Implications of Endogenous Retroelements in the Etiopathogenesis of Systemic Lupus Erythematosus

The contribution of HERV‐E clone 4‐1 and other HERV‐E members to the pathogenesis of rheumatic autoimmune diseases

(2020) Rossella Talotta et al.   APMIS

Long INterspersed element‐1 mobility as a sensor of environmental stresses

(2020) Brunella Del Re et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

(2020) Huipeng Jiao et al.   NATURE

Gut stem cell necroptosis by genome instability triggers bowel inflammation

(2020) Ruicong Wang et al.   NATURE

Human Endogenous Retrovirus K (HML-2) in Health and Disease

(2020) Bei Xue et al.   Frontiers in Microbiology

Adenosine-to-Inosine RNA Editing of Alu Double-Stranded (ds)RNAs Is Markedly Decreased in Multiple Sclerosis and Unedited Alu dsRNAs Are Potent Activators of Proinflammatory Transcriptional Responses

(2020) John T. Tossberg et al.   JOURNAL OF IMMUNOLOGY

LINE-2 transposable elements are a source of functional human microRNAs and target sites

(2019) Rebecca Petri et al.   PLoS Genetics

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

Safety and tolerability of anifrolumab, a monoclonal antibody targeting type I interferon receptor, in Japanese patients with systemic lupus erythematosus: A multicenter, phase 2, open-label study

(2019) Yoshiya Tanaka et al.   Modern Rheumatology

Endogenous double-stranded Alu RNA elements stimulate IFN-responses in relapsing remitting multiple sclerosis

(2019) Maxwell J. Heinrich et al.   JOURNAL OF AUTOIMMUNITY

The study of interactions between genome and exposome in the development of systemic lupus erythematosus

(2019) Henrik Christian Bidstrup Leffers et al.   AUTOIMMUNITY REVIEWS

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus

(2019) Simon H. Jiang et al.   Nature Communications

High prevalence and disease correlation of autoantibodies against p40 encoded by long interspersed nuclear elements ( LINE ‐1) in systemic lupus erythematosus

(2019) Victoria Carter et al.   Arthritis & Rheumatology

Sources of Pathogenic Nucleic Acids in Systemic Lupus Erythematosus

(2019) Tomas Mustelin et al.   Frontiers in Immunology

Mobile DNA in Endocrinology: LINE-1 retrotransposon causing Partial Androgen Insensitivity Syndrome

(2019) Rafael Loch Batista et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Expression of human endogenous retroviruses in pemphigus vulgaris patients

(2019) Abbas Karimi et al.   MOLECULAR BIOLOGY REPORTS

IgG reactive with the p40 protein encoded by the LINE‐1 retroelement

(2019) Mary K. Crow   Arthritis & Rheumatology

LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways

(2018) Ke Zhao et al.   JOURNAL OF AUTOIMMUNITY

TBK1: A key regulator and potential treatment target for interferon positive Sjögren's syndrome, systemic lupus erythematosus and systemic sclerosis

(2018) Iris L.A. Bodewes et al.   JOURNAL OF AUTOIMMUNITY

Defective regulation of L1 endogenous retroelements in primary Sjogren's syndrome and systemic lupus erythematosus: Role of methylating enzymes

(2018) Clio P. Mavragani et al.   JOURNAL OF AUTOIMMUNITY

Interplay between RNASEH2 and MOV10 controls LINE-1 retrotransposition

(2018) Jongsu Choi et al.   NUCLEIC ACIDS RESEARCH

Transposable element dysregulation in systemic lupus erythematosus and regulation by histone conformation and Hsp90

(2018) Maurer Kelly et al.   CLINICAL IMMUNOLOGY

The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors

(2018) Huan Lian et al.   IMMUNITY

Human Endogenous Retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model

(2018) Timokratis Karamitros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites

(2018) Meagan Montesion et al.   Retrovirology

ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

(2018) Huan Lian et al.   Nature Communications

Human endogenous retrovirus-K (HML-2): a comprehensive review

(2018) Marta Garcia-Montojo et al.   CRITICAL REVIEWS IN MICROBIOLOGY

PD-1 immunobiology in systemic lupus erythematosus

(2018) Colleen S. Curran et al.   JOURNAL OF AUTOIMMUNITY

Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome

(2018) Gillian I. Rice et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prenatal airborne polycyclic aromatic hydrocarbon exposure, LINE1 methylation and child development in a Chinese cohort

(2017) Joan Lee et al.   ENVIRONMENT INTERNATIONAL

LINE-1 retrotransposon-mediated DNA transductions in endometriosis associated ovarian cancers

(2017) Zhouchunyang Xia et al.   GYNECOLOGIC ONCOLOGY

Disease-associated mutations identify a novel region in human STING necessary for the control of type I interferon signaling

(2017) Isabelle Melki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Detection of interferon alpha protein reveals differential levels and cellular sources in disease

(2017) Mathieu P. Rodero et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion

(2017) Peng Li et al.   NUCLEIC ACIDS RESEARCH

PIWIs, piRNAs and Retrotransposons: Complex battles during reprogramming in gametes and early embryos

(2017) SJ Russell et al.   REPRODUCTION IN DOMESTIC ANIMALS

Decreased mRNA expression levels of DNA methyltransferases type 1 and 3A in systemic lupus erythematosus

(2017) Mariusz J. Nawrocki et al.   RHEUMATOLOGY INTERNATIONAL

Identification of pathogenic retrotransposon insertions in cancer predisposition genes

(2017) Yaping Qian et al.   Cancer Genetics

Expression of Cyclic GMP-AMP Synthase in Patients With Systemic Lupus Erythematosus

(2017) Jie An et al.   Arthritis & Rheumatology

Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway

(2017) Kit San Yeung et al.   PLoS One

Sifalimumab, an anti-interferon-α monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study

(2016) Munther Khamashta et al.   ANNALS OF THE RHEUMATIC DISEASES

Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren's syndrome reveals regulatory effects at interferon-induced genes

(2016) Juliana Imgenberg-Kreuz et al.   ANNALS OF THE RHEUMATIC DISEASES

Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

(2016) Romain Banchereau et al.   CELL

Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children’s Health Study

(2016) Carrie V. Breton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A hot L1 retrotransposon evades somatic repression and initiates human colorectal cancer

(2016) Emma C. Scott et al.   GENOME RESEARCH

RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice

(2016) Vladislav Pokatayev et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Retrotransposons as regulators of gene expression

(2016) R. A. Elbarbary et al.   SCIENCE

Multiple LINEs of retrotransposon silencing mechanisms in the mammalian germline

(2016) Fang Yang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells

(2016) Fuling Zhou et al.   Oncotarget

Roles for retrotransposon insertions in human disease

(2016) Dustin C. Hancks et al.   Mobile DNA

Prion-like Aggregation of Mitochondrial Antiviral Signaling Protein in Lupus Patients Is Associated With Increased Levels of Type I Interferon

(2016) Wen-Hai Shao et al.   Arthritis & Rheumatology

Expression of Long Interspersed Nuclear Element 1 Retroelements and Induction of Type I Interferon in Patients With Systemic Autoimmune Disease

(2016) Clio P. Mavragani et al.   Arthritis & Rheumatology

Guardian of the Human Genome: Host Defense Mechanisms against LINE-1 Retrotransposition

(2016) Yasuo Ariumi   Frontiers in Chemistry

Characterization of human disease phenotypes associated with mutations inTREX1,RNASEH2A,RNASEH2B,RNASEH2C,SAMHD1,ADAR, andIFIH1

(2015) Yanick J. Crow et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A Phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE)

(2015) Kenneth C Kalunian et al.   ANNALS OF THE RHEUMATIC DISEASES

MILI, a PIWI family protein, inhibits melanoma cell migration through methylation of LINE1

(2015) Xiuxing Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response

(2015) Clément Jacquemin et al.   IMMUNITY

Human autoimmune diseases: a comprehensive update

(2015) Lifeng Wang et al.   JOURNAL OF INTERNAL MEDICINE

Human endogenous retrovirus HERV-K(HML-2) activity in prostate cancer is dominated by a few loci

(2015) Wolfgang Goering et al.   PROSTATE

The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression

(2015) T. Hung et al.   SCIENCE

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome

(2015) Yoong Wearn Lim et al.   eLife

Crossing the LINE Toward Genomic Instability: LINE-1 Retrotransposition in Cancer

(2015) Jacqueline R. Kemp et al.   Frontiers in Chemistry

Long Interspersed Element-1 Protein Expression Is a Hallmark of Many Human Cancers

(2014) Nemanja Rodić et al.   AMERICAN JOURNAL OF PATHOLOGY

Types of DNA methylation status of the interspersed repetitive sequences for LINE-1, Alu, HERV-E and HERV-K in the neutrophils from systemic lupus erythematosus patients and healthy controls

(2014) Patadon Sukapan et al.   JOURNAL OF HUMAN GENETICS

Cutting Edge: Autoimmune Disease Risk Variant of STAT4 Confers Increased Sensitivity to IFN-  in Lupus Patients In Vivo

(2014) S. N. Kariuki et al.   JOURNAL OF IMMUNOLOGY

Affinity Proteomics Reveals Human Host Factors Implicated in Discrete Stages of LINE-1 Retrotransposition

(2013) Martin S. Taylor et al.   CELL

Advances in lupus genetics

(2013) Susan A. Boackle   CURRENT OPINION IN RHEUMATOLOGY

Epigenetics in the pathogenesis of systemic lupus erythematosus

(2013) Nezam Altorok et al.   CURRENT OPINION IN RHEUMATOLOGY

Hypomethylation of long interspersed nucleotide element-1 in peripheral mononuclear cells of juvenile systemic lupus erythematosus patients in China

(2013) Xiaolan Huang et al.   International Journal of Rheumatic Diseases

The MOV10 Helicase Inhibits LINE-1 Mobility

(2013) Xiaoyu Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical Sub-Phenotypes

(2013) Bahram Namjou et al.   PLoS One

Dissecting complex epigenetic alterations in human lupus

(2013) Dipak R Patel et al.   ARTHRITIS RESEARCH & THERAPY

HERV-K(HML-2), the Best Preserved Family of HERVs: Endogenization, Expression, and Implications in Health and Disease

(2013) Oliver Hohn et al.   Frontiers in Oncology

Recent insights into the genetic basis of systemic lupus erythematosus

(2012) Ornella Josephine Rullo et al.   ANNALS OF THE RHEUMATIC DISEASES

Endogenous retroelements and autoimmune disease

(2012) Daniel B Stetson   CURRENT OPINION IN IMMUNOLOGY

The genetics of type I interferon in systemic lupus erythematosus

(2012) Paola G Bronson et al.   CURRENT OPINION IN IMMUNOLOGY

A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?

(2012) Arkarachai Fungtammasan et al.   GENOME RESEARCH

Common Fragile Sites: Genomic Hotspots of DNA Damage and Carcinogenesis

(2012) Ke Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus

(2012) Dong-Qing Ye   Molecular Medicine Reports

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

MicroRNAs—novel regulators of systemic lupus erythematosus pathogenesis

(2012) Nan Shen et al.   Nature Reviews Rheumatology

Acute stress and hippocampal histone H3 lysine 9 trimethylation, a retrotransposon silencing response

(2012) R. G. Hunter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous MOV10 inhibits the retrotransposition of endogenous retroelements but not the replication of exogenous retroviruses

(2012) Shetal Arjan-Odedra et al.   Retrovirology

Genes, epigenetic regulation and environmental factors: Which is the most relevant in developing autoimmune diseases?

(2011) Karen H. Costenbader et al.   AUTOIMMUNITY REVIEWS

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

(2011) B Namjou et al.   GENES AND IMMUNITY

Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus

(2011) Sulaiman M Al-Mayouf et al.   NATURE GENETICS

Human Endogenous Retrovirus K106 (HERV-K106) Was Infectious after the Emergence of Anatomically Modern Humans

(2011) Aashish R. Jha et al.   PLoS One

Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses

(2011) Ravi P Subramanian et al.   Retrovirology

Alu elements: know the SINEs

(2011) Prescott Deininger   GENOME BIOLOGY

Endogenous retroviral pathogenesis in lupus

(2010) Andras Perl et al.   CURRENT OPINION IN RHEUMATOLOGY

Long interspersed nuclear elements (LINE-1): Potential triggers of systemic autoimmune disease

(2009) Mary K. Crow   AUTOIMMUNITY

Type I interferon and lupus

(2009) Lars Rönnblom et al.   CURRENT OPINION IN RHEUMATOLOGY

L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism

(2009) H. Kano et al.   GENES & DEVELOPMENT

Review of recent genome-wide association scans in lupus

(2009) R. R. Graham et al.   JOURNAL OF INTERNAL MEDICINE

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases

(2009) et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increase in Human Endogenous Retrovirus HERV-K (HML-2) Viral Load in Active Rheumatoid Arthritis

(2009) F. Reynier et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

High-Density SNP Screening of the Major Histocompatibility Complex in Systemic Lupus Erythematosus Demonstrates Strong Evidence for Independent Susceptibility Regions

(2009) Lisa F. Barcellos et al.   PLoS Genetics

Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus

(2008) Rudolf Pullmann et al.   ARTHRITIS AND RHEUMATISM

Association of the IRF5 risk haplotype with high serum interferon-α activity in systemic lupus erythematosus patients

(2008) Timothy B. Niewold et al.   ARTHRITIS AND RHEUMATISM

ThePTPN22C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-α activity and low tumor necrosis factor α levels in patients with lupus

(2008) Silvia N. Kariuki et al.   ARTHRITIS AND RHEUMATISM

Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLE

(2008) Andras Perl et al.   AUTOIMMUNITY

SnapShot: Vertebrate Transposons

(2008) Prabhat K. Mandal et al.   CELL

Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites

(2008) John L. Goodier et al.   CELL

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes

(2008) S. Kuramochi-Miyagawa et al.   GENES & DEVELOPMENT

A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus

(2008) V. Orru et al.   HUMAN MOLECULAR GENETICS

Human endogenous retrovirus HERV-K113 is capable of producing intact viral particles

(2008) K. Boller et al.   JOURNAL OF GENERAL VIROLOGY

A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

(2008) Swapan K Nath et al.   NATURE GENETICS

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

(2008) Sergey V Kozyrev et al.   NATURE GENETICS

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

(2008) Geoffrey Hom et al.   NEW ENGLAND JOURNAL OF MEDICINE