Anticancer Properties of the Antipsychotic Drug Chlorpromazine and Its Synergism With Temozolomide in Restraining Human Glioblastoma Proliferation In Vitro

Repurposing chlorpromazine in the treatment of glioblastoma multiforme: analysis of literature and forthcoming steps

(2020) Claudia Abbruzzese et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mir-370-3p Impairs Glioblastoma Stem-Like Cell Malignancy Regulating a Complex Interplay between HMGA2/HIF1A and the Oncogenic Long Non-Coding RNA (lncRNA) NEAT1

(2020) Valentina Lulli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting the ABC transporter ABCB5 sensitizes glioblastoma to temozolomide-induced apoptosis through a cell-cycle checkpoint regulation mechanism

(2020) Catherine A. A. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy

(2020) Charles P. Couturier et al.   Nature Communications

Activation of dopamine receptor 2 (DRD2) prompts transcriptomic and metabolic plasticity in glioblastoma

(2019) Seamus P. Caragher et al.   JOURNAL OF NEUROSCIENCE

Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis

(2019) Verena Körber et al.   CANCER CELL

The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells

(2019) Chang-En Yang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells

(2019) Silvia Matteoni et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer

(2019) Ryan C. Gimple et al.   GENES & DEVELOPMENT

Electrical and synaptic integration of glioma into neural circuits

(2019) Humsa S. Venkatesh et al.   NATURE

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

Classics in Chemical Neuroscience: Chlorpromazine

(2018) Debra Boyd-Kimball et al.   ACS Chemical Neuroscience

Repurposing psychiatric drugs as anti-cancer agents

(2018) Jing Huang et al.   CANCER LETTERS

Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis

(2018) Mariachiara Buccarelli et al.   Cell Death & Disease

ALDH as a Stem Cell marker in solid tumors

(2018) E Mariel Toledo-Guzman et al.   Current Stem Cell Research & Therapy

ALDH1A3 induces mesenchymal differentiation and serves as a predictor for survival in glioblastoma

(2018) Guanzhang Li et al.   Cell Death & Disease

Drug repurposing for the treatment of glioblastoma multiforme

(2017) Claudia Abbruzzese et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

(2017) Xiaoyang Lan et al.   NATURE

The clinical value of patient-derived glioblastoma tumorspheres in predicting treatment response

(2017) Quintino Giorgio D’Alessandris et al.   NEURO-ONCOLOGY

The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme

(2017) Claudia Abbruzzese et al.   Oncotarget

Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit

(2017) Claudia R. Oliva et al.   Oncotarget

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Chlorpromazine inhibits mitochondrial apoptotic pathway via increasing expression of tissue factor

(2016) Jing Wu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer

(2016) Åsa Fransson et al.   Journal of Ovarian Research

Long-term survival in a patient with glioblastoma on antipsychotic therapy for schizophrenia: a case report and literature review

(2016) Shahdabul Faraz et al.   Therapeutic Advances in Medical Oncology

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity

(2015) Mona Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data

(2015) H-W Cheng et al.   Cell Death & Disease

The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells

(2013) Soon Young Shin et al.   CARCINOGENESIS

Brain tumor stem cells: Molecular characteristics and their impact on therapy

(2013) David L. Schonberg et al.   MOLECULAR ASPECTS OF MEDICINE

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

Chlorpromazine Protects Against Apoptosis Induced by Exogenous Stimuli in the Developing Rat Brain

(2011) Jing Wu et al.   PLoS One

Potential therapeutic implications of cancer stem cells in glioblastoma

(2010) Lin Cheng et al.   BIOCHEMICAL PHARMACOLOGY

Chlorpromazine activates p21Waf1/Cip1gene transcription via early growth response-1 (Egr-1) in C6 glioma cells

(2010) Soon Young Shin et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Cytotoxic effects of antipsychotic drugs implicate cholesterol homeostasis as a novel chemotherapeutic target

(2009) Erik D. Wiklund et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer Stem Cell Analysis and Clinical Outcome in Patients with Glioblastoma Multiforme

(2008) R. Pallini et al.   CLINICAL CANCER RESEARCH