OTUD1 Activates Caspase‐Independent and Caspase‐Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation

MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer

(2019) Xiaowei Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JOSD1 inhibits mitochondrial apoptotic signalling to drive acquired chemoresistance in gynaecological cancer by stabilizing MCL1

(2019) Xiaowei Wu et al.   CELL DEATH AND DIFFERENTIATION

AIF-regulated oxidative phosphorylation supports lung cancer development

(2019) Shuan Rao et al.   CELL RESEARCH

From Inhibition to Degradation: Targeting the Anti-apoptotic Protein Myeloid Cell Leukemia 1 (MCL1)

(2019) James William Papatzimas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

(2019) Xin Wu et al.   Nature Communications

ARID1A ablation leads to multiple drug resistance in ovarian cancer via transcriptional activation of MRP2

(2018) Qingyu Luo et al.   CANCER LETTERS

Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD

(2018) Silvia Escudero et al.   MOLECULAR CELL

SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity

(2018) Fan Yao et al.   Nature Communications

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling

(2017) Martin A. Michel et al.   MOLECULAR CELL

Deubiquitylating enzymes and drug discovery: emerging opportunities

(2017) Jeanine A. Harrigan et al.   NATURE REVIEWS DRUG DISCOVERY

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

(2017) Zhengkui Zhang et al.   Nature Communications

Which factors are associated with extremely short-term survival after surgery in patients with esophageal squamous cell carcinoma?

(2016) Jingeng Liu et al.   Asia-Pacific Journal of Clinical Oncology

Cancer statistics in China, 2015

(2016) Wanqing Chen et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Regulation of pluripotency and differentiation by deubiquitinating enzymes

(2016) B Suresh et al.   CELL DEATH AND DIFFERENTIATION

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

(2016) András Kotschy et al.   NATURE

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

(2016) Y. Wang et al.   SCIENCE

Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia

(2015) R. Pan et al.   BLOOD

Recent Advances From Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma

(2015) Shinya Ohashi et al.   GASTROENTEROLOGY

Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis

(2015) Emilie Hangen et al.   MOLECULAR CELL

Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation

(2014) Matthew Locke et al.   BIOCHEMICAL JOURNAL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Oesophageal cancer—an overview

(2013) Michael Schweigert et al.   Nature Reviews Gastroenterology & Hepatology

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Host Immune Defense Peptide LL-37 Activates Caspase-Independent Apoptosis and Suppresses Colon Cancer

(2012) S. X. Ren et al.   CANCER RESEARCH

Nondegradative Ubiquitination of Apoptosis Inducing Factor (AIF) by X-Linked Inhibitor of Apoptosis at a Residue Critical for AIF-Mediated Chromatin Degradation

(2011) Eric M. Lewis et al.   BIOCHEMISTRY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme

(2011) K H Oh et al.   CELL DEATH AND DIFFERENTIATION

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody

(2010) Marissa L. Matsumoto et al.   MOLECULAR CELL

Mitochondrial μ-calpain is not involved in the processing of apoptosis-inducing factor

(2009) Aashish Joshi et al.   EXPERIMENTAL NEUROLOGY

Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos)

(2009) Yingfei Wang et al.   JOURNAL OF NEUROCHEMISTRY

Control of AMPK-related kinases by USP9X and atypical Lys29/Lys33-linked polyubiquitin chains

(2008) Abdallah K. Al-Hakim et al.   BIOCHEMICAL JOURNAL

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

(2008) S Landshamer et al.   CELL DEATH AND DIFFERENTIATION