al.   BIOCHEMISTRY

Rap1-GTP-interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice

(2014) S. Stritt et al.   BLOOD

αVβ3 Integrin Regulation of Respiratory Burst in Fibrinogen Adherent Human Neutrophils

(2014) Hye-Yeong Kim et al.   Cellular and Molecular Bioengineering

The bullseye synapse formed between CD4+ T-cell and staphylococcal enterotoxin B-pulsed dendritic cell is a suppressive synapse in T-cell response

(2014) Wei Lin et al.   IMMUNOLOGY AND CELL BIOLOGY

An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2

(2014) Mehmet Sen et al.   JOURNAL OF CELL BIOLOGY

Talin and kindlin: the one-two punch in integrin activation

(2014) Feng Ye et al.   Frontiers of Medicine

Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling

(2013) J. M. Herter et al.   BLOOD

The  2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo

(2013) V. L. Morrison et al.   BLOOD

Crawling of effector T cells on extracellular matrix: role of integrins in interstitial migration in inflamed tissues

(2013) Chang H Kim   Cellular & Molecular Immunology

The Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3

(2013) Feng Ye et al.   CURRENT BIOLOGY

Leukocyte integrins αLβ2, αMβ2 and αXβ2 as collagen receptors—Receptor activation and recognition of GFOGER motif

(2013) Matti Lahti et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

(2013) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation

(2013) Alessio Montresor et al.   JOURNAL OF CELL BIOLOGY

The PSGL-1–L-selectin signaling complex regulates neutrophil adhesion under flow

(2013) Anika Stadtmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Integrin Regulation during Leukocyte Recruitment

(2013) J. Herter et al.   JOURNAL OF IMMUNOLOGY

Characterization of 14-3-3-ζ Interactions with Integrin Tails

(2013) Roman Bonet et al.   JOURNAL OF MOLECULAR BIOLOGY

Two modes of integrin activation form a binary molecular switch in adhesion maturation

(2013) Ho-Sup Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of kindlin-3 alters the threshold for NK cell activation in human leukocyte adhesion deficiency-III

(2012) R. Gruda et al.   BLOOD

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

(2012) C. T. Lefort et al.   BLOOD

A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion

(2012) Xianqiang Song et al.   CELL RESEARCH

Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts

(2012) Ronen Alon et al.   CURRENT OPINION IN CELL BIOLOGY

Numb/Numbl-Opo Antagonism Controls Retinal Epithelium Morphogenesis by Regulating Integrin Endocytosis

(2012) Ozren Bogdanović et al.   DEVELOPMENTAL CELL

Integrin signalling and function in immune cells

(2012) Yanbo Zhang et al.   IMMUNOLOGY

Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)α/β by Protein Kinase C (PKC)α and Akt Promotes Thrombin-mediated Integrin αIIbβ3Activation and Granule Secretion in Platelets

(2012) Samantha F. Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial Coordination of Kindlin-2 with Talin Head Domain in Interaction with Integrin β Cytoplasmic Tails

(2012) Kamila Bledzka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative regulators of integrin activity

(2012) J. Pouwels et al.   JOURNAL OF CELL SCIENCE

Protein Kinase C-  Is Required for Murine Neutrophil Recruitment and Adhesion Strengthening under Flow

(2012) A. Bertram et al.   JOURNAL OF IMMUNOLOGY

The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin β1 endocytosis

(2012) Anjali Teckchandani et al.   MOLECULAR BIOLOGY OF THE CELL

‘Slings’ enable neutrophil rolling at high shear

(2012) Prithu Sundd et al.   NATURE

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail

(2012) Ralph Thomas Böttcher et al.   NATURE CELL BIOLOGY

CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules

(2011) S. Kliche et al.   BLOOD

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

(2011) A. Zarbock et al.   BLOOD

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

(2011) A. V. Rubtsov et al.   BLOOD

Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of integrin affinity on cell surfaces

(2011) Thomas Schürpf et al.   EMBO JOURNAL

Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling

(2011) Anika Stadtmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis

(2011) Matthew MacPherson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration

(2011) Anja Mai et al.   JOURNAL OF CELL BIOLOGY

Kindlin-3–mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption

(2011) Sarah Schmidt et al.   JOURNAL OF CELL BIOLOGY

Leukocyte integrin activation and deactivation: novel mechanisms of balancing inflammation

(2011) Alexander Zarbock et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Molecular mechanism of inside-out integrin regulation

(2011) F. YE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

SHARPIN is an endogenous inhibitor of β1-integrin activation

(2011) Juha K. Rantala et al.   NATURE CELL BIOLOGY

Inactive-state preassembly of Gq-coupled receptors and Gq heterotrimers

(2011) Kou Qin et al.   Nature Chemical Biology

The neutrophil in vascular inflammation

(2011) Mia Phillipson et al.   NATURE MEDICINE

Multiscale simulations suggest a mechanism for integrin inside-out activation

(2011) A. C. Kalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

(2011) G. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tail of integrin activation

(2011) Nicholas J. Anthis et al.   TRENDS IN BIOCHEMICAL SCIENCES

Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils

(2010) Y. Kuwano et al.   BLOOD

E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin  L 2-mediated slow leukocyte rolling

(2010) T. Yago et al.   BLOOD

LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming

(2010) S. Balkow et al.   BLOOD

Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro

(2010) A. McDowall et al.   BLOOD

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC)  2 and PI3K  pathways

(2010) H. Mueller et al.   BLOOD

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

(2010) Benjamin T Goult et al.   EMBO JOURNAL

A Deadly Migration

(2010) Gabriela Constantin et al.   IMMUNITY

β1-Integrin-Collagen Interaction Suppresses FoxO3a by the Coordination of Akt and PP2A

(2010) Richard Seonghun Nho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds

(2010) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The kindlins at a glance

(2010) E. Karakose et al.   JOURNAL OF CELL SCIENCE

LFA-1 and Mac-1 Define Characteristically Different Intralumenal Crawling and Emigration Patterns for Monocytes and Neutrophils In Situ

(2010) R. Sumagin et al.   JOURNAL OF IMMUNOLOGY

P-Rex1 and Vav1 Cooperate in the Regulation of Formyl-Methionyl-Leucyl-Phenylalanine-Dependent Neutrophil Responses

(2010) C. D. Lawson et al.   JOURNAL OF IMMUNOLOGY

Characterization of the residues of αX I-domain and ICAM-1 mediating their interactions

(2010) Jeongsuk Choi et al.   MOLECULES AND CELLS

Mammary-derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion

(2010) J Nevo et al.   ONCOGENE

Requirement of open headpiece conformation for activation of leukocyte integrin  X 2

(2010) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

(2010) Paul R. Elliott et al.   STRUCTURE

Biochemical and Structural Properties of the Integrin-Associated Cytoskeletal Protein Talin

(2009) David R. Critchley   Annual Review of Biophysics

The Ins and Outs of Leukocyte Integrin Signaling

(2009) Clare L. Abram et al.   Annual Review of Immunology

Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions

(2009) E. Manevich-Mendelson et al.   BLOOD

Structure of an integrin with an αI domain, complement receptor type 4

(2009) Can Xie et al.   EMBO JOURNAL

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

(2009) Nicholas J Anthis et al.   EMBO JOURNAL

The structure of the integrin αIIbβ3 transmembrane complex explains integrin transmembrane signalling

(2009) Tong-Lay Lau et al.   EMBO JOURNAL

β Integrin Tyrosine Phosphorylation Is a Conserved Mechanism for Regulating Talin-induced Integrin Activation

(2009) Nicholas J. Anthis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Determinants of Integrin Binding to the Talin Rod

(2009) Alexandre R. Gingras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linking integrin conformation to function

(2009) J. A. Askari et al.   JOURNAL OF CELL SCIENCE

Mechanisms that regulate adaptor binding to  -integrin cytoplasmic tails

(2009) K. R. Legate et al.   JOURNAL OF CELL SCIENCE

Anti-integrin monoclonal antibodies

(2009) A. Byron et al.   JOURNAL OF CELL SCIENCE

Outside-In Signal Transmission by Conformational Changes in Integrin Mac-1

(2009) C. T. Lefort et al.   JOURNAL OF IMMUNOLOGY

The structure and function of platelet integrins

(2009) J. S. BENNETT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3

(2009) Jieqing Zhu et al.   MOLECULAR CELL

Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module

(2009) Matteo Bolomini-Vittori et al.   NATURE IMMUNOLOGY

Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

(2009) Markus Moser et al.   NATURE MEDICINE

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis

(2008) G. Carmona et al.   BLOOD

Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow

(2008) J. J. Miner et al.   BLOOD

Shedded neuronal ICAM-5 suppresses T-cell activation

(2008) L. Tian et al.   BLOOD

The GPIIb/IIIa (integrin  IIb 3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend

(2008) B. S. Coller et al.   BLOOD

Identification of a repeated domain within mammalian α-synemin that interacts directly with talin

(2008) Ning Sun et al.   EXPERIMENTAL CELL RESEARCH

Kindlin-2 controls bidirectional signaling of integrins

(2008) E. Montanez et al.   GENES & DEVELOPMENT

The Talin Rod IBS2 α-Helix Interacts with the β3 Integrin Cytoplasmic Tail Membrane-proximal Helix by Establishing Charge Complementary Salt Bridges

(2008) Sophie Rodius et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

(2008) Ho-Sup Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3

(2008) Naohide Watanabe et al.   JOURNAL OF CELL BIOLOGY

Kindlin-2 (Mig-2): a co-activator of β3integrins

(2008) Yan-Qing Ma et al.   JOURNAL OF CELL BIOLOGY

Regulation of integrin activation through the B-cell receptor

(2008) E. Arana et al.   JOURNAL OF CELL SCIENCE

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling

(2008) Alexander Zarbock et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

(2008) Jianghai Zhu et al.   MOLECULAR CELL

Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (Review)

(2008) Kate L. Wegener et al.   MOLECULAR MEMBRANE BIOLOGY

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE