Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer

Membrane-Tethered MUC1 Mucin Counter-Regulates the Phagocytic Activity of Macrophages

(2016) Kosuke Kato et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The MUC1 mucin specifically inhibits activation of the NLRP3 inflammasome

(2016) G Z Ng et al.   GENES AND IMMUNITY

Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB

(2016) Micaela Morgado et al.   Oncotarget

Genetic variations of MUC17 are associated with endometriosis development and related infertility

(2015) Ching-Wen Yang et al.   BMC Medical Genetics

Penetrability of the inner mucus layer: who is out there?

(2015) H. Li et al.   EMBO REPORTS

The MUC1 mucin protects againstHelicobacter pyloripathogenesis in mice by regulation of the NLRP3 inflammasome

(2015) Garrett Z Ng et al.   GUT

Pseudomonas aeruginosa stimulates tyrosine phosphorylation of and TLR5 association with the MUC1 cytoplasmic tail through EGFR activation

(2015) Kosuke Kato et al.   INFLAMMATION RESEARCH

Intestinal Fucose as a Mediator of Host–Microbe Symbiosis

(2015) Joseph M. Pickard et al.   JOURNAL OF IMMUNOLOGY

Suppression of Toll-like receptor-mediated innate immune responses at the ocular surface by the membrane-associated mucins MUC1 and MUC16

(2015) B B Menon et al.   Mucosal Immunology

Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer

(2015) S Das et al.   ONCOGENE

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells

(2015) Srustidhar Das et al.   Oncotarget

Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifying Golgi/post-Golgi compartments

(2015) Srustidhar Das et al.   Scientific Reports

MUC1 Regulates Epithelial Inflammation and Apoptosis by PolyI:C through Inhibition of Toll/IL-1 Receptor-Domain–Containing Adapter-Inducing IFN-β (TRIF) Recruitment to Toll-like Receptor 3

(2014) Kosuke Kato et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

MUC16 mucin (CA125) attenuates TRAIL-induced apoptosis by decreasing TRAIL receptor R2 expression and increasing c-FLIP expression

(2014) Isabelle Matte et al.   BMC CANCER

Importance of altered glycoprotein-bound N- and O-glycans for epithelial-to-mesenchymal transition and adhesion of cancer cells

(2014) Tobias Lange et al.   CARBOHYDRATE RESEARCH

Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1

(2014) Qicheng Zhao et al.   CARCINOGENESIS

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

(2014) Thaher Pelaseyed et al.   IMMUNOLOGICAL REVIEWS

GastricDe NovoMuc13 Expression and Spasmolytic Polypeptide-Expressing Metaplasia during Helicobacter heilmannii Infection

(2014) Cheng Liu et al.   INFECTION AND IMMUNITY

Three-dimensional intestinal villi epithelium enhances protection of human intestinal cells from bacterial infection by inducing mucin expression

(2014) Si Hyun Kim et al.   Integrative Biology

Refined Candidate Region for F4ab/ac Enterotoxigenic Escherichia coli Susceptibility Situated Proximal to MUC13 in Pigs

(2014) Tiphanie Goetstouwers et al.   PLoS One

Specific MUC1 Splice Variants Are Correlated With Tumor Progression in Esophageal Cancer

(2014) Kolsoum Rezaie Kahkhaie et al.   WORLD JOURNAL OF SURGERY

MUC1 extracellular domain confers resistance of epithelial cancer cells to anoikis

(2014) Q Zhao et al.   Cell Death & Disease

MUC1 regulates cyclin D1 gene expression through p120 catenin and β-catenin

(2014) X Liu et al.   Oncogenesis

Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes

(2013) Thaher Pelaseyed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell-protective device

(2013) Thaher Pelaseyed et al.   FEBS Journal

Enterotoxigenic Escherichia coli Secretes a Highly Conserved Mucin-Degrading Metalloprotease To Effectively Engage Intestinal Epithelial Cells

(2013) Qingwei Luo et al.   INFECTION AND IMMUNITY

Functions and regulation of MUC13 mucin in colon cancer cells

(2013) Brij K. Gupta et al.   JOURNAL OF GASTROENTEROLOGY

The mucin-type glycosylating enzyme polypeptide N-acetylgalactosaminyltransferase 14 promotes the migration of ovarian cancer by modifying mucin 13

(2013) RANRAN WANG et al.   ONCOLOGY REPORTS

Gene Silencing of Porcine MUC13 and ITGB5: Candidate Genes towards Escherichia coli F4ac Adhesion

(2013) Chuanli Zhou et al.   PLoS One

Mucus Properties and Goblet Cell Quantification in Mouse, Rat and Human Ileal Peyer's Patches

(2013) Anna Ermund et al.   PLoS One

Mesothelin Binding to CA125/MUC16 Promotes Pancreatic Cancer Cell Motility and Invasion via MMP-7 Activation

(2013) Shih-Hsun Chen et al.   Scientific Reports

Prevention of lung injury by Muc1 mucin in a mouse model of repetitive Pseudomonas aeruginosa infection

(2012) Tsuyoshi Umehara et al.   INFLAMMATION RESEARCH

Increased Expression and Aberrant Localization of Mucin 13 in Metastatic Colon Cancer

(2012) Brij K. Gupta et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Membrane-Tethered MUC1 Mucin Is Phosphorylated by Epidermal Growth Factor Receptor in Airway Epithelial Cells and Associates with TLR5 To Inhibit Recruitment of MyD88

(2012) K. Kato et al.   JOURNAL OF IMMUNOLOGY

MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli

(2012) Y H Sheng et al.   Mucosal Immunology

Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways

(2012) M Kesimer et al.   Mucosal Immunology

Susceptibility towards Enterotoxigenic Escherichia coli F4ac Diarrhea Is Governed by the MUC13 Gene in Pigs

(2012) Jun Ren et al.   PLoS One

Secreted Aspartic Protease Cleavage of Candida albicans Msb2 Activates Cek1 MAPK Signaling Affecting Biofilm Formation and Oropharyngeal Candidiasis

(2012) Sumant Puri et al.   PLoS One

Antiinflammatory Role of MUC1 Mucin during Infection with NontypeableHaemophilus influenzae

(2011) Yoshiyuki Kyo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

MUC1/A and MUC1/B splice variants differentially regulate inflammatory cytokine expression

(2011) Yoannis Imbert-Fernandez et al.   EXPERIMENTAL EYE RESEARCH

The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis

(2011) Y. H. Sheng et al.   GUT

MUC1 Protein Expression in Tumor Cells Regulates Transcription of Proinflammatory Cytokines by Forming a Complex with Nuclear Factor-κB p65 and Binding to Cytokine Promoters

(2011) Sandra Cascio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CFTR anion channel modulates expression of human transmembrane mucin MUC3 through the PDZ protein GOPC

(2011) T. Pelaseyed et al.   JOURNAL OF CELL SCIENCE

Overexpression of MUC1 Enhances Proangiogenic Activity of Non-Small-Cell Lung Cancer Cells Through Activation of Akt and Extracellular Signal-regulated Kinase Pathways

(2011) Mengying Yao et al.   LUNG

Mucin 13: Structure, Function, and Potential Roles in Cancer Pathogenesis

(2011) D. M. Maher et al.   MOLECULAR CANCER RESEARCH

Mucin 1 enhances the tumor angiogenic response by activation of the AKT signaling pathway

(2011) J K Woo et al.   ONCOGENE

MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells

(2011) I Lakshmanan et al.   ONCOGENE

DNA methylation and histone H3-K9 modifications contribute to MUC17 expression

(2010) Sho Kitamoto et al.   GLYCOBIOLOGY

Two Atypical Enteropathogenic Escherichia coli Strains Induce the Production of Secreted and Membrane-Bound Mucins To Benefit Their Own Growth at the Apical Surface of Human Mucin-Secreting Intestinal HT29-MTX Cells

(2010) M. A. M. Vieira et al.   INFECTION AND IMMUNITY

Muc1 Cell Surface Mucin Attenuates Epithelial Inflammation in Response to a Common Mucosal Pathogen

(2010) Wei Guang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MUC1-C Oncoprotein Functions as a Direct Activator of the Nuclear Factor- B p65 Transcription Factor

(2009) R. Ahmad et al.   CANCER RESEARCH

Circulating Galectin-3 Promotes Metastasis by Modifying MUC1 Localization on Cancer Cell Surface

(2009) Q. Zhao et al.   CANCER RESEARCH

TGFβ regulation of membrane mucin Muc4 via proteosome degradation

(2009) Wieslawa M. Lomako et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Deletion of the Mucin-Like Molecule Muc1 Enhances Dendritic Cell Activation in Response to Toll-Like Receptor Ligands

(2009) Marc A. Williams et al.   Journal of Innate Immunity

MUC1 Limits Helicobacter pylori Infection both by Steric Hindrance and by Acting as a Releasable Decoy

(2009) Sara K. Lindén et al.   PLoS Pathogens

Barrier properties of mucus

(2008) Richard A. Cone   ADVANCED DRUG DELIVERY REVIEWS

The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine

(2008) Emily K. Malmberg et al.   BIOCHEMICAL JOURNAL

Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases

(2008) Audrey Vincent et al.   FASEB JOURNAL

Phosphorylation of MUC1 by Met Modulates Interaction with p53 and MMP1 Expression

(2008) Pankaj K. Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast

(2008) Nadia Vadaie et al.   JOURNAL OF CELL BIOLOGY

Mucin Dynamics in Intestinal Bacterial Infection

(2008) Sara K. Lindén et al.   PLoS One

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MUC1 Mucin Is a Negative Regulator of Toll-Like Receptor Signaling

(2007) Keiko Ueno et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY