Emodin Interferes With AKT1-Mediated DNA Damage and Decreases Resistance of Breast Cancer Cells to Doxorubicin

Targeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast Cancer

(2020) Jeremy Johnson et al.   Cells

Emodin succinyl ester inhibits malignant proliferation and migration of hepatocellular carcinoma by suppressing the interaction of AR and EZH2

(2020) Hanif Khan et al.   BIOMEDICINE & PHARMACOTHERAPY

Emodin Reverses Gemcitabine Resistance of Pancreatic Cancer Cell Lines Through Inhibition of IKKβ/NF-κB Signaling Pathway

(2020) Hongfei Tong et al.   OncoTargets and Therapy

Doxorubicin liposomes cell penetration enhancement and its potential drawbacks for the tumor targeting efficiency

(2020) Hen Popilski et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Combination of cancer-specific prodrug nanoparticle with Bcl-2 inhibitor to overcome acquired drug resistance

(2020) Jinseong Kim et al.   JOURNAL OF CONTROLLED RELEASE

Emodin induces apoptosis and autophagy of fibroblasts obtained from patient with ankylosing spondylitis

(2019) Cong Ma et al.   Drug Design Development and Therapy

Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis

(2019) Zibo Li et al.   Journal of Translational Medicine

Chemical Reactivity of Aloe-Emodin and Its Hydroxylation Metabolites to Thiols

(2019) Xu Wang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Anticancer Effects of Emodin on HepG2 Cell: Evidence from Bioinformatic Analysis

(2019) Rui-sheng Zhou et al.   Biomed Research International

Absence of estrogen receptor is associated with worse oncologic outcome in patients who were received neoadjuvant chemotherapy for breast cancer

(2019) Young Ryul Park et al.   Asian Journal of Surgery

Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype

(2019) Corena V. Grant et al.   BREAST CANCER RESEARCH AND TREATMENT

Emodin, as a mitochondrial uncoupler, induces strong decreases in adenosine triphosphate (ATP) levels and proliferation of B16F10 cells, owing to their poor glycolytic reserve

(2019) Yuma Sugiyama et al.   GENES TO CELLS

Emodin protects against lipopolysaccharide-induced inflammatory injury in HaCaT cells through upregulation of miR-21

(2019) Yanping Song et al.   Artificial Cells Nanomedicine and Biotechnology

Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment

(2019) Fabiola Lilí Sarmiento-Salinas et al.   Frontiers in Oncology

Androgen Receptor Expression and Association With Distant Disease-Free Survival in Triple Negative Breast Cancer: Analysis of 263 Patients Treated With Standard Therapy for Stage I-III Disease

(2019) Maria Vittoria Dieci et al.   Frontiers in Oncology

Aryl hydrocarbon receptor counteracts pharmacological efficacy of doxorubicin via enhanced AKR1C3 expression in triple negative breast cancer cells

(2019) Naoya Yamashita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HPA aptamer functionalized paclitaxel-loaded PLGA nanoparticles for enhanced anticancer therapy through targeted effects and microenvironment modulation

(2019) Tao Duan et al.   BIOMEDICINE & PHARMACOTHERAPY

Emodin sensitizes human pancreatic cancer cells to EGFR inhibitor through suppressing Stat3 signaling pathway

(2019) Zhaohong Wang et al.   Cancer Management and Research

Emodin Inhibits EBV Reactivation and Represses NPC Tumorigenesis

(2019) Chung-Chun Wu et al.   Cancers

APC loss affects DNA damage repair causing doxorubicin resistance in breast cancer cells

(2019) Casey D. Stefanski et al.   NEOPLASIA

Triptolide sensitizes breast cancer cells to Doxorubicin through the DNA damage response inhibition

(2018) Yu Deng et al.   MOLECULAR CARCINOGENESIS

Emodin, Physcion, and Crude Extract of Rhamnus sphaerosperma var. pubescens Induce Mixed Cell Death, Increase in Oxidative Stress, DNA Damage, and Inhibition of AKT in Cervical and Oral Squamous Carcinoma Cell Lines

(2018) Thais Fernanda Moreira et al.   Oxidative Medicine and Cellular Longevity

Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma

(2018) Ilaria Buondonno et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Paradoxical Effects of Emodin on ANIT-Induced Intrahepatic Cholestasis and Herb-Induced Hepatotoxicity in Mice

(2018) Xue Wang et al.   TOXICOLOGICAL SCIENCES

p53/microRNA-374b/AKT1 regulates colorectal cancer cell apoptosis in response to DNA damage

(2017) Hangjun Gong et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Emodin Inhibition of Influenza A Virus Replication and Influenza Viral Pneumonia via the Nrf2, TLR4, p38/JNK and NF-kappaB Pathways

(2017) Jian-Ping Dai et al.   MOLECULES

Chitosan-Dextran sulfate coated doxorubicin loaded PLGA-PVA-nanoparticles caused apoptosis in doxorubicin resistance breast cancer cells through induction of DNA damage

(2017) Sumit Siddharth et al.   Scientific Reports

UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy

(2016) L Hu et al.   ONCOGENE

Inflammatory stress potentiates emodin-induced liver injury in rats

(2015) Can Tu et al.   Frontiers in Pharmacology

Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation

(2012) Robert A. Forrest et al.   BIOCHEMICAL PHARMACOLOGY