Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

(2020) Defne Bayik et al.   Cancer Discovery

T-cells produce acidic niches in lymph nodes to suppress their own effector functions

(2020) Hao Wu et al.   Nature Communications

Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma

(2019) Junfei Zhao et al.   NATURE MEDICINE

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

(2019) Timothy F. Cloughesy et al.   NATURE MEDICINE

Brain Tumor Microenvironment and Host State: Implications for Immunotherapy

(2019) William Tomaszewski et al.   CLINICAL CANCER RESEARCH

Extrinsic acidosis suppresses glycolysis and migration while increasing network formation in pulmonary microvascular endothelial cells

(2019) Ji Young Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

(2019) Daniel J. Puleston et al.   Cell Metabolism

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma

(2019) Jason Miska et al.   Cell Reports

Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide

(2019) Chanju Lee et al.   Journal for ImmunoTherapy of Cancer

Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

(2019) Michal Harel et al.   CELL

Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial

(2019) E. Antonio Chiocca et al.   Science Translational Medicine

Myeloid-derived suppressive cells promote B cell-mediated immunosuppression via transfer of PD-L1 in glioblastoma

(2019) Catalina Lee-Chang et al.   Cancer Immunology Research

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells

(2019) Eric H. Ma et al.   IMMUNITY

Therapeutic targeting of tumor-associated myeloid cells synergizes with radiation therapy for glioblastoma

(2019) Peng Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

GCN2 is essential for CD8+ T cell survival and function in murine models of malignant glioma

(2019) Aida Rashidi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tu1857 - Ornithine Decarboxylase in Macrophages Exacerbates Acute Colitis and Colitis-Associated Carcinogenesis by Impairing M1 Innate Immune Responses

(2018) Kshipra Singh et al.   GASTROENTEROLOGY

The Immune Landscape of Cancer

(2018) Vésteinn Thorsson et al.   IMMUNITY

Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment

(2018) Suzanne Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Polyamines: Bio-Molecules with Diverse Functions in Plant and Human Health and Disease

(2018) Avtar K. Handa et al.   Frontiers in Chemistry

Single-cell transcriptome analysis of lineage diversity in high-grade glioma

(2018) Jinzhou Yuan et al.   Genome Medicine

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages

(2018) Toszka Bohn et al.   NATURE IMMUNOLOGY

Immunosuppressive Myeloid Cells’ Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy

(2017) Neha Kamran et al.   MOLECULAR THERAPY

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

(2017) Dana M. Hardbower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Exhaustion in Glioblastoma: Intricacies of Immune Checkpoints

(2017) Reza Mirzaei et al.   TRENDS IN IMMUNOLOGY

A novel polyamine blockade therapy activates an anti-tumor immune response

(2017) Eric T. Alexander et al.   Oncotarget

A Comparative Study of Replication-Incompetent and -Competent Adenoviral Therapy-Mediated Immune Response in a Murine Glioma Model

(2017) Julius W. Kim et al.   Molecular Therapy-Oncolytics

Anti-GITR therapy promotes immunity against malignant glioma in a murine model

(2016) Jason Miska et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

(2016) Alan L. Chang et al.   CANCER RESEARCH

Imaging the intratumoral-peritumoral extracellular pH gradient of gliomas

(2016) Daniel Coman et al.   NMR IN BIOMEDICINE

Probe for the measurement of cell surface pH in vivo and ex vivo

(2016) Michael Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma

(2015) Roger Stupp et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Targeting Ornithine Decarboxylase by α-Difluoromethylornithine Inhibits Tumor Growth by Impairing Myeloid-Derived Suppressor Cells

(2015) Cong Ye et al.   JOURNAL OF IMMUNOLOGY

Extracellular acidity, a “reappreciated” trait of tumor environment driving malignancy: perspectives in diagnosis and therapy

(2014) Silvia Peppicelli et al.   CANCER AND METASTASIS REVIEWS

The Polyamine Catabolic Enzyme SAT1 Modulates Tumorigenesis and Radiation Response in GBM

(2014) A. Brett-Morris et al.   CANCER RESEARCH

Photon upconversion sensitized nanoprobes for sensing and imaging of pH

(2014) Riikka Arppe et al.   Nanoscale

Beyond Warburg effect – dual metabolic nature of cancer cells

(2014) Jiansheng Xie et al.   Scientific Reports

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

GM-CSF Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor- 

(2013) G. Kohanbash et al.   CANCER RESEARCH

Regulation of inflammation by extracellular acidification and proton-sensing GPCRs

(2013) Fumikazu Okajima   CELLULAR SIGNALLING

Profound Impairment of Adaptive Immune Responses by Alkylating Chemotherapy

(2013) A. J. Litterman et al.   JOURNAL OF IMMUNOLOGY

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells

(2013) S. Mandal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyamine-Blocking Therapy Reverses Immunosuppression in the Tumor Microenvironment

(2013) C. S. Hayes et al.   Cancer Immunology Research

Involvement of tumor acidification in brain cancer pathophysiology

(2013) Avinash Honasoge et al.   Frontiers in Physiology

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

(2012) A. Calcinotto et al.   CANCER RESEARCH

Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma

(2012) ARNULF MAYER et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Function of carbonic anhydrase IX in glioblastoma multiforme

(2012) M. A. Proescholdt et al.   NEURO-ONCOLOGY

Neutrophil Degranulation and Immunosuppression in Patients with GBM: Restoration of Cellular Immune Function by Targeting Arginase I

(2011) T. R. Sippel et al.   CLINICAL CANCER RESEARCH

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

(2010) Johanna Chiche et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The early history of polyamine research

(2010) Uriel Bachrach   PLANT PHYSIOLOGY AND BIOCHEMISTRY

The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths

(2009) Pawel Swietach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-Mediated Induction of the Polyamine System Provides Opportunities for Tumor Growth Inhibition by Combined Targeting of Vascular Endothelial Growth Factor and Ornithine Decarboxylase

(2008) K. J. Svensson et al.   CANCER RESEARCH

Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas

(2008) Joonas Haapasalo et al.   NEURO-ONCOLOGY