Dual CCR2/5 Antagonist Attenuates Obesity-Induced Insulin Resistance by Regulating Macrophage Recruitment and M1/M2 Status

The CCR2 Inhibitor Propagermanium Attenuates Diet-Induced Insulin Resistance, Adipose Tissue Inflammation and Non-Alcoholic Steatohepatitis

(2017) Petra Mulder et al.   PLoS One

CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue

(2017) Meiyan Dai et al.   Scientific Reports

Pharmacokinetics, Safety, and CCR2/CCR5 Antagonist Activity of Cenicriviroc in Participants With Mild or Moderate Hepatic Impairment

(2016) E Lefebvre et al.   CTS-Clinical and Translational Science

High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice

(2015) Roel A van der Heijden et al.   Aging-US

Adaptive Immunity and Antigen-Specific Activation in Obesity-Associated Insulin Resistance

(2015) Melissa Hui Yen Chng et al.   MEDIATORS OF INFLAMMATION

C-C Chemokine Receptor 2 Inhibitor Ameliorates Hepatic Steatosis by Improving ER Stress and Inflammation in a Type 2 Diabetic Mouse Model

(2015) Hong-Min Kim et al.   PLoS One

Chemokine Systems Link Obesity to Insulin Resistance

(2013) Tsuguhito Ota   Diabetes & Metabolism Journal

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

(2012) H. Kitade et al.   DIABETES

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Adaptive immunity in obesity and insulin resistance

(2012) Henrike Sell et al.   Nature Reviews Endocrinology

Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist

(2011) Changsheng Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel C-C chemokine receptor 2 antagonists in metabolic disease: a review of recent developments

(2011) Young Sun Kang et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A dual CCR2/CCR5 chemokine antagonist, BMS-813160?

(2011) Peter Norman   EXPERT OPINION ON THERAPEUTIC PATENTS

Defining macrophage phenotype and function in adipose tissue

(2011) Elise Dalmas et al.   TRENDS IN IMMUNOLOGY

Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype

(2009) Koji Ohashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth

(2009) Junghyo Jo et al.   PLoS Computational Biology

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

(2008) I. Murano et al.   JOURNAL OF LIPID RESEARCH

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE