Cell-Free DNA: Hope and Potential Application in Cancer

Circulating cell-free DNA in breast cancer: size profiling, levels, and methylation patterns lead to prognostic and predictive classifiers

(2019) Maria Panagopoulou et al.   ONCOGENE

Updated developments on molecular imaging and therapeutic strategies directed against necrosis

(2019) Dongjian Zhang et al.   Acta Pharmaceutica Sinica B

Non-invasive prenatal sequencing for multiple Mendelian monogenic disorders using circulating cell-free fetal DNA

(2019) Jinglan Zhang et al.   NATURE MEDICINE

Using plasma cell free DNA to monitor the chemo‐radiotherapy course of cervical cancer

(2019) Jichao Tian et al.   INTERNATIONAL JOURNAL OF CANCER

Total circulating cell-free DNA as a prognostic biomarker in metastatic colorectal cancer before first-line oxaliplatin-based chemotherapy

(2019) J Hamfjord et al.   ANNALS OF ONCOLOGY

Detection of Colorectal Cancer in Circulating Cell-Free DNA by Methylated CpG Tandem Amplification and Sequencing

(2019) Jingyi Li et al.   CLINICAL CHEMISTRY

Circulating Tumor DNA Sequencing Analysis of Gastroesophageal Adenocarcinoma

(2019) Steven B. Maron et al.   CLINICAL CANCER RESEARCH

Circulating DNA as prognostic biomarker in patients with advanced hepatocellular carcinoma: a translational exploratory study from the SORAMIC trial

(2019) Marianna Alunni-Fabbroni et al.   Journal of Translational Medicine

Targeted sequencing of plasma cell-free DNA to predict response to PD1 inhibitors in advanced non-small cell lung cancer

(2019) Nicolas Guibert et al.   LUNG CANCER

Correlation between early dynamics in circulating tumour DNA and outcome from FOLFIRI treatment in metastatic colorectal cancer

(2019) Iben Lyskjær et al.   Scientific Reports

Long-noncoding RNAs (lncRNAs) in drug metabolism and disposition, implications in cancer chemo-resistance

(2019) Yue Wang et al.   Acta Pharmaceutica Sinica B

Circulating free DNA integrity and concentration as independent prognostic markers in metastatic breast cancer

(2018) Jie Cheng et al.   BREAST CANCER RESEARCH AND TREATMENT

Plasma total cell-free DNA (cfDNA) is a surrogate biomarker for tumour burden and a prognostic biomarker for survival in metastatic melanoma patients

(2018) S. Valpione et al.   EUROPEAN JOURNAL OF CANCER

Circulating cell-free DNA of methylated insulin-like growth factor-binding protein 7 predicts a poor prognosis in hepatitis B virus-associated hepatocellular carcinoma after hepatectomy

(2018) Feng Li et al.   FREE RADICAL RESEARCH

Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse

(2018) Karinna Almodovar et al.   Journal of Thoracic Oncology

Epigenetic markers in circulating cell-free DNA as prognostic markers for survival of castration-resistant prostate cancer patients

(2018) Rianne J. Hendriks et al.   PROSTATE

Beta Cell Death by Cell-free DNA and Outcome After Clinical Islet Transplantation

(2018) Boris L. Gala-Lopez et al.   TRANSPLANTATION

Optimal non-invasive diagnosis of fetal achondroplasia combining ultrasonography and circulating cell-free fetal DNA analysis

(2018) Alexandre J. Vivanti et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Plasma Cell-Free DNA as a Predictive Marker after Radiotherapy for Hepatocellular Carcinoma

(2018) Sangjoon Park et al.   YONSEI MEDICAL JOURNAL

Plasma ALU-247, ALU-115, and cfDNA Integrity as Diagnostic and Prognostic Biomarkers for Breast Cancer

(2018) Neveen A. Hussein et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

High levels of circulating cell-free DNA are a biomarker of active SLE

(2018) Yalan Xu et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Prognostic value of circulating cell-free DNA in patients with pancreatic cancer: A systemic review and meta-analysis

(2018) Linyan Chen et al.   GENE

Effect of Cell-Free DNA Screening vs Direct Invasive Diagnosis on Miscarriage Rates in Women With Pregnancies at High Risk of Trisomy 21

(2018) Valérie Malan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Characteristics, properties, and potential applications of circulating cell-free dna in clinical diagnostics: a focus on transplantation

(2018) Karen Sherwood et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Sequencing of Circulating Cell-free DNA during Pregnancy

(2018) Diana W. Bianchi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Somatic alterations in circulating cell-free DNA of oesophageal carcinoma patients during primary staging are indicative for post-surgical tumour recurrence

(2018) Helen Pasternack et al.   Scientific Reports

Detection of the MYD88 p.L265P Mutation in the CSF of a Patient With Secondary Central Nervous System Lymphoma

(2018) Soheil Zorofchian et al.   Frontiers in Oncology

The amount of activating EGFR mutations in circulating cell-free DNA is a marker to monitor osimertinib response

(2018) Marzia Del Re et al.   BRITISH JOURNAL OF CANCER

MYD88 p.(L265P) detection on cell-free DNA in liquid biopsies of patients with primary central nervous system lymphoma

(2018) Laura S. Hiemcke-Jiwa et al.   BRITISH JOURNAL OF HAEMATOLOGY

Increased Plasma Circulating Cell-Free DNA Could Be a Potential Marker for Oral Cancer

(2018) Li-Han Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer

(2017) Ludovic Barault et al.   GUT

Integrity and Quantity of Total Cell-Free DNA in the Diagnosis of Thyroid Cancer: Correlation with Cytological Classification

(2017) Francesca Salvianti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LINE-1 Hypermethylation in Serum Cell-Free DNA of Relapsing Remitting Multiple Sclerosis Patients

(2017) Marina Dunaeva et al.   MOLECULAR NEUROBIOLOGY

Estrogen receptor mutations and splice variants determined in liquid biopsies from metastatic breast cancer patients

(2017) Nick Beije et al.   Molecular Oncology

Integrating liquid biopsies into the management of cancer

(2017) Giulia Siravegna et al.   Nature Reviews Clinical Oncology

Analysis of Plasma Epstein–Barr Virus DNA to Screen for Nasopharyngeal Cancer

(2017) K.C. Allen Chan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct detection of early-stage cancers using circulating tumor DNA

(2017) Jillian Phallen et al.   Science Translational Medicine

Circulating cell-free DNA in plasma of colorectal cancer patients - A potential biomarker for tumor burden

(2017) Jagdeep Singh Bhangu et al.   SURGICAL ONCOLOGY-OXFORD

The Emerging Role of “Liquid Biopsies,” Circulating Tumor Cells, and Circulating Cell-Free Tumor DNA in Lung Cancer Diagnosis and Identification of Resistance Mutations

(2017) Angela Esposito et al.   Current Oncology Reports

Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition

(2017) Jane Goodall et al.   Cancer Discovery

Circulating cell-free DNA mutation patterns in early and late stage colon and pancreatic cancer

(2017) Eveline E. Vietsch et al.   Cancer Genetics

Non-invasive detection of somatic mutations using next-generation sequencing in primary central nervous system lymphoma

(2017) Maxime Fontanilles et al.   Oncotarget

Circulating Tumor DNA Mutation Profiling by Targeted Next Generation Sequencing Provides Guidance for Personalized Treatments in Multiple Cancer Types

(2017) Yongqian Shu et al.   Scientific Reports

A Prospective Evaluation of Circulating Tumor Cells and Cell-Free DNA in EGFR-Mutant Non-Small Cell Lung Cancer Patients Treated with Erlotinib on a Phase II Trial

(2016) M. Yanagita et al.   CLINICAL CANCER RESEARCH

Methylation status of the APC and RASSF1A promoter in cell-free circulating DNA and its prognostic role in patients with colorectal cancer

(2016) DIMITRIOS MATTHAIOS et al.   Oncology Letters

Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant

(2016) Jill M. Spoerke et al.   Nature Communications

Copy number variations in urine cell free DNA as biomarkers in advanced prostate cancer

(2016) Yun Xia et al.   Oncotarget

Circulating cell-free DNA as a prognostic and predictive biomarker in non-small cell lung cancer

(2016) Bo Ai et al.   Oncotarget

Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study

(2016) Christine A. Parkinson et al.   PLOS MEDICINE

Prevalence of ESR1 Mutations in Cell-Free DNA and Outcomes in Metastatic Breast Cancer

(2016) Sarat Chandarlapaty et al.   JAMA Oncology

Cell-Free DNA: An Upcoming Biomarker in Transplantation

(2015) E. M. Gielis et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Quantitative Detection of Circulating Nucleophosmin Mutations DNA in the Plasma of Patients with Acute Myeloid Leukemia

(2015) Jing Quan et al.   International Journal of Medical Sciences

Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments

(2015) Kun Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas

(2015) Yuxuan Wang et al.   Science Translational Medicine

Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer

(2015) Gaia Schiavon et al.   Science Translational Medicine

Noninvasive fetal genomic, methylomic, and transcriptomic analyses using maternal plasma and clinical implications

(2015) Ada I.C. Wong et al.   TRENDS IN MOLECULAR MEDICINE

Abstract 5606: Detection of circulating tumor DNA in early and late stage human malignancies

(2015) Chetan Bettegowda et al.   CANCER RESEARCH

Circulating Free DNA as Biomarker and Source for Mutation Detection in Metastatic Colorectal Cancer

(2015) Karen Lise Garm Spindler et al.   PLoS One

Postoperative serum methylation levels ofTAC1andSEPT9are independent predictors of recurrence and survival of patients with colorectal cancer

(2014) CheeKian Tham et al.   CANCER

Elevated Plasma cfDNA May be Associated with Active Lupus Nephritis and Partially Attributed to Abnormal Regulation of Neutrophil Extracellular Traps (NETs) in Patients with Systemic Lupus Erythematosus

(2014) Sigong Zhang et al.   INTERNAL MEDICINE

Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA

(2014) Alain R Thierry et al.   NATURE MEDICINE

Blood-Based Analyses of Cancer: Circulating Tumor Cells and Circulating Tumor DNA

(2014) D. A. Haber et al.   Cancer Discovery

Circulating Cell-Free DNA in Plasma of Locally Advanced Rectal Cancer Patients Undergoing Preoperative Chemoradiation: A Potential Diagnostic Tool for Therapy Monitoring

(2013) Matthias Zitt et al.   DISEASE MARKERS

The role of plasma cell-free DNA detection in predicting preoperative chemoradiotherapy response in rectal cancer patients

(2013) W. SUN et al.   ONCOLOGY REPORTS

NovelCDH1germline mutations identified in Chinese gastric cancer patients

(2013) Qin-Hua Chen   WORLD JOURNAL OF GASTROENTEROLOGY

Cancer therapy monitoring in xenografts by quantitative analysis of circulating tumor DNA

(2012) Tobias M. Gorges et al.   BIOMARKERS

Pleural fluid cell-free DNA integrity index to identify cytologically negative malignant pleural effusions including mesotheliomas

(2012) Krishna B Sriram et al.   BMC CANCER

Frequency of CDH1 germline mutations in gastric carcinoma coming from high- and low-risk areas: metanalysis and systematic review of the literature

(2012) Giovanni Corso et al.   BMC CANCER

Prognostic role of methylated free circulating DNA in colorectal cancer

(2012) Alexander B. Philipp et al.   INTERNATIONAL JOURNAL OF CANCER

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

(2012) Zhi Jiang Zang et al.   NATURE GENETICS

High-Throughput Mutation Profiling Identifies Frequent Somatic Mutations in Advanced Gastric Adenocarcinoma

(2012) Jeeyun Lee et al.   PLoS One

Is serum level of methylated RASSF1A valuable in diagnosing hepatocellular carcinoma in patients with chronic viral hepatitis C?

(2012) Nadia A. Mohamed et al.   Arab Journal of Gastroenterology

Circulating Cell-Free DNA: A Promising Marker of Pathologic Tumor Response in Rectal Cancer Patients Receiving Preoperative Chemoradiotherapy

(2011) Marco Agostini et al.   ANNALS OF SURGICAL ONCOLOGY

Epidermal growth factor receptor mutation in gastric cancer

(2011) Zhimin Liu et al.   PATHOLOGY

Quantitation of Plasma Circulating DNA Using Quantitative PCR for the Detection of Hepatocellular Carcinoma

(2011) Zhaohui Huang et al.   PATHOLOGY & ONCOLOGY RESEARCH

Oncogenic mutations in gastric cancer with microsatellite instability

(2010) Giovanni Corso et al.   EUROPEAN JOURNAL OF CANCER

Frequent Gastrointestinal Polyps and Colorectal Adenocarcinomas in a Prospective Series of PTEN Mutation Carriers

(2010) Brandie Heald et al.   GASTROENTEROLOGY

Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway

(2010) Tang   ONCOLOGY REPORTS

Cell-free circulating DNA in Hodgkin's and non-Hodgkin's lymphomas

(2009) S. Hohaus et al.   ANNALS OF ONCOLOGY

Detection and Monitoring of Cell-Free DNA in Blood of Patients with Colorectal Cancer

(2009) Heidi Schwarzenbach et al.   Annals of the New York Academy of Sciences

TP53 mutations in circulating free DNA from Egyptian patients with non-Hodgkin’s lymphoma

(2008) Gihan Hosny et al.   CANCER LETTERS

Quantitative Analysis of Circulating Methylated DNA as a Biomarker for Hepatocellular Carcinoma

(2008) K. C. A. Chan et al.   CLINICAL CHEMISTRY

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE