Article
Oncology
Alicia Eckhardt, Richard Drexler, Melanie Schoof, Nina Struve, David Capper, Claudius Jelgersma, Julia Onken, Patrick N. Harter, Katharina J. Weber, Iris Dive, Kai Rothkamm, Konstantin Hoffer, Lukas Klumpp, Katrin Ganser, Cordula Petersen, Franz Ricklefs, Malte Kriegs, Ulrich Schueller
Summary: Mean global DNA methylation is independently associated with outcome in glioblastoma. Higher DNA methylation is associated with better radiotherapy response and less aggressive phenotype.
Article
Multidisciplinary Sciences
Lingyu Zhang, Yu Li, Yibei Dai, Danhua Wang, Xuchu Wang, Ying Cao, Weiwei Liu, Zhihua Tao
Summary: Metabolic pattern reconstruction in tumor progression involves abnormal increase in anaerobic glycolysis, leading to rapid cell proliferation and tumor growth. A study identifying 8 glycolysis-related genes correlated with overall survival and recurrence-free survival in LIHC demonstrated high AUC value. A well-fitted nomogram based on gene expression profiles and clinical characteristics showed good discrimination in internal and external cohorts.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Edoardo L. M. Gelardi, Diego Caprioglio, Giorgia Colombo, Erika Del Grosso, Daniele Mazzoletti, Daiana Mattoteia, Stefano Salamone, Davide M. Ferraris, Eleonora Aronica, Giulia Nato, Annalisa Buffo, Menico Rizzi, Lorenzo Magrassi, Alberto Minassi, Silvia Garavaglia
Summary: Curcumin-based fluorescent probes are developed to selectively bind to ALDH1A3 and identify glioblastoma cells. These probes show high selectivity and specificity in vitro and in vivo, making them potential useful tools for glioblastoma cell detection.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jinsook Son, Wen Du, Mark Esposito, Kaavian Shariati, Hongxu Ding, Yibin Kang, Domenico Accili
Summary: This study provides evidence of re-differentiation of dedifferentiated beta-cells in type 2 diabetes and identifies ALDH1A3 as a key player in this process. The inhibition of ALDH1A3 is proposed as a treatment method for beta-cell dysfunction in diabetes.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Chun Cheng, Jun Yang, Si-Wei Li, Guofu Huang, Chenxi Li, Wei-Ping Min, Yi Sang
Summary: Histone deacetylases (HDACs) are involved in tumor progression, with HDAC4 playing a crucial role in promoting cell proliferation, migration, and invasion in nasopharyngeal carcinoma (NPC). High expression of HDAC4 in NPC tissues is associated with poor overall survival and progression-free survival. Inhibition of HDAC4 may present a potential therapeutic strategy for NPC patients.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Yajing Zhang, Shangyi Luo, Ying Jia, Xue Zhang
Summary: Telomere maintenance mechanisms (TMMs) show consistent dysregulation across various cancers, and the TMScore based on TMM dysregulation is positively associated with tumor adverse features. Two prognostic patterns based on TMScore were identified for breast and lung cancer patients (poorer outcomes) and colon and stomach cancer patients (better outcomes). The prognostic value of TMScore remains significant regardless of whether patients received adjuvant therapy, and it can predict the effectiveness of adjuvant therapy.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Genetics & Heredity
Zhong-Fang Shi, Guan-Zhang Li, You Zhai, Chang-Qing Pan, Di Wang, Ming-Chen Yu, Chi Liu, Wei Zhang, Xiao-Guang Yu
Summary: This study found that EGFRvIII activated the NF-κB pathway and regulated the expression of ALDH1A3, promoting the proneural-mesenchymal transition of GBM and reducing its sensitivity to TMZ. This provides an experimental basis for the selection of clinical drugs for GBM patients with EGFRvIII (+).
Article
Multidisciplinary Sciences
Yong Liu, Yuelin Liu, Yong Gao, Lei Wang, Hengliang Shi, Chengmin Xuan
Summary: This study identified the regulatory pathway of H19 and hsa-miR-338-3P in regulating NRP1 expression in GBM, which plays an important role in the disease.
Article
Oncology
Shraddha Subramanian, Alexes C. Daquinag, Solmaz AghaAmiri, Sukhen C. Ghosh, Ali Azhdarinia, Mikhail G. Kolonin
Summary: Metastasis is a major cause of cancer-related deaths, and current chemoresistance makes metastatic cancers difficult to treat. This study identifies peptides that specifically target metastatic cells, demonstrating their potential as noninvasive imaging probes and vehicles for cytotoxic therapy delivery in preclinical cancer models.
Article
Biochemistry & Molecular Biology
Morio Yamazaki, Kotaro Sugimoto, Yo Mabuchi, Rina Yamashita, Naoki Ichikawa-Tomikawa, Tetsuharu Kaneko, Chihiro Akazawa, Hiroshi Hasegawa, Tetsuya Imura, Hideki Chiba
Summary: Junctional adhesion molecules (JAMs) have been found to exhibit a novel mode of interaction and biological activity in adipose-derived stromal/stem cells, with JAM-C playing a significant role in cell adhesion and proliferation. The cleaved form of JAM-C, sJAM-C, can stimulate adhesion and maintenance of ADSCs in conjunction with JAM-B. These findings suggest a unique functional role of sJAM-C in ADSCs, contributing to not only cell-cell adhesion, but also cell-matrix adhesion.
Article
Gastroenterology & Hepatology
Wen-Dan Chen, Xin Zhang, Meng-Jiao Zhang, Ya-Ping Zhang, Zi-Qi Shang, Yi-Wei Xin, Yi Zhang
Summary: The abundance of salivary Fusobacterium nucleatum (Fn) was found to be significantly increased in patients with gastric cancer (GC), and the level of salivary Fn could be used as a promising biomarker for diagnosing GC. Moreover, Fn infection could promote GC metastasis by accelerating the epithelial-mesenchymal transition (EMT) process.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Raphael Porret, Raphael P. H. Meier, Josip Mikulic, Manuel Pascual, Vincent Aubert, Thomas Harr, Dela Golshayan, Yannick D. D. Muller, Swiss Transplant Cohort Study
Summary: The study found that atopy is associated with better long-term patient and graft survival after kidney transplantation, independently of age and living donor donation. However, it does not affect the occurrence of acute rejection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jian Hou, Liqun Shang, Suiqing Huang, Yuanhan Ao, Jianping Yao, Zhongkai Wu
Summary: This study investigates the significance of postoperative serum creatinine in predicting the prognosis of cardiac surgery patients. The results show a positive correlation between postoperative serum creatinine and hospital mortality, suggesting the potential of using postcardiac surgery serum creatinine as an outcome indicator.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Daqi Li, Qian Zhang, Lu Li, Kexin Chen, Junlei Yang, Deobrat Dixit, Ryan C. Gimple, Shusheng Ci, Chenfei Lu, Lang Hu, Jiancheng Gao, Danyang Shan, Yangqing Li, Junxia Zhang, Zhumei Shi, Danling Gu, Wei Yuan, Qiulian Wu, Kailin Yang, Linjie Zhao, Zhixin Qiu, Deguang Lv, Wei Gao, Hui Yang, Fan Lin, Qianghu Wang, Jianghong Man, Chaojun Li, Weiwei Tao, Sameer Agnihotri, Xu Qian, Yu Shi, Yongping You, Nu Zhang, Jeremy N. Rich, Xiuxing Wang
Summary: The study reveals the tumor-promoting functions of B2M in glioblastoma and suggests potential therapeutic strategies for targeting tumor cells and the immunosuppressive microenvironment. B2M activation leads to the maintenance of stem-like neoplastic populations and induces an anti-inflammatory state, while promoting the polarization of macrophages towards an M2-like phenotype. Inhibition of B2M could attenuate glioblastoma stem cell survival, self-renewal, and tumor growth.
Article
Multidisciplinary Sciences
Abicumaran Uthamacumaran, Morgan Craig
Summary: This study utilized network and data science methods to investigate gene expression patterns in glioblastoma, identifying eight transcription factors and four signaling genes as coordinators of cell state transitions. The findings highlight the potential for complex systems approaches to uncover clinically relevant targets in glioblastoma.
Article
Computer Science, Information Systems
Zhenzhe Zheng, Shuo Yang, Jiapeng Xie, Fan Wu, Xiaofeng Gao, Guihai Chen
Summary: Mobile crowdsensing is gaining popularity due to its ability to collect a large amount of data with the help of individual smartphone users. Designing an incentive mechanism for compensating participants is important for attracting more participation. This paper investigates online crowdsensing and proposes a new method for selecting users based on time-dependent values, as well as a strategy-proof framework. The proposed mechanisms achieve computational efficiency, budget feasibility, strategy-proofness, and a constant competitive ratio in the context of time-discounting values.
IEEE TRANSACTIONS ON MOBILE COMPUTING
(2022)
Article
Green & Sustainable Science & Technology
Wei Jiang, Fan Wu, Ziyue Mei, Rui Shi, Danmei Xie
Summary: Low-grade flow energy can be effectively utilized by flapping foil at low Reynolds number, with spline motion profile providing better energy extraction performance.
JOURNAL OF RENEWABLE AND SUSTAINABLE ENERGY
(2022)
Article
Cell Biology
Yingdan Wang, Meiqin Liu, Yaping Shen, Yunping Ma, Xiang Li, Yuanyuan Zhang, Mei Liu, Xing-Lou Yang, Jun Chen, Renhong Yan, Die Luan, Yanqun Wang, Ying Chen, Qimin Wang, Haofeng Lin, Yaning Li, Kaiyue Wu, Tongyu Zhu, Jincun Zhao, Hongzhou Lu, Yumei Wen, Shibo Jiang, Fan Wu, Qiang Zhou, Zheng-Li Shi, Jinghe Huang
Summary: The emergence of SARS-CoV-2 variants of concern has raised alarm due to their increased infectivity, transmissibility, and decreased sensitivity to antibodies and vaccines. This study introduces a bispecific antibody, G9, that can neutralize a wide range of variants, including the Omicron variant.
Article
Chemistry, Physical
Zhiqian Yang, Liqun Duan, Gang Chang, Wenke Zhou, Zhi Zhang, Fan Wu, Aming Xie, Ziming Xiong
Summary: In this study, a series of carbon microfiber/FeS composites were synthesized using a molten-salt-guided synthetic strategy. The microstructures, electromagnetic response behaviors, and microwave absorption properties of these composites were systematically investigated. The results showed that the prepared composites exhibited effective microwave absorption performance, and the choice of molten salt system had an influence on the properties of the composites.
Article
Oncology
Ulf D. Kahlert, Wenjie Shi, Marco Strecker, Lorenz A. Scherpinski, Thomas Wartmann, Maximilian Doelling, Aristotelis Perrakis, Borna Relja, Miriam Mengoni, Andreas Braun, Roland S. Croner
Summary: This study demonstrates that COL10A1 expression is associated with metastasis and immunogenic properties in colorectal cancer, and its transcription may mediate tumor cell interaction with the stromal microenvironment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Elham Poonaki, Ulf Dietrich Kahlert, Sven G. Meuth, Ali Gorji
Summary: Zinc finger E-box binding homeobox 1 (ZEB1) is a critical regulator of epithelial-mesenchymal transition (EMT) and plays a key role in neuroinflammation. The ZEB1-neuroinflammation axis is crucial for the pathogenesis of various CNS disorders and may serve as a diagnostic, prognostic, and therapeutic target.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Computer Science, Information Systems
Yuben Qu, Dongyu Lu, Haipeng Dai, Haisheng Tan, Shaojie Tang, Fan Wu, Chao Dong
Summary: This paper studies the problem of resilient service provisioning for edge computing, aiming to determine a service placement strategy to maximize overall utility in the presence of uncertain service failures. Two novel solutions are proposed for the general and homogeneous case, respectively, achieving constant approximation ratio within polynomial time and better approximation ratio than previous methods. Extensive simulations and field experiments validate the effectiveness of the proposed algorithms.
IEEE INTERNET OF THINGS JOURNAL
(2023)
Article
Computer Science, Information Systems
Qinya Li, Zun Li, Zhenzhe Zheng, Fan Wu, Shaojie Tang, Zhao Zhang, Guihai Chen
Summary: With the fast-growing market demand, more and more IoT data is being traded online in cloud-based data marketplaces. However, data consumers face difficulties in making purchasing decisions due to uncertain data quality and inflexible pricing interface. To address these issues, potential solutions include launching data demonstrations and releasing free sampling data to reduce uncertainty about data quality, and implementing flexible pricing based on the volume of data used. The economic benefits of these mechanisms are not yet clear. In this paper, we design optimal data selling mechanisms for IoT data exchange and derive two main findings based on theoretical analysis and evaluation on a real-world Taxi GPS dataset.
IEEE TRANSACTIONS ON MOBILE COMPUTING
(2023)
Article
Virology
Tingting Sun, Yingdan Wang, Peng Zou, Qimin Wang, Jiangyan Liu, Wanli Liu, Jinghe Huang, Fan Wu
Summary: The study constructed three different variants of M2e-specific monoclonal antibodies and found that IgG2a variant provided better protection against influenza virus. Additionally, the administration route and timing of administration were critical factors in determining the protective efficacy.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Qiushi Yin, Qiuxi Yang, Wenjie Shi, Ulf D. Kahlert, Zhongyi Li, Shibu Lin, Qifeng Song, Weiqiang Fan, Li Wang, Yi Zhu, Xiaolong Huang
Summary: This study used a two-sample Mendelian randomization analysis to investigate the genetic association between inflammatory traits and liver cancer. The results showed no significant genetic association between extrahepatic immune-mediated diseases, circulating inflammatory biomarkers, cytokines, and liver cancer. These findings have important implications for liver cancer research.
Article
Engineering, Civil
Muhammad Asad Saleem, Xiong Li, Muhammad Faizan Ayub, Salman Shamshad, Fan Wu, Haider Abbas
Summary: The popularity of vehicles has led to the development of smart cities, making vehicular ad-hoc network (VANET) a widely used communication method for obtaining information about road conditions, speed, vehicle location, and traffic congestion. However, the security of private data in VANET is a critical task due to various security threats. In this article, a lightweight and secure privacy-preserving key agreement protocol for VANETs is proposed, which utilizes hashing technique for efficient and secure data transmission.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Chemistry, Physical
Junru Yao, Jintang Zhou, Feng Yang, Guiyu Peng, Yijie Liu, Zhengjun Yao, Fan Wu, Haibo Zeng
Summary: The development of multifunctional materials and the integration of various functions are crucial for integrated and miniaturized equipment. In this study, asymmetric MXene/aramid nanofibers/polyimides (AMAP) aerogels were developed through an integrated molding process. The clever asymmetry of these aerogels allows for enhanced performances, such as low reflection electromagnetic interference (EMI) shielding, high-efficiency infrared radiation stealth, and excellent thermal management performances. These multifunctional AMAP aerogels have potential applications in electromagnetic pollution protection, insulation, and military equipment protection against infrared detection and EMI.
Article
Multidisciplinary Sciences
Anna Schaufler, Ahmed Y. Sanin, I. Erol Sandalcioglu, Karl Hartmann, Roland S. Croner, Aristotelis Perrakis, Thomas Wartmann, Axel Boese, Ulf D. Kahlert, Igor Fischer
Summary: The current treatment for glioblastoma has limitations and can often result in recurrence. Standard MRI imaging surveillance may not accurately detect histological changes, leading to incorrect conclusions about treatment and interventions. To address these challenges, an implantable system using optical sensing of cancer cells is proposed to continuously monitor glioblastoma recurrence. The feasibility of the sensing principle has been demonstrated through experimental trials, and the system design has been further developed to include wireless energy transfer and power management circuitry.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Analytical
Lennard M. Wurm, Bjoern Fischer, Volker Neuschmelting, David Reinecke, Igor Fischer, Roland S. Croner, Roland Goldbrunner, Michael C. Hacker, Jakub Dybas, Ulf D. Kahlert
Summary: Label-free identification of tumor cells using spectroscopic assays combined with machine learning algorithms can improve the rapid implementation of clinical care. The ability to distinguish different types of tumor cells and their phenotypes is important for accurate diagnosis and treatment.
Review
Materials Science, Multidisciplinary
Jing Qiao, Lutong Li, Jiurong Liu, Na Wu, Wei Liu, Fan Wu, Zhihui Zeng
Summary: Rare earth plays a crucial role in electromagnetic wave absorption materials, and the strategies of doping rare earth elements and constructing rare earth oxide composites are important for the fabrication of high-efficiency electromagnetic wave absorption materials. This review provides a comprehensive summary of the research background, classification, features, progress, and future development of rare earth electromagnetic wave absorption materials, offering guidance for future development.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2024)
