Upregulation of the Renin–Angiotensin System Pathways and SARS-CoV-2 Infection: The Rationale for the Administration of Zinc-Chelating Agents in COVID-19 Patients

Antibodies, epicenter of SARS-CoV-2 immunology

(2021) Simone Pecetta et al.   CELL DEATH AND DIFFERENTIATION

Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences

(2021) Sheila K. Patel et al.   EUROPEAN RESPIRATORY JOURNAL

Zinc against COVID-19? Symptom surveillance and deficiency risk groups

(2021) Marcin P. Joachimiak   PLoS Neglected Tropical Diseases

Risk Management and Treatment of Coagulation Disorders Related to COVID-19 Infection

(2021) Christian Zanza et al.   International Journal of Environmental Research and Public Health

Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection

(2021) Suma Thomas et al.   JAMA Network Open

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

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Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

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Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019

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Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors

(2020) Iziah E Sama et al.   EUROPEAN HEART JOURNAL

Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)

(2020) Anatoly Skalny et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Novel Coronavirus 2019 epidemic and kidneys

(2020) Saraladevi Naicker et al.   KIDNEY INTERNATIONAL

Welding Fumes, a Risk Factor for Lung Diseases

(2020) Maria Grazia Riccelli et al.   International Journal of Environmental Research and Public Health

Recombinant human ACE2: potential therapeutics of SARS-CoV-2 infection and its complication

(2020) Xiaocong Pang et al.   ACTA PHARMACOLOGICA SINICA

Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

(2020) Chiara Agrati et al.   CELL DEATH AND DIFFERENTIATION

COVID-19, SARS and MERS: are they closely related?

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Mortality reduction in 46 severe Covid-19 patients treated with hyperimmune plasma. A proof of concept single arm multicenter trial

(2020) Cesare Perotti et al.   HAEMATOLOGICA

Studying the Effects of ACE2 Mutations on Stability, Dynamics and Dissociation Process of SARS-CoV-2 S1/hACE2 Complexes

(2020) Hamid Hadi-Alijanvand et al.   JOURNAL OF PROTEOME RESEARCH

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

Autoimmune and inflammatory diseases following COVID-19

(2020) Caroline Galeotti et al.   Nature Reviews Rheumatology

ACE2 and COVID-19 and the resulting ARDS

(2020) Xiaoqing Zhang et al.   POSTGRADUATE MEDICAL JOURNAL

The Yin and Yang of ACE/ACE2 Pathways: The Rationale for the Use of Renin-Angiotensin System Inhibitors in COVID-19 Patients

(2020) Loris Zamai   Cells

Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease

(2020) Yan Zhao et al.   JCI Insight

Zinc and COVID-19: Basis of Current Clinical Trials

(2020) Amit Pal et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation

(2020) Lars Wallentin et al.   EUROPEAN HEART JOURNAL

Does zinc supplementation enhance the clinical efficacy of chloroquine/hydroxychloroquine to win today's battle against COVID-19?

(2020) R. Derwand et al.   MEDICAL HYPOTHESES

A dynamic COVID-19 immune signature includes associations with poor prognosis

(2020) Adam G. Laing et al.   NATURE MEDICINE

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Mechanisms of immune suppression by myeloid-derived suppressor cells: the role of interleukin-10 as a key immunoregulatory cytokine

(2020) Mahmoud Mohammad Yaseen et al.   Open Biology

Human recombinant soluble ACE2 in severe COVID-19

(2020) Alexander Zoufaly et al.   Lancet Respiratory Medicine

A Review of the Progress and Challenges of Developing a Vaccine for COVID-19

(2020) Omna Sharma et al.   Frontiers in Immunology

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

(2020) Wen Shi Lee et al.   Nature Microbiology

Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters

(2020) Shuofeng Yuan et al.   Nature Microbiology

Venous Thrombo-Embolism in Hospitalized SARS-CoV-2 Patients Treated with Three Different Anticoagulation Protocols: Prospective Observational Study

(2020) Yaroslava Longhitano et al.   Biology-Basel

A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia

(2020) Ventura A. Simonovich et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Potential Role of Interleukin 10 in COVID-19 Pathogenesis

(2020) Ligong Lu et al.   TRENDS IN IMMUNOLOGY

Modeling the Molecular Impact of SARS-CoV-2 Infection on the Renin-Angiotensin System

(2020) Fabrizio Pucci et al.   Viruses-Basel

Neutralizing antibodies for the treatment of COVID-19

(2020) Shibo Jiang et al.   Nature Biomedical Engineering

The pro-inflammatory stimulus of zinc- and copper-containing welding fumes in whole blood assay via protein tyrosine phosphatase 1B inhibition

(2019) Johannes Bleidorn et al.   Scientific Reports

Serum cytokine patterns in immunoglobulin m monoclonal gammopathy‐associated polyneuropathy

(2019) Abraham C. J. Stork et al.   MUSCLE & NERVE

Defective Zn2+ homeostasis in mouse and human platelets with α- and δ-storage pool diseases

(2019) Sanjeev Kiran Gotru et al.   Scientific Reports

Preferential Presentation of High-Affinity Immune Complexes in Germinal Centers Can Explain How Passive Immunization Improves the Humoral Response

(2019) Amar K. Garg et al.   Cell Reports

Elevated plasma angiotensin converting enzyme 2 activity is an independent predictor of major adverse cardiac events in patients with obstructive coronary artery disease

(2018) Jay Ramchand et al.   PLoS One

Central Composite Design Optimization of Zinc Removal from Contaminated Soil, Using Citric Acid as Biodegradable Chelant

(2018) Farrokh Asadzadeh et al.   Scientific Reports

Crosstalk between zinc and free fatty acids in plasma

(2018) James P.C. Coverdale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

HIBISCUS: Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome

(2018) Cristina Belizna et al.   AUTOIMMUNITY REVIEWS

Dipeptidyl peptidase-4 activity is associated with urine albumin excretion in type 1 diabetes

(2017) Lea Duvnjak et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Prognostic value of serum zinc levels in patients with acute HC/zinc chloride smoke inhalation

(2017) Fei Xie et al.   MEDICINE

A novel mechanism for the pyruvate protection against zinc-induced cytotoxicity: mediation by the chelating effect of citrate and isocitrate

(2016) Jee-Won Sul et al.   ARCHIVES OF PHARMACAL RESEARCH

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Angiotensin converting enzyme 2 activity and human atrial fibrillation: increased plasma angiotensin converting enzyme 2 activity is associated with atrial fibrillation and more advanced left atrial structural remodelling

(2016) Tomos E. Walters et al.   EUROPACE

Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients

(2016) Jae-Hoon Ko et al.   JOURNAL OF INFECTION

Circulating ACE2 activity correlates with cardiovascular disease development

(2016) K. Uri et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Circulating angiotensin-converting enzyme 2 activity in patients with chronic kidney disease without previous history of cardiovascular disease

(2015) Lidia Anguiano et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Shedding of dipeptidyl peptidase 4 is mediated by metalloproteases and up-regulated by hypoxia in human adipocytes and smooth muscle cells

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Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia

(2014) Mustafa Saad et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

New Perspectives in the Renin-Angiotensin-Aldosterone System (RAAS) IV: Circulating ACE2 as a Biomarker of Systolic Dysfunction in Human Hypertension and Heart Failure

(2014) Katalin Úri et al.   PLoS One

Chloroquine Is a Zinc Ionophore

(2014) Jing Xue et al.   PLoS One

Dipeptidyl peptidase IV activity in commercial solutions of human serum albumin

(2013) David Bar-Or et al.   ANALYTICAL BIOCHEMISTRY

Zinc Absorption by Young Adults from Supplemental Zinc Citrate Is Comparable with That from Zinc Gluconate and Higher than from Zinc Oxide

(2013) Rita Wegmüller et al.   JOURNAL OF NUTRITION

Role of Circulating Angiotensin Converting Enzyme 2 in Left Ventricular Remodeling following Myocardial Infarction: A Prospective Controlled Study

(2013) José T. Ortiz-Pérez et al.   PLoS One

Dipeptidyl peptidase-4: A key player in chronic liver disease

(2013) Minoru Itou   WORLD JOURNAL OF GASTROENTEROLOGY

Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications

(2011) Aino Soro-Paavonen et al.   JOURNAL OF HYPERTENSION

Autoantibodies to angiotensin-converting enzyme 2 in patients with connective tissue diseases

(2010) Yuko Takahashi et al.   ARTHRITIS RESEARCH & THERAPY

The Essential Toxin: Impact of Zinc on Human Health

(2010) Laura M. Plum et al.   International Journal of Environmental Research and Public Health

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

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Soluble Angiotensin-Converting Enzyme 2 in Human Heart Failure: Relation With Myocardial Function and Clinical Outcomes

(2009) Slava Epelman et al.   JOURNAL OF CARDIAC FAILURE

Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

(2009) I. Glowacka et al.   JOURNAL OF VIROLOGY

Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor

(2009) K. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of TNF- -converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-  production and facilitates viral entry

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