Triptolide sensitizes breast cancer cells to Doxorubicin through the DNA damage response inhibition

TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency

(2017) Kristine Lillebø Holm et al.   PLoS One

Calcitonin gene-related peptide protects type II alveolar epithelial cells from hyperoxia-induced DNA damage and cell death

(2017) Hongmin Fu et al.   Experimental and Therapeutic Medicine

UVB irradiation-enhanced zinc oxide nanoparticles-induced DNA damage and cell death in mouse skin

(2016) Anu Pal et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption

(2016) Haijun Zhao et al.   Oncotarget

Triptolide has anticancer and chemosensitization effects by down-regulating Akt activation through the MDM2/REST pathway in human breast cancer

(2016) Jing Xiong et al.   Oncotarget

Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function

(2015) Felix Y. Feng et al.   MOLECULAR CELL

Contributions of DNA repair, cell cycle checkpoints and cell death to suppressing the DNA damage-induced tumorigenic behavior of Drosophila epithelial cells

(2014) A Dekanty et al.   ONCOGENE

DNA damage dependent activation of checkpoint kinase-1 and mitogen-activated protein kinase-p38 are required in malabaricone C-induced mitochondrial cell death

(2013) Mrityunjay Tyagi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Inhibiting the DNA damage response as a therapeutic manoeuvre in cancer

(2013) N J Curtin   BRITISH JOURNAL OF PHARMACOLOGY

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond

(2013) David Davidson et al.   Frontiers in Pharmacology

Janus-Faced PIDD: A Sensor for DNA Damage-Induced Cell Death or Survival?

(2012) Francis McCoy et al.   MOLECULAR CELL

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

Various modes of cell death induced by DNA damage

(2012) O Surova et al.   ONCOGENE

Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21

(2012) Juanjuan Liu et al.   PHYTOMEDICINE

BRCA1 as a Therapeutic Target in Sporadic Epithelial Ovarian Cancer

(2010) Katherine V. Clark-Knowles et al.   Journal of Oncology

Triptolide Inhibits Bcr-Abl Transcription and Induces Apoptosis in STI571-resistant Chronic Myelogenous Leukemia Cells Harboring T315I Mutation

(2009) X. Shi et al.   CLINICAL CANCER RESEARCH

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5

(2008) B. Z. Carter et al.   BLOOD

Gene expression profiles of necrosis and apoptosis induced by 5-fluoro-2′-deoxyuridine

(2008) Akira Sato et al.   GENOMICS