Immunotherapy of Glioblastoma: Current Strategies and Challenges in Tumor Model Development

Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy

(2021) Matthias Gromeier et al.   Nature Communications

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis

(2020) Zhe Zhu et al.   Cell Stem Cell

Potential of Glioblastoma-Targeted Chimeric Antigen Receptor (CAR) T-Cell Therapy

(2020) Ryan D. Salinas et al.   CNS DRUGS

Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies

(2020) Ana Rita Pombo Antunes et al.   eLife

Resistance Mechanisms and Barriers to Successful Immunotherapy for Treating Glioblastoma

(2020) Jason Adhikaree et al.   Cells

The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma

(2020) Parvez Vora et al.   Cell Stem Cell

HSP70/IL-2 Treated NK Cells Effectively Cross the Blood Brain Barrier and Target Tumor Cells in a Rat Model of Induced Glioblastoma Multiforme (GBM)

(2020) Farzaneh Sharifzad et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Challenges to Successful Implementation of the Immune Checkpoint Inhibitors for Treatment of Glioblastoma

(2020) Stephanie Sanders et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A review of glioblastoma immunotherapy

(2020) Ravi Medikonda et al.   JOURNAL OF NEURO-ONCOLOGY

Mechanisms and therapeutic implications of hypermutation in gliomas

(2020) Mehdi Touat et al.   NATURE

Biomarkers for immunotherapy for treatment of glioblastoma

(2020) John P Lynes et al.   Journal for ImmunoTherapy of Cancer

Temozolomide antagonizes oncolytic immunovirotherapy in glioblastoma

(2020) Dipongkor Saha et al.   Journal for ImmunoTherapy of Cancer

PD-1 inhibitors: Do they have a future in the treatment of glioblastoma?

(2020) Mustafa Khasraw et al.   CLINICAL CANCER RESEARCH

CCR5-Mediated Signaling is Involved in Invasion of Glioblastoma Cells in Its Microenvironment

(2020) Metka Novak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immune suppression in gliomas

(2020) Matthew M. Grabowski et al.   JOURNAL OF NEURO-ONCOLOGY

Emerging immunotherapies for malignant glioma: from immunogenomics to cell therapy

(2020) Gavin P Dunn et al.   NEURO-ONCOLOGY

CD133 mRNA-Loaded Dendritic Cell Vaccination Abrogates Glioma Stem Cell Propagation in Humanized Glioblastoma Mouse Model

(2020) Angelique Sao-Mai Sy Do et al.   Molecular Therapy-Oncolytics

Glioblastoma Organoids: Pre-Clinical Applications and Challenges in the Context of Immunotherapy

(2020) Eliane Klein et al.   Frontiers in Oncology

Vectors for Glioblastoma Gene Therapy: Viral & Non-Viral Delivery Strategies

(2019) Breanne Caffery et al.   Nanomaterials

Virus-Based Immunotherapy of Glioblastoma

(2019) Miika Martikainen et al.   Cancers

Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts

(2019) A. Capasso et al.   Journal for ImmunoTherapy of Cancer

Modeling Patient-Derived Glioblastoma with Cerebral Organoids

(2019) Amanda Linkous et al.   Cell Reports

Organoids — Preclinical Models of Human Disease

(2019) Mo Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Modulation of temozolomide dose differentially affects T-cell response to immune checkpoint inhibition

(2019) Aida Karachi et al.   NEURO-ONCOLOGY

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

(2019) Timothy F. Cloughesy et al.   NATURE MEDICINE

Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma

(2019) Kurt A. Schalper et al.   NATURE MEDICINE

Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice

(2019) Saumi Mathews et al.   Molecular Neurodegeneration

Antitumor efficacy of chimeric antigen receptor T cells against EGFRvIII-expressing glioblastoma in C57BL/6 mice

(2019) Muhua Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

(2019) Oded Kopper et al.   NATURE MEDICINE

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

(2019) Anne Dirkse et al.   Nature Communications

A Characterization of Dendritic Cells and Their Role in Immunotherapy in Glioblastoma: From Preclinical Studies to Clinical Trials

(2019) Siddhartha Srivastava et al.   Cancers

CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity

(2019) Bryan D. Choi et al.   NATURE BIOTECHNOLOGY

Similarities Between Stem Cell Niches in Glioblastoma and Bone Marrow: Rays of Hope for Novel Treatment Strategies

(2019) Vashendriya V.V. Hira et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Microenvironmental Heterogeneity in Brain Malignancies

(2019) Lucas J. M. Perus et al.   Frontiers in Immunology

CAR-Engineered NK Cells for the Treatment of Glioblastoma: Turning Innate Effectors Into Precision Tools for Cancer Immunotherapy

(2019) Michael C. Burger et al.   Frontiers in Immunology

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

(2019) Fadi Jacob et al.   CELL

Probiotic-Treated Super-Charged NK Cells Efficiently Clear Poorly Differentiated Pancreatic Tumors in Hu-BLT Mice

(2019) Kawaljit Kaur et al.   Cancers

Development of Patient-Derived Gastric Cancer Organoids from Endoscopic Biopsies and Surgical Tissues

(2018) Mei Gao et al.   ANNALS OF SURGICAL ONCOLOGY

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer

(2018) Suk Hyung Lee et al.   CELL

Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy

(2018) Minan Wang et al.   FASEB JOURNAL

Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy

(2018) Yue Zhao et al.   GUT

The Immune Landscape of Cancer

(2018) Vésteinn Thorsson et al.   IMMUNITY

Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar

(2018) Vashendriya V.V. Hira et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

(2018) Linda M. Liau et al.   Journal of Translational Medicine

Genetically engineered cerebral organoids model brain tumor formation

(2018) Shan Bian et al.   NATURE METHODS

Current state of immunotherapy for glioblastoma

(2018) Michael Lim et al.   Nature Reviews Clinical Oncology

Multidimensional communication in the microenvirons of glioblastoma

(2018) Marike L. Broekman et al.   Nature Reviews Neurology

Durable complete responses in some recurrent high-grade glioma patients treated with Toca 511 + Toca FC

(2018) Timothy F Cloughesy et al.   NEURO-ONCOLOGY

Glioblastoma Model Using Human Cerebral Organoids

(2018) Junko Ogawa et al.   Cell Reports

Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs

(2018) Kawaljit Kaur et al.   OncoImmunology

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors

(2018) Pakawat Chongsathidkiet et al.   NATURE MEDICINE

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

(2018) Fanny Herisson et al.   NATURE NEUROSCIENCE

Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors

(2018) Diana Matias et al.   Frontiers in Cellular Neuroscience

Challenges in the Treatment of Glioblastoma: Multisystem Mechanisms of Therapeutic Resistance

(2018) Evan K. Noch et al.   World Neurosurgery

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

(2018) Helen H.N. Yan et al.   Cell Stem Cell

Targeting Cancer Stemness in the Clinic: From Hype to Hope

(2018) Caner Saygin et al.   Cell Stem Cell

Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy

(2018) Carmela Passaro et al.   CLINICAL CANCER RESEARCH

Establishment of peripheral blood mononuclear cell-derived humanized lung cancer mouse models for studying efficacy of PD-L1/PD-1 targeted immunotherapy

(2018) Shouheng Lin et al.   mAbs

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

(2018) Harald Lund et al.   Nature Communications

Mouse Models for Cancer Immunotherapy Research

(2018) Brian Olson et al.   Cancer Discovery

NK Cell-Based Glioblastoma Immunotherapy

(2018) Irene Golán et al.   Cancers

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma

(2017) Roger Stupp et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Overcoming therapeutic resistance in glioblastoma: the way forward

(2017) Satoru Osuka et al.   JOURNAL OF CLINICAL INVESTIGATION

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

(2017) Michael Weller et al.   LANCET ONCOLOGY

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Dissecting inherent intratumor heterogeneity in patient-derived glioblastoma culture models

(2017) Jian Teng et al.   NEURO-ONCOLOGY

Trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma

(2017) Kevin Bielamowicz et al.   NEURO-ONCOLOGY

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

(2017) Donald M. O’Rourke et al.   Science Translational Medicine

A Human Glioblastoma Organotypic Slice Culture Model for Study of Tumor Cell Migration and Patient-specific Effects of Anti-Invasive Drugs

(2017) Jonathon J. Parker et al.   Jove-Journal of Visualized Experiments

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells

(2016) Anna K. Kozlowska et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Analysis of Immune Cells from Human Mammary Ductal Epithelial Organoids Reveals Vδ2 + T Cells That Efficiently Target Breast Carcinoma Cells in the Presence of Bisphosphonate

(2016) Nicholas A. Zumwalde et al.   Cancer Prevention Research

A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

(2016) Christopher G. Hubert et al.   CANCER RESEARCH

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Complex Tissue and Disease Modeling using hiPSCs

(2016) Robert Passier et al.   Cell Stem Cell

A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma

(2016) R. Rampling et al.   CLINICAL CANCER RESEARCH

Antitumor Effect of Programmed Death-1 (PD-1) Blockade in Humanized the NOG-MHC Double Knockout Mouse

(2016) Tadashi Ashizawa et al.   CLINICAL CANCER RESEARCH

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

Patient-derived induced pluripotent stem cells in cancer research and precision oncology

(2016) Eirini P Papapetrou   NATURE MEDICINE

Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma

(2016) Lee A. Wheeler et al.   NEURO-ONCOLOGY

The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

(2016) D. F. Quail et al.   SCIENCE

Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion

(2016) Balint Otvos et al.   STEM CELLS

Anti-ovarian tumor response of donor peripheral blood mononuclear cells is due to infiltrating cytotoxic NK cells

(2016) Veethika Pandey et al.   Oncotarget

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma

(2015) Congcong Zhang et al.   JNCI-Journal of the National Cancer Institute

Tumor-Derived Cell Lines as Molecular Models of Cancer Pharmacogenomics

(2015) A. Goodspeed et al.   MOLECULAR CANCER RESEARCH

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

IDO inhibitors move center stage in immuno-oncology

(2015) Cormac Sheridan   NATURE BIOTECHNOLOGY

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Strategies to improve delivery of anticancer drugs across the blood–brain barrier to treat glioblastoma

(2015) Rajneet K. Oberoi et al.   NEURO-ONCOLOGY

Regulatory T cells are not a strong predictor of survival for patients with glioblastoma

(2015) A. A. Thomas et al.   NEURO-ONCOLOGY

Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain

(2015) Kristan E. van der Vos et al.   NEURO-ONCOLOGY

ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma

(2015) Congcong Zhang et al.   JNCI-Journal of the National Cancer Institute

Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model

(2015) D. A. Reardon et al.   Cancer Immunology Research

CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells

(2015) Jianfeng Han et al.   Scientific Reports

Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors

(2014) D. A. Wainwright et al.   CLINICAL CANCER RESEARCH

Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond

(2014) Christopher S. Garris et al.   IMMUNOLOGY

Immunocompetent murine models for the study of glioblastoma immunotherapy

(2014) Taemin Oh et al.   Journal of Translational Medicine

Transforming growth factor-beta and its implication in the malignancy of gliomas

(2014) Laurent-Olivier Roy et al.   Targeted Oncology

Emerging Therapies for Glioblastoma

(2014) Alissa A. Thomas et al.   JAMA Neurology

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

(2013) R. Romee et al.   BLOOD

Clinical significance of macrophage heterogeneity in human malignant tumors

(2013) Yoshihiro Komohara et al.   CANCER SCIENCE

Glioblastoma and Other Malignant Gliomas

(2013) Antonio Omuro   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The prognostic value of Foxp3+ tumor-infiltrating lymphocytes in patients with glioblastoma

(2013) Qi Yue et al.   JOURNAL OF NEURO-ONCOLOGY

Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments

(2013) Felicitas Merz et al.   NEURO-ONCOLOGY

Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model

(2013) T. A. Cheema et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patient-Specific Orthotopic Glioblastoma Xenograft Models Recapitulate the Histopathology and Biology of Human Glioblastomas In Situ

(2013) Kyeung Min Joo et al.   Cell Reports

The natural killer cell response and tumor debulking are associated with prolonged survival in recurrent glioblastoma patients receiving dendritic cells loaded with autologous tumor lysates

(2013) Serena Pellegatta et al.   OncoImmunology

Biology of brain metastases and novel targeted therapies: Time to translate the research

(2012) Emmanouil Fokas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

NOD/scid IL-2Rgnull mice: a preclinical model system to evaluate human dendritic cell-based vaccine strategies in vivo

(2012) Stefani Spranger et al.   Journal of Translational Medicine

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

In vivo models of primary brain tumors: pitfalls and perspectives

(2012) P. C. Huszthy et al.   NEURO-ONCOLOGY

The molecular profile of microglia under the influence of glioma

(2012) W. Li et al.   NEURO-ONCOLOGY

Xenogeneic Graft-versus-Host-Disease in NOD-scid IL-2Rγnull Mice Display a T-Effector Memory Phenotype

(2012) Niwa Ali et al.   PLoS One

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

TGF-  downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients

(2011) C. A. Crane et al.   NEURO-ONCOLOGY

CD133/prominin1 is prognostic for GBM patient's survival, but inversely correlated with cysteine cathepsins' expression in glioblastoma derived spheroids

(2011) Seyed Ardebili et al.   Radiology and Oncology

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma

(2010) John H. Sampson et al.   JOURNAL OF CLINICAL ONCOLOGY

Prognostic significance and mechanism of Treg infiltration in human brain tumors

(2010) Joannes F.M. Jacobs et al.   JOURNAL OF NEUROIMMUNOLOGY

Tumor heterogeneity: Causes and consequences

(2009) Andriy Marusyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

(2009) Mark Shackleton et al.   CELL

Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment

(2008) Morgan O'Hayre et al.   BIOCHEMICAL JOURNAL

Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients

(2008) F. Zeppernick et al.   CLINICAL CANCER RESEARCH