Article
Multidisciplinary Sciences
Donghyun Kang, Jeeyeon Lee, Jisu Jung, Bradley A. Carlson, Moon Jong Chang, Chong Bum Chang, Seung-Baik Kang, Byung Cheon Lee, Vadim N. Gladyshev, Dolph L. Hatfield, Byeong Jae Lee, Jin-Hong Kim
Summary: Osteoarthritis is caused by the accumulation of oxidative stress. This study reveals that dysregulation of the selenium metabolic pathway disrupts redox homeostasis in chondrocytes, leading to the development of osteoarthritis. The downregulation of SEPHS1 impairs the synthesis of oxidoreductase selenoproteins, increases reactive oxygen species levels, and induces chondrocyte senescence.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Erik Schoenmakers, Krishna Chatterjee
Summary: Selenium, an essential trace element for human health, is incorporated into selenoproteins through the amino acid selenocysteine. Mutations in genes essential for selenocysteine incorporation pathway can result in systemic selenoprotein deficiency, leading to a complex disorder affecting specific tissues and impairing antioxidant and stress defense mechanisms. Antioxidant therapy shows promise in ameliorating oxidative damage, but the long-term benefits are still unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Julian Hackler, Kamil Demircan, Thilo Samson Chillon, Qian Sun, Nino Geisler, Michael Schupp, Kostja Renko, Lutz Schomburg
Summary: Selenium is an essential trace element that affects the expression of SELENOP. A drug screening was performed to identify inhibitors of SELENOP expression, and resveratrol was found to be the most potent inhibitor. The results suggest that resveratrol may increase liver Se levels and selenoprotein expression.
Review
Biochemistry & Molecular Biology
Jessica L. Nicholson, Pamela Toh, Naghum Alfulaij, Marla J. Berry, Daniel J. Torres
Summary: It has been 50 years since the discovery of the first selenoprotein, and our understanding of the importance of selenium has greatly increased. We now know that the brain relies on selenium for proper functioning, and a lack of certain selenoproteins can lead to neurodegeneration. Additionally, selenoprotein-mediated redox balance has been found to affect neuronal activity.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Vladimir V. Rogachev, Michael V. Goltyaev, Elena G. Varlamova, Egor A. Turovsky
Summary: Currently, there is active development in the field of selenobiology, focusing on the role of selenium and its compounds in regulating vital cellular processes. The functions of selenium nanoparticles have gained popularity, while the study of selenoproteins, especially SELENOM, remains underexplored. This research investigates the molecular mechanisms of SELENOM's cytotoxic effect on human glioblastoma cells, revealing its involvement in apoptosis, endoplasmic reticulum stress, and the regulation of calcium homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Chi Ma, Verena Martinez-Rodriguez, Peter R. Hoffmann
Summary: The selenoprotein family comprises 25 members, with SELENOI being a unique member functioning as an ethanolamine phosphotransferase. SELENOI plays a crucial role in the synthesis of cellular membrane constituents, impacting metabolic reprogramming and proliferative capacity in T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Theresa Wolfram, Leonie M. Weidenbach, Johanna Adolf, Maria Schwarz, Patrick Schaedel, Andre Gollowitzer, Oliver Werz, Andreas Koeberle, Anna P. Kipp, Solveigh C. Koeberle
Summary: The study shows that selenium can regulate the redox signaling in macrophages, affecting the expression of selenoproteins and the production of lipid mediators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lionel Tarrago, Alaattin Kaya, Hwa-Young Kim, Bruno Manta, Byung-Cheon Lee, Vadim N. Gladyshev
Summary: Methionine sulfoxide reductases (MSR) are enzymes that reduce methionine sulfoxide (MetO) back to methionine. MSRB1, a selenoprotein found in mammals, uses selenocysteine as a catalytic residue. It plays a crucial role in oxidative stress protection, neuronal cell maintenance, cognition, cancer cell proliferation, and immune response.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Medicine, Research & Experimental
Yinghua Li, Danyang Chen, Jingyao Su, Mingkai Chen, Tianfeng Chen, Wei Jia, Bing Zhu
Summary: This study constructed a selenium-containing metal complex drug delivery system Ru(biim)(PhenSe)2 (RuSe) and investigated its anti-influenza virus efficacy and potential antiviral mechanism. The results showed that RuSe enhanced the expression levels of selenium proteins GPx1 and TrxR1 by regulating selenium metabolism, thereby inhibiting viral replication and assembly and regulating virus-mediated mitochondria-related apoptosis. Animal experiments confirmed that RuSe reduced lung tissue inflammation, inhibited lung tissue cell apoptosis, and improved the survival state of mice. RuSe also effectively improved the low immune response and alleviated lung fibrosis in Se-deficient mice.
Article
Biochemistry & Molecular Biology
Ying-Chen Huang, Gerald F. Combs Jr, Tung-Lung Wu, Huawei Zeng, Wen-Hsing Cheng
Summary: Optimal selenium status is important for overall health, and it can be influenced by various factors such as food intake pattern, age, sex, and health status. Insufficient intake of selenium can reduce the expression of selenium-containing proteins, while both insufficient and excessive intakes may increase the risk of type 2 diabetes mellitus. Understanding the relationship between selenium status and diabetes risk can inform the establishment of safe and adequate selenium intake.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Liangliang Zhang, Huan Xia, Kaide Xia, Xianmei Liu, Xin Zhang, Jie Dai, Zhu Zeng, Yi Jia
Summary: The study revealed that selenium can influence the immune function of mouse dendritic cells through multiple pathways, including regulating migration, antigen uptake, and lymphocyte reaction.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Didac Santesmasses, Vadim N. Gladyshev
Summary: Through analysis of the co-essentiality network, this study identified functional partners of selenoproteins and Sec machinery proteins. The key role of selenium is to support the functions of GPX4 and TXNRD1, with further functional links to PRDX6 and SCD.
Article
Biochemistry & Molecular Biology
Yujiao He, Lin Peng, Xiaochun Zhao, Xue Fan, Xinyu Tang, Guangliang Shi, Shu Li
Summary: Selenium deficiency can lead to intestinal damage and induce inflammation. This study found that selenium deficiency reduces the levels of antioxidant selenoproteins in the chicken intestine, causing oxidative stress and compromising the integrity of the intestinal barrier.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Amra Jujic, John Molvin, Lutz Schomburg, Oliver Hartmann, Andreas Bergmann, Olle Melander, Martin Magnusson
Summary: A recent study found that high selenium levels are associated with reduced mortality and incidence of heart failure (HF), but only in non-smokers. This study aimed to investigate whether selenoprotein P (SELENOP) is associated with incident HF. The results showed that low SELENOP levels are associated with a higher risk of incident HF in the general population.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Qianru Chi, Qing Zhang, Yiming Lu, Yiming Zhang, Shiwen Xu, Shu Li
Summary: Selenium deficiency induces arteritis by reducing SelS levels and promotes disease progression by regulating neutrophil recruitment and NET formation. The formation of NETs in arteritis is dependent on ROS bursts and the PPAR pathway. Silencing SelS exacerbates arteritis through its effects on NET formation.
Article
Environmental Sciences
Qunxiang Shi, Xi Jin, Ruifeng Fan, Mengyuan Xing, Jinming Guo, Ziwei Zhang, Junmin Zhang, Shiwen Xu
Article
Biochemistry & Molecular Biology
Houjuan Xing, Shufang Zheng, Ziwei Zhang, Fating Zhu, Hua Xue, Shiwen Xu
BIOLOGICAL TRACE ELEMENT RESEARCH
(2019)
Article
Cell Biology
Qiaojian Zhang, Shengchen Wang, Shufang Zheng, Ziwei Zhang, Shiwen Xu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Environmental Sciences
Hongyuan Jing, Xuejiao Gao, Liqiang Xu, Hongjin Lin, Ziwei Zhang
Article
Engineering, Environmental
Menghao Chen, Xiaojing Li, Qunxiang Shi, Ziwei Zhang, Shiwen Xu
JOURNAL OF HAZARDOUS MATERIALS
(2019)
Article
Biochemistry & Molecular Biology
Jianwen Xu, Yafan Gong, Yue Sun, Jingzeng Cai, Qi Liu, Jun Bao, Jie Yang, Ziwei Zhang
BIOLOGICAL TRACE ELEMENT RESEARCH
(2020)
Article
Marine & Freshwater Biology
Qi Liu, Jie Yang, Yafan Gong, Jingzeng Cai, Ziwei Zhang
AQUATIC TOXICOLOGY
(2019)
Article
Environmental Sciences
Yuan Zhang, Guangliang Shi, Jingzeng Cai, Jie Yang, Yingying Zheng, Dahai Yu, Qi Liu, Yafan Gong, Ziwei Zhang
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2019)
Article
Engineering, Environmental
Yingying Zheng, Guangliang Shi, Jingzeng Cai, Jie Yang, Yuan Zhang, Yafan Gong, Qi Liu, Dahai Yu, Ziwei Zhang
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Environmental Sciences
Jingzeng Cai, Guangliang Shi, Yuan Zhang, Yingying Zheng, Jie Yang, Qi Liu, Yafan Gong, Dahai Yu, Ziwei Zhang
ENVIRONMENTAL POLLUTION
(2019)
Article
Fisheries
Shuting Wang, Yirong Cao, Shengchen Wang, Jingzeng Cai, Ziwei Zhang
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Engineering, Environmental
Shufang Zheng, Shengchen Wang, Qiaojian Zhang, Ziwei Zhang, Shiwen Xu
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Medicine, Research & Experimental
Jie Yang, Yafan Gong, Jingzeng Cai, Qi Liu, Ziwei Zhang
MOLECULAR THERAPY-NUCLEIC ACIDS
(2019)
Article
Agriculture, Dairy & Animal Science
Haoyue Guan, Wenxue Ma, Qiong Wu, Jingzeng Cai, Ziwei Zhang
Summary: This study constructed an in vitro model of zearalenone toxicity in porcine small intestinal epithelial cells and conducted various tests. The results showed that zearalenone can cause oxidative stress, inflammatory response, and apoptosis in porcine small intestinal cells, causing damage to the intestinal tissues. The study of zearalenone's effects on the intestinal tract of swine is of great significance for the prevention and treatment of zearalenone infection in swine.
Article
Biochemistry & Molecular Biology
Jingzeng Cai, Jie Yang, Qi Liu, Yafan Gong, Yuan Zhang, Ziwei Zhang