Anti-GITR therapy promotes immunity against malignant glioma in a murine model

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

(2016) Mira A. Patel et al.   Journal for ImmunoTherapy of Cancer

Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma

(2015) Elias J. Sayour et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Regulatory T cells are not a strong predictor of survival for patients with glioblastoma

(2015) A. A. Thomas et al.   NEURO-ONCOLOGY

Dendritic Cell-Based Immunotherapy Treatment for Glioblastoma Multiforme

(2015) Liu Yang et al.   Biomed Research International

Immune modulation for cancer therapy

(2014) J Naidoo et al.   BRITISH JOURNAL OF CANCER

Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors

(2014) D. A. Wainwright et al.   CLINICAL CANCER RESEARCH

Targeting regulatory T cells in tumor immunotherapy

(2014) Mark J Smyth et al.   IMMUNOLOGY AND CELL BIOLOGY

Gene Expression in the Gitr Locus Is Regulated by NF- B and Foxp3 through an Enhancer

(2014) Y. Tone et al.   JOURNAL OF IMMUNOLOGY

Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs

(2014) Lei Lu et al.   Journal of Translational Medicine

Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody

(2014) Bryan D Choi et al.   OncoImmunology

Regulatory T cell subsets in human cancer: are they regulating for or against tumor progression?

(2013) Theresa L. Whiteside   CANCER IMMUNOLOGY IMMUNOTHERAPY

Depletion of Regulatory T Cells in a Mouse Experimental Glioma Model through Anti-CD25 Treatment Results in the Infiltration of Non-Immunosuppressive Myeloid Cells in the Brain

(2013) Wim Maes et al.   Clinical & Developmental Immunology

Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas

(2013) Jing Zeng et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

(2013) Yannick Bulliard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell–mediated glioma rejection

(2013) Johannes vom Berg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The prognostic value of Foxp3+ tumor-infiltrating lymphocytes in patients with glioblastoma

(2013) Qi Yue et al.   JOURNAL OF NEURO-ONCOLOGY

Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model

(2013) Mahua Dey et al.   JOURNAL OF NEUROIMMUNOLOGY

GITR Pathway Activation Abrogates Tumor Immune Suppression through Loss of Regulatory T-cell Lineage Stability

(2013) D. A. Schaer et al.   Cancer Immunology Research

Targeting Tregs in Malignant Brain Cancer: Overcoming IDO

(2013) Derek A. Wainwright et al.   Frontiers in Immunology

IDO Expression in Brain Tumors Increases the Recruitment of Regulatory T Cells and Negatively Impacts Survival

(2012) D. A. Wainwright et al.   CLINICAL CANCER RESEARCH

The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells

(2012) Dennis Lindau et al.   IMMUNOLOGY

Optimized Staining and Proliferation Modeling Methods for Cell Division Monitoring using Cell Tracking Dyes

(2012) Joseph D. Tario et al.   Jove-Journal of Visualized Experiments

Monoclonal antibodies in neuro-oncology

(2011) Lois A. Lampson   mAbs

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors

(2011) Derek A. Wainwright et al.   NEURO-ONCOLOGY

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prognostic significance and mechanism of Treg infiltration in human brain tumors

(2010) Joannes F.M. Jacobs et al.   JOURNAL OF NEUROIMMUNOLOGY

Immunotherapy coming of age: What will it take to make it standard of care for glioblastoma?

(2010) A. B. Heimberger et al.   NEURO-ONCOLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor-Derived Microvesicles Induce, Expand and Up-Regulate Biological Activities of Human Regulatory T Cells (Treg)

(2010) Marta Szajnik et al.   PLoS One

The GITRL–GITR system alters TLR-4 expression on DC during fungal infection

(2009) Anna Vecchiarelli et al.   CELLULAR IMMUNOLOGY

Regulatory T cells: how do they suppress immune responses?

(2009) S. Sakaguchi et al.   INTERNATIONAL IMMUNOLOGY

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

(2009) S. Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

The Role of Tregs in Human Glioma Patients and their Inhibition with a Novel STAT-3 Inhibitor

(2009) Mohamed Abou-Ghazal et al.   NEUROSURGERY

Combating immunosuppression in glioma

(2008) Eleanor A Vega et al.   Future Oncology