PDX-Derived Ewing’s Sarcoma Cells Retain High Viability and Disease Phenotype in Alginate Encapsulated Spheroid Cultures

Treatment-driven selection of chemoresistant Ewing sarcoma tumors with limited drug distribution

(2020) Helena Castillo-Ecija et al.   JOURNAL OF CONTROLLED RELEASE

A Sox2–Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells

(2019) Giacomo Domenici et al.   ONCOGENE

Management of recurrent Ewing sarcoma: challenges and approaches

(2019) David Van Mater et al.   OncoTargets and Therapy

3D models in the new era of immune oncology: focus on T cells, CAF and ECM

(2019) Francesca Di Modugno et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Systematic Review of Patient-Derived Xenograft Models for Preclinical Studies of Anti-Cancer Drugs in Solid Tumors

(2019) Yoshikatsu Koga et al.   Cells

Cancer modeling meets human organoid technology

(2019) David Tuveson et al.   SCIENCE

Applications of alginate microspheres in therapeutics delivery and cell culture: Past, present and future

(2019) Dinesh Dhamecha et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations

(2019) Patrizia Nanni et al.   Scientific Reports

Biomechanical regulation of drug sensitivity in an engineered model of human tumor

(2018) A. Marturano-Kruik et al.   BIOMATERIALS

3D-3-culture: A tool to unveil macrophage plasticity in the tumour microenvironment

(2018) Sofia P. Rebelo et al.   BIOMATERIALS

Sarcoma Spheroids and Organoids—Promising Tools in the Era of Personalized Medicine

(2018) Gianluca Colella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glucosylated nanomicelles target glucose-avid pediatric patient-derived sarcomas

(2018) Alexandra Bukchin et al.   JOURNAL OF CONTROLLED RELEASE

The Ewing Sarcoma Secretome and Its Response to Activation of Wnt/beta-catenin Signaling

(2018) Allegra G. Hawkins et al.   MOLECULAR & CELLULAR PROTEOMICS

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Tissue Compatibility of SN-38-Loaded Anticancer Nanofiber Matrices

(2018) Alejandro Manzanares et al.   Advanced Healthcare Materials

The Generation and Application of Patient-Derived Xenograft Model for Cancer Research

(2018) Jaeyun Jung et al.   Cancer Research and Treatment

Ewing sarcoma

(2018) Thomas G. P. Grünewald et al.   Nature Reviews Disease Primers

The combination of epigenetic drugs SAHA and HCI-2509 synergistically inhibits EWS-FLI1 and tumor growth in Ewing sarcoma

(2018) Daniel Jose García-Domínguez et al.   Oncotarget

Preclinical efficacy of endoglin-targeting antibody-drug conjugates for the treatment of Ewing sarcoma

(2018) Pilar Puerto-Camacho et al.   CLINICAL CANCER RESEARCH

Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids

(2017) Stephen Riffle et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

(2017) Chantal Pauli et al.   Cancer Discovery

Three-Dimensional Patient-Derived In Vitro Sarcoma Models: Promising Tools for Improving Clinical Tumor Management

(2017) Manuela Gaebler et al.   Frontiers in Oncology

Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression

(2016) Marta F. Estrada et al.   BIOMATERIALS

Establishment and molecular characterisation of seven novel soft-tissue sarcoma cell lines

(2016) Abdulazeez Salawu et al.   BRITISH JOURNAL OF CANCER

Docetaxel, bevacizumab, and gemcitabine for very high risk sarcomas in adolescents and young adults: A single-center experience

(2016) Christopher Kuo et al.   PEDIATRIC BLOOD & CANCER

Rhabdomyosarcoma

(2016) Roshni Dasgupta et al.   Seminars in Pediatric Surgery

Potential approaches to the treatment of Ewing’s sarcoma

(2016) Hongjiu Yu et al.   Oncotarget

Prognosis value of Hypoxia-inducible factor-1α expression in patients with bone and soft tissue sarcoma: a meta-analysis

(2016) Yongjiang Li et al.   SpringerPlus

Quantitation of Murine Stroma and Selective Purification of the Human Tumor Component of Patient-Derived Xenografts for Genomic Analysis

(2016) Valentina E. Schneeberger et al.   PLoS One

Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

(2016) Kristin Stock et al.   Scientific Reports

Alginates in Pharmaceutics and Biomedicine: Is the Future so Bright?

(2015) Stefano Giovagnoli et al.   CURRENT PHARMACEUTICAL DESIGN

Associations of chemo- and radio-resistant phenotypes with the gap junction, adhesion and extracellular matrix in a three-dimensional culture model of soft sarcoma

(2015) Chujie Bai et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma

(2015) Marco Santoro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin

(2015) José Luis Ordóñez et al.   Oncotarget

Microenvironmental Targets in Sarcoma

(2015) Monika Ehnman et al.   Frontiers in Oncology

A study of docetaxel and irinotecan in children and young adults with recurrent or refractory Ewing sarcoma family of tumors

(2014) Jong Hyung Yoon et al.   BMC CANCER

Anchorage-independent growth of Ewing sarcoma cells under serum-free conditions is not associated with stem-cell like phenotype and function

(2014) KATHARINA LEUCHTE et al.   ONCOLOGY REPORTS

Engineered Culture Models for Studies of Tumor-Microenvironment Interactions

(2013) David W. Infanger et al.   Annual Review of Biomedical Engineering

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Modeling Ewing sarcoma tumors in vitro with 3D scaffolds

(2013) E. L. S. Fong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Technologies for deriving primary tumor cells for use in personalized cancer therapy

(2013) Abhisek Mitra et al.   TRENDS IN BIOTECHNOLOGY

Comparison between fibroblasts and mesenchymal stem cells derived from dermal and adipose tissue

(2013) C. A. Brohem et al.   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

Macrophage Infiltration Predicts a Poor Prognosis for Human Ewing Sarcoma

(2011) Toshifumi Fujiwara et al.   AMERICAN JOURNAL OF PATHOLOGY

Characteristics of human Ewing/PNET sarcoma models

(2011) BeverlyA Teicher et al.   ANNALS OF SAUDI MEDICINE

Molecular Pathogenesis of Ewing Sarcoma: New Therapeutic and Transcriptional Targets

(2011) Stephen L. Lessnick et al.   Annual Review of Pathology-Mechanisms of Disease

Real-time PCR-based assay to quantify the relative amount of human and mouse tissue present in tumor xenografts

(2011) Sergio Y Alcoser et al.   BMC BIOTECHNOLOGY

Quantifying the relative amount of mouse and human DNA in cancer xenografts using species-specific variation in gene length

(2010) Ming-Tseh Lin et al.   BIOTECHNIQUES

Guidelines for the welfare and use of animals in cancer research

(2010) P Workman et al.   BRITISH JOURNAL OF CANCER

Hypoxia Modulates EWS-FLI1 Transcriptional Signature and Enhances the Malignant Properties of Ewing's Sarcoma Cells In vitro

(2010) D. N. T. Aryee et al.   CANCER RESEARCH

Oncogenic Partnerships: EWS-FLI1 Protein Interactions Initiate Key Pathways of Ewing's Sarcoma

(2010) H. V. Erkizan et al.   CLINICAL CANCER RESEARCH

Pro-inflammatory chemokine-chemokine receptor interactions within the Ewing sarcoma microenvironment determine CD8+ T-lymphocyte infiltration and affect tumour progression

(2010) Dagmar Berghuis et al.   JOURNAL OF PATHOLOGY

Irinotecan and temozolomide for Ewing sarcoma: The Memorial Sloan-Kettering experience

(2009) Denise A. Casey et al.   PEDIATRIC BLOOD & CANCER

DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing's tumor cells

(2008) E García-Aragoncillo et al.   ONCOGENE