Precision Surface Microtopography Regulates Cell Fate via Changes to Actomyosin Contractility and Nuclear Architecture

Actomyosin, vimentin and LINC complex pull on osteosarcoma nuclei to deform on micropillar topography

(2020) Nayana Tusamda Wakhloo et al.   BIOMATERIALS

Dysfunctional Mechanotransduction through the YAP/TAZ/Hippo Pathway as a Feature of Chronic Disease

(2020) Mathias Cobbaut et al.   Cells

Synergistic Effect of Cell-Derived Extracellular Matrices and Topography on Osteogenesis of Mesenchymal Stem Cells

(2020) Liangliang Yang et al.   ACS Applied Materials & Interfaces

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

(2020) Michele M. Nava et al.   CELL

The Roles of Human DNA Methyltransferases and Their Isoforms in Shaping the Epigenome

(2019) Hemant Gujar et al.   Genes

Micropatterned fibrous scaffolds for biomedical application

(2019) Madhumita Patel et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease

(2019) Melanie Maurer et al.   Annual Review of Biomedical Engineering

Nanoneedle-Mediated Stimulation of Cell Mechanotransduction Machinery

(2019) Catherine S. Hansel et al.   ACS Nano

Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis

(2019) Yekaterina A Miroshnikova et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Substrate mechanics controls adipogenesis through YAP phosphorylation by dictating cell spreading

(2019) Jorge Oliver-De La Cruz et al.   BIOMATERIALS

Amplification of Nuclear Deformation of Breast Cancer Cells by Seeding on Micropatterned Surfaces to Better Distinguish Their Malignancies

(2019) Ezgi Antmen et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Chromatin’s physical properties shape the nucleus and its functions

(2019) Andrew D Stephens et al.   CURRENT OPINION IN CELL BIOLOGY

Dynamic adaptation of mesenchymal stem cell physiology upon exposure to surface micropatterns

(2019) Nick R. M. Beijer et al.   Scientific Reports

Mechanotransduction in cardiovascular morphogenesis and tissue engineering

(2019) Anne-Laure Duchemin et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Customizable, engineered substrates for rapid screening of cellular cues

(2019) Eline Huethorst et al.   Biofabrication

A Micropatterning Strategy to Study Nuclear Mechanotransduction in Cells

(2019) Markville Bautista et al.   Micromachines

Cell Adhesion, Morphology, and Metabolism Variation via Acoustic Exposure within Microfluidic Cell Handling Systems

(2019) Citsabehsan Devendran et al.   Advanced Science

YAP as a key regulator of adipo-osteogenic differentiation in human MSCs

(2019) Chanchao Lorthongpanich et al.   Stem Cell Research & Therapy

Tensile Forces and Mechanotransduction at Cell–Cell Junctions

(2018) Guillaume Charras et al.   CURRENT BIOLOGY

Effects of Matrix Stiffness on the Morphology, Adhesion, Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells

(2018) Meiyu Sun et al.   International Journal of Medical Sciences

Cell-geometry-dependent changes in plasma membrane order direct stem cell signalling and fate

(2018) Thomas C. von Erlach et al.   NATURE MATERIALS

Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling

(2018) Jessica E. Frith et al.   Nature Communications

Designing stem cell niches for differentiation and self-renewal

(2018) Hannah Donnelly et al.   Journal of the Royal Society Interface

The Molecular Revolution in Cutaneous Biology: Chromosomal Territories, Higher-Order Chromatin Remodeling, and the Control of Gene Expression in Keratinocytes

(2017) Vladimir A. Botchkarev   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Effect of the Microenvironment on Mesenchymal Stem Cell Paracrine Signaling: Opportunities to Engineer the Therapeutic Effect

(2017) Gina D. Kusuma et al.   STEM CELLS AND DEVELOPMENT

E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning

(2017) Matthias Rübsam et al.   Nature Communications

Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology

(2017) Jeong-Ki Kim et al.   Nature Communications

Actomyosin and vimentin cytoskeletal networks regulate nuclear shape, mechanics and chromatin organization

(2017) Michael C. Keeling et al.   Scientific Reports

High-aspect-ratio nanoimprint process chains

(2017) Víctor J. Cadarso et al.   Microsystems & Nanoengineering

Nuclear morphologies: their diversity and functional relevance

(2016) Benjamin M. Skinner et al.   CHROMOSOMA

Regulatory Roles of Fluctuation-Driven Mechanotransduction in Cell Function

(2016) Béla Suki et al.   PHYSIOLOGY

Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity

(2016) Su-Jin Heo et al.   eLife

Topographical cues regulate the crosstalk between MSCs and macrophages

(2015) Gema Vallés et al.   BIOMATERIALS

Characterization of Dnmt1 Binding and DNA Methylation on Nucleosomes and Nucleosomal Arrays

(2015) Anna Schrader et al.   PLoS One

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

Mechanical regulation of mesenchymal stem cell differentiation

(2014) Andrew J. Steward et al.   JOURNAL OF ANATOMY

Tensegrity, cellular biophysics, and the mechanics of living systems

(2014) Donald E Ingber et al.   REPORTS ON PROGRESS IN PHYSICS

The Spatial Organization of the Human Genome

(2013) Wendy A. Bickmore   Annual Review of Genomics and Human Genetics

Effect of RGD nanospacing on differentiation of stem cells

(2013) Xuan Wang et al.   BIOMATERIALS

The regulation of dynamic mechanical coupling between actin cytoskeleton and nucleus by matrix geometry

(2013) Qingsen Li et al.   BIOMATERIALS

Cell force measurements in 3D microfabricated environments based on compliant cantilevers

(2013) Mattia Marelli et al.   LAB ON A CHIP

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

The role of microtopography in cellular mechanotransduction

(2012) Laura E. McNamara et al.   BIOMATERIALS

Decoupling Substrate Stiffness, Spread Area, and Micropost Density: A Close Spatial Relationship between Traction Forces and Focal Adhesions

(2012) Sangyoon J. Han et al.   BIOPHYSICAL JOURNAL

Lateral spacing of adhesion peptides influences human mesenchymal stem cell behaviour

(2012) J. E. Frith et al.   JOURNAL OF CELL SCIENCE

Substrate elasticity controls cell proliferation, surface marker expression and motile phenotype in amniotic fluid-derived stem cells

(2012) Aleksander Skardal et al.   Journal of the Mechanical Behavior of Biomedical Materials

Biomimetic microtopography to enhance osteogenesis in vitro

(2011) Andrew Wilkinson et al.   Acta Biomaterialia

Topographic Modulation of the Orientation and Shape of Cell Nuclei and Their Influence on the Measured Elastic Modulus of Epithelial Cells

(2011) Clayton T. McKee et al.   BIOPHYSICAL JOURNAL

Proliferation of Mesenchymal Stem Cell on Chitosan Films Associated with Convex Micro-topography

(2011) Julin Yang et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Role of mechanical factors in fate decisions of stem cells

(2011) Dong Li et al.   Regenerative Medicine

Mechanical control of tissue and organ development

(2010) T. Mammoto et al.   DEVELOPMENT

Mechanical characteristics of an Ormocomp® biocompatible hybrid photopolymer

(2010) Charalampos Schizas et al.   Journal of the Mechanical Behavior of Biomedical Materials

Effects of size on the mechanical response of metallic glasses investigated through in situ TEM bending and compression experiments

(2009) C.Q. Chen et al.   ACTA MATERIALIA

A mechanosensitive transcriptional mechanism that controls angiogenesis

(2009) Akiko Mammoto et al.   NATURE

Tensegrity-based mechanosensing from macro to micro

(2008) Donald E. Ingber   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY