Advances in lupus genetics

Complement Receptor 3 Influences Toll-like Receptor 7/8-Dependent Inflammation

(2013) Joanne H. Reed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phagocytosis Is the Main CR3-Mediated Function Affected by the Lupus-Associated Variant of CD11b in Human Myeloid Cells

(2013) Liliane Fossati-Jimack et al.   PLoS One

Evidence of New Risk Genetic Factor to Systemic Lupus Erythematosus: The UBASH3A Gene

(2013) Lina-Marcela Diaz-Gallo et al.   PLoS One

Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production

(2013) Julio E. Molineros et al.   PLoS Genetics

Genetically Determined Partial Complement C4 Deficiency States Are Not Independent Risk Factors for SLE in UK and Spanish Populations

(2012) Lora Boteva et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Unraveling Multiple MHC Gene Associations with Systemic Lupus Erythematosus: Model Choice Indicates a Role for HLA Alleles and Non-HLA Genes in Europeans

(2012) David L. Morris et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a Large-Scale Multiracial Replication Study

(2012) Christopher J. Lessard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genomic Pathology of SLE-Associated Copy-Number Variation at the FCGR2C/FCGR3B/FCGR2B Locus

(2012) Michael Mueller et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians

(2012) Wanling Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein

(2012) Angélica M Delgado-Vega et al.   ANNALS OF THE RHEUMATIC DISEASES

Variation in theICAM1–ICAM4–ICAM5locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries

(2012) Kwangwoo Kim et al.   ANNALS OF THE RHEUMATIC DISEASES

Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci atMSH5, HLA-DPB1andHLA-G

(2012) Michelle M A Fernando et al.   ANNALS OF THE RHEUMATIC DISEASES

Thers1143679(R77H) lupus associated variant ofITGAM(CD11b) impairs complement receptor 3 mediated functions in human monocytes

(2012) Benjamin Rhodes et al.   ANNALS OF THE RHEUMATIC DISEASES

European genetic ancestry is associated with a decreased risk of lupus nephritis

(2012) Ilana B. Richman et al.   ARTHRITIS AND RHEUMATISM

Brief Report: Single-nucleotide polymorphisms inVKORC1are risk factors for systemic lupus erythematosus in Asians

(2012) Rachel Kaiser et al.   ARTHRITIS AND RHEUMATISM

Brief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus

(2012) Tharian S. Cherian et al.   ARTHRITIS AND RHEUMATISM

Evaluation ofTRAF6in a large multiancestral lupus cohort

(2012) Bahram Namjou et al.   ARTHRITIS AND RHEUMATISM

Association of two independent functional risk haplotypes inTNIP1with systemic lupus erythematosus

(2012) Indra Adrianto et al.   ARTHRITIS AND RHEUMATISM

An intronic variant associated with systemic lupus erythematosus changes the binding affinity of Yinyang1 to downregulate WDFY4

(2012) H Zhao et al.   GENES AND IMMUNITY

Association of AFF1 rs340630 and AFF3 rs10865035 polymorphisms with systemic lupus erythematosus in a Chinese population

(2012) Han Cen et al.   IMMUNOGENETICS

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation

(2012) Nataly Manjarrez-Orduño et al.   NATURE GENETICS

Gene–Gene and Gene-Sex Epistatic Interactions of MiR146a, IRF5, IKZF1, ETS1 and IL21 in Systemic Lupus Erythematosus

(2012) Rui-Xue Leng et al.   PLoS One

The genetics of lupus: a functional perspective

(2012) Sandra G Guerra et al.   ARTHRITIS RESEARCH & THERAPY

A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese

(2012) Yukinori Okada et al.   PLoS Genetics

Analysis of autosomal genes reveals gene–sex interactions and higher total genetic risk in men with systemic lupus erythematosus

(2011) Travis Hughes et al.   ANNALS OF THE RHEUMATIC DISEASES

IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus

(2011) Timothy B Niewold et al.   ANNALS OF THE RHEUMATIC DISEASES

Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, and REL in systemic lupus erythematosus

(2011) Xu-jie Zhou et al.   ARTHRITIS AND RHEUMATISM

Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus

(2011) Travis Hughes et al.   ARTHRITIS AND RHEUMATISM

Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis

(2011) C P Lin et al.   GENES AND IMMUNITY

Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase

(2011) C. O. Jacob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Risk Alleles for Systemic Lupus Erythematosus in a Large Case-Control Collection and Associations with Clinical Subphenotypes

(2011) Kimberly E. Taylor et al.   PLoS Genetics

Evidence for both copy number and allelic (NA1/NA2) risk at the FCGR3B locus in systemic lupus erythematosus

(2010) David L Morris et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Association of ITGAM polymorphism with systemic lupus erythematosus: a meta-analysis

(2010) Y Fan et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus

(2010) Wanling Yang et al.   PLoS Genetics

Impaired differentiation and cytotoxicity of natural killer cells in systemic lupus erythematosus

(2009) Yong-Wook Park et al.   ARTHRITIS AND RHEUMATISM

Evaluation of imputation-based association in and around the integrin- -M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE)

(2009) S. Han et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Copy number ofFCGR3B,which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake

(2008) Lisa C. Willcocks et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

(2008) Swapan K Nath et al.   NATURE GENETICS

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

(2008) Geoffrey Hom et al.   NEW ENGLAND JOURNAL OF MEDICINE