An inherent dysfunction in soluble guanylyl cyclase is present in the airway of severe asthmatics and is associated with aberrant redox enzyme expression and compromised NO-cGMP signaling

Recent findings in the genetics and epigenetics of asthma and allergy

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GAPDH Delivers Heme to Soluble Guanylyl Cyclase

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Soluble Guanylate Cyclase Agonists Induce Bronchodilation in Human Small Airways

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A New Pathway to Airway Relaxation - Targeting the “Other” Cyclase in Asthma

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A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle

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Redox control of vascular smooth muscle cell function and plasticity

(2018) Brittany G. Durgin et al.   LABORATORY INVESTIGATION

Redox regulation of soluble guanylyl cyclase

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Handling heme: The mechanisms underlying the movement of heme within and between cells

(2018) Rebecca K. Donegan et al.   FREE RADICAL BIOLOGY AND MEDICINE

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Guanylyl cyclase sensitivity to nitric oxide is protected by a thiol oxidation-driven interaction with thioredoxin-1

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Irreversible Activation and Stabilization of Soluble Guanylate Cyclase by the Protoporphyrin IX Mimetic Cinaciguat

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Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease

(2016) Y. S. Prakash   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma

(2016) Arnab Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is enhancing cGMP-PKG signalling a promising therapeutic target for heart failure with preserved ejection fraction?

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Defective Resensitization in Human Airway Smooth Muscle Cells Evokes β-Adrenergic Receptor Dysfunction in Severe Asthma

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Asthma

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New insights into the role of soluble guanylate cyclase in blood pressure regulation

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Nitric Oxide and Heat Shock Protein 90 Activate Soluble Guanylate Cyclase by Driving Rapid Change in Its Subunit Interactions and Heme Content

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A Review on Hemeoxygenase-2: Focus on Cellular Protection and Oxygen Response

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Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

(2014) Deborah Chiabrando et al.   Frontiers in Pharmacology

The Chemistry and Biology of Soluble Guanylate Cyclase Stimulators and Activators

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International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

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Airway smooth muscle in the pathophysiology and treatment of asthma

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The airway epithelium in asthma

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Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme

(2012) A. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cAMP regulation of airway smooth muscle function

(2012) Charlotte K. Billington et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Soluble Guanylate Cyclase as an Emerging Therapeutic Target in Cardiopulmonary Disease

(2011) Johannes-Peter Stasch et al.   CIRCULATION

Thioredoxin Reductase Inhibition Reduces Relaxation By Increasing Oxidative Stress and S-Nitrosylation in Mouse Aorta

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Fluorescence Dequenching Makes Haem-Free Soluble Guanylate Cyclase Detectable in Living Cells

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Oxidative Stress in Asthma

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Interferons modulate mitogen-induced protein synthesis in airway smooth muscle

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Redox Control of Asthma: Molecular Mechanisms and Therapeutic Opportunities

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Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation

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Nitric Oxide–Independent Vasodilator Rescues Heme-Oxidized Soluble Guanylate Cyclase From Proteasomal Degradation

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Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics

(2009) Emily J. Tsai et al.   PHARMACOLOGY & THERAPEUTICS

Heme oxygenase-1 induction depletes heme and attenuates pulmonary artery relaxation and guanylate cyclase activation by nitric oxide

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Comparisons of effects of intravenous and inhaled methacholine on airway physiology in a murine asthma model

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