Article
Biochemistry & Molecular Biology
Sonia Podvin, Zhenze Jiang, Ben Boyarko, Leigh-Ana Rossitto, Anthony O'Donoghue, Robert A. Rissman, Vivian Hook
Summary: This study evaluated neuropeptide signatures and tau peptide signatures in Alzheimer's disease (AD) brains compared to age-matched controls. The results showed distinct profiles of neuropeptides and unique tau peptides in AD, indicating differences in proteolytic processing. These findings suggest that the dysregulation of neuropeptides and tau peptides may contribute to the cognitive deficits observed in AD.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Jessica Panes-Fernandeza, Pamela A. Godoy, Javiera Gavilan, Oscar Ramirez-Molina, Carlos Felipe Burgos, Ana Marileo, Oscar Flores-Nunez, Patricio A. Castro, Gustavo Moraga-Cid, Gonzalo E. Yevenes, Carola Munoz-Montesino, Jorge Fuentealba
Summary: Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by cognitive impairment in the elderly. Transglutaminase type 2 (TG2) has been found to promote aggregation of the amyloid beta peptide (Aβ) and contribute to cellular damage and synaptic failure. This study demonstrates that TG2 enhances calcium overload and disrupts mitochondrial-endoplasmic reticulum contacts, leading to neuronal damage and dysfunctional synapses. Inhibition of TG2 reverses these effects, highlighting the potential of TG2 inhibitors as a therapeutic strategy for AD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Yiran Sun, Chenchen Yan, Libo He, Shixie Xiang, Pan Wang, Zhonghua Li, Yuanzhao Chen, Jie Zhao, Ye Yuan, Wang Wang, Xiaowei Zhang, Pan Su, Yunfang Su, Jinlian Ma, Jiangyan Xu, Quekun Peng, Huifen Ma, Zhishen Xie, Zhenqiang Zhang
Summary: Alzheimer's disease (AD), a chronic and progressive neurodegenerative disease, poses a serious threat to the health of the elderly. The microscopic features of the AD brain are amyloid plaques and neurofibrillary tangles. Despite extensive research, there are still no effective drugs to halt the progression of AD. Ferroptosis, a type of programmed cell death, has been shown to promote the development of AD, and inhibiting neuronal ferroptosis can improve cognitive impairment. Calcium (Ca2+) dyshomeostasis has been found to be closely related to AD pathology, driving ferroptosis through various pathways. This paper reviews the roles of ferroptosis and Ca2+ in AD pathology and suggests that targeting the homeostasis of Ca2+ to restrain ferroptosis may be an innovative approach for AD treatment.
AGEING RESEARCH REVIEWS
(2023)
Article
Neurosciences
Benjamin R. Troutwine, Taylor A. Strope, Edziu Franczak, Colton R. Lysaker, Laylan Hamid, Clayton Mansel, Julia A. Stopperan, Cynthia M. Gouvion, Mohammad Haeri, Russell H. Swerdlow, Heather M. Wilkins
Summary: The study found that Alzheimer's disease (AD) patients have mitochondrial dysfunction, specifically reduced brain cytochrome oxidase (COX) function and complex II Vmax. APOE epsilon 4 carriers also have deficits in COX, complex II, and III. These results suggest a dysregulated relationship between brain mitochondrial function and A beta pathology in AD.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Multidisciplinary Sciences
Naohiro Kon, Hsin-tzu Wang, Yoshiaki S. Kato, Kyouhei Uemoto, Naohiro Kawamoto, Koji Kawasaki, Ryosuke Enoki, Gen Kurosawa, Tatsuto Nakane, Yasunori Sugiyama, Hideaki Tagashira, Motomu Endo, Hideo Iwasaki, Takahiro Iwamoto, Kazuhiko Kume, Yoshitaka Fukada
Summary: Temperature compensation of circadian rhythms is achieved through NCX-mediated Ca2+ signaling, which plays essential roles in maintaining temperature-compensated oscillations.
Review
Pharmacology & Pharmacy
L. van Olst, L. Coenen, J. M. Nieuwland, C. Rodriguez-Mogeda, N. M. de Wit, A. Kamermans, J. Middeldorp, H. E. de Vries
Summary: Alzheimer's disease is the most common form of dementia, and currently there are only medications that can improve symptoms but not cure the disease. Recent studies have shown that T cells play an important role in the pathogenesis of Alzheimer's disease, and targeting T cells can combat the pathology and cognitive decline.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Biology
Chuyuan Wang, Ying Wei, Jiaguang Li, Xiang Li, Yue Liu, Qian Hu, Yuefeng Wang
Summary: This study proposed an asymmetry enhanced attention network for Alzheimer's disease diagnosis, effectively combining brain anatomical asymmetry characteristics to enhance classification accuracy. The method achieved performance improvements on two databases and provides valuable reference for other neurological diseases.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Panagiota Pagoni, Roxanna S. Korologou-Linden, Laura D. Howe, George Davey Smith, Yoav Ben-Shlomo, Evie Stergiakouli, Emma L. Anderson
Summary: This study suggests a causal role of cytokines in the pathogenesis of Alzheimer's disease and fluid intelligence.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Solveig Tiepolt, Philipp M. Meyer, Marianne Patt, Winnie Deuther-Conrad, Swen Hesse, Henryk Barthel, Osama Sabri
Summary: This review summarizes the current knowledge on positron emission tomography (PET) imaging of cholinergic neurotransmission in neurodegenerative diseases. Research suggests that PET imaging of cholinergic receptors, transporters, enzymes, and acetylcholinesterase can provide valuable insights into the diagnosis, monitoring, and treatment of neurodegenerative diseases.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Nanoscience & Nanotechnology
Feng Guo, Qingman Li, Xiaolin Zhang, Yiheng Liu, Jie Jiang, Shuanghuai Cheng, Si Yu, Xingfang Zhang, Fangfang Liu, Yiying Li, Gregory Rose, Haiying Zhang
Summary: Currently, there are 50 million AD patients worldwide, and the exact cause of the disease is still unknown. However, amyloid plaques and neurofibrillary tangles in the brain are regarded as the typical features of AD. Although current drug treatments can slow down the progression of the disease and improve the patients' quality of life, they are not highly effective and cannot cure the disease. The blood-brain barrier (BBB) is a major obstacle in developing and delivering more effective drug therapies, but nanotechnology, specifically carbon dots (CDs), shows promise in overcoming this obstacle.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Behavioral Sciences
Raghuram Kandimalla, Mohd Saeed, Neetu Tyagi, Ramesh C. Gupta, Farrukh Aqil
Summary: Alzheimer's disease (AD) is a widely studied neurological disorder that affects millions of individuals worldwide and is caused by misfolded proteins in the brain, particularly amyloid-beta and tau. While therapeutic interventions and nanotechnological advancements can help manage AD symptoms, a cure for this disease has yet to be found. Exosomes, which can originate from various cell and tissue types, have a dual role in the progression and treatment of AD. They can be manipulated to deliver therapeutic cargos, both small molecules and macromolecules, to the brain. This review focuses on the roles of exosomes in the pathology, diagnosis, and treatment of AD, as well as their potential as drug carriers for AD treatment.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Food Science & Technology
Abhinav Anand, Navneet Khurana, Rajesh Kumar, Neha Sharma
Summary: This paper reviews the application of probiotics in the treatment of Alzheimer's disease. Probiotics have anti-inflammatory and immunomodulatory effects, maintain the integrity of the intestinal epithelium and the blood-brain barrier, and also have antioxidant and cognition enhancing capabilities, making them a promising therapeutic approach for AD.
Article
Neurosciences
Juan M. Morales-Ropero, Sandra Arroyo-Urea, Veronika E. Neubrand, David Martin-Oliva, Jose L. Marin-Teva, Miguel A. Cuadros, Peter Vangheluwe, Julio Navascues, Ana M. Mata, M. Rosario Sepulveda
Summary: The upregulation of SERCA2b in activated microglia of Alzheimer's disease brain suggests its crucial role in regulating microglial functions, affecting migration and phagocytosis in opposite manners. This study provides compelling evidence for SERCA2b as a major player in controlling cytosolic Ca2+ levels and influencing microglial behavior during activation. Targeting SERCA2b levels may be a potential therapeutic strategy for modulating microglial activity in neurodegenerative diseases.
Article
Chemistry, Multidisciplinary
Liron L. Israel, Anna Galstyan, Alysia Cox, Ekaterina S. Shatalova, Tao Sun, Mohammad-Harun Rashid, Zachary Grodzinski, Antonella Chiechi, Dieu-Trang Fuchs, Rameshwar Patil, Maya Koronyo-Hamaoui, Keith L. Black, Julia Y. Ljubimova, Eggehard Holler
Summary: The ability to cross the blood-brain barrier is crucial for targeted therapy of the central nervous system. In this study, six peptide vectors were used to enhance the permeation of the blood-brain barrier. These vectors exhibited specificity for different receptors and showed varying efficacies in different models. This research provides valuable insights into the role of nanoconjugates in treating central nervous system diseases.
Article
Clinical Neurology
Donghui Wang, Xiaoshuang Zhang, Hongwu Du
Summary: Alzheimer's disease is a central nervous system disease associated with intestinal microbes and inflammatory bowel disease. Patients with inflammatory bowel disease are at a higher risk of developing Alzheimer's disease.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Agriculture, Multidisciplinary
Zhong-Hao Zhang, Lei Wen, Qiu-Yan Wu, Chen Chen, Rui Zheng, Qiong Liu, Jia-Zuan Ni, Guo-Li Song
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Zhong-Hao Zhang, Qiu-Yan Wu, Chen Chen, Rui Zheng, Yao Chen, Jia-Zuan Ni, Guo-Li Song
Article
Optics
Hongji Liu, Ziwei Zhuang, Jiexing He, Shen Tong, Chen He, Xiangquan Deng, Guoli Song, Ping Qiu, Ke Wang
Article
Biochemistry & Molecular Biology
Rui Zheng, Zhong-Hao Zhang, Yu-Xi Zhao, Chen Chen, Shi-Zheng Jia, Xian-Chun Cao, Li-Ming Shen, Jia-Zuan Ni, Guo-Li Song
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Behavioral Sciences
Tengrui Shi, Yujie Yang, Zhonghao Zhang, Lei Zhang, Jianxi Song, Yongjing Ping, Xiubo Du, Guoli Song, Qiong Liu, Nan Li
NEUROBIOLOGY OF LEARNING AND MEMORY
(2019)
Article
Biochemistry & Molecular Biology
Zhong-Hao Zhang, Chen Chen, Shi-Zheng Jia, Xian-Chun Cao, Min Liu, Jing Tian, Peter R. Hoffmann, Hua-Xi Xu, Jia-Zuan Ni, Guo-Li Song
Summary: The study shows that the Se compound Se-Met can restore synaptic deficits in 3 x Tg-AD mice by modulating calcium influx mediated by synaptic and extrasynaptic NMDARs, indicating a potential functional interaction between SELENOK and NMDARs.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Neurosciences
Chen Chen, Di Xu, Zhong-Hao Zhang, Shi-Zheng Jia, Xian-Chun Cao, Yu-Bin Chen, Guo-Li Song, Man Shing Wong, Hung Wing Li
EXPERIMENTAL NEUROLOGY
(2020)
Article
Geriatrics & Gerontology
Chen Chen, Yao Chen, Zhong-Hao Zhang, Shi-Zheng Jia, Yu-Bin Chen, Shao-Ling Huang, Xin-Wen Xu, Guo-Li Song
Summary: Selenomethionine (Se-Met) improves mitochondrial function in Alzheimer's disease (AD) models by upregulating mitochondrial selenoprotein, promoting mitochondrial fusion or division, restoring mitochondrial membrane potential, enhancing mitochondrial energy metabolism, inhibiting intracellular ROS generation, and reducing apoptosis.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Correction
Geriatrics & Gerontology
Chen Chen, Yao Chen, Zhong-Hao Zhang, Shi-Zheng Jia, Yu-Bin Chen, Shao-Ling Huang, Xin-Wen Xu, Guo-Li Song
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Shi-Zheng Jia, Xin-Wen Xu, Zhong-Hao Zhang, Chen Chen, Yu-Bin Chen, Shao-Ling Huang, Qiong Liu, Peter R. Hoffmann, Guo-Li Song
Summary: Selenoprotein K plays a critical role in regulating intracellular calcium flux, degradation pathways, and response to stress in neurons. Knockout of SELENOK in neurons leads to increased apoptosis, activated cascade pathways, and decreased cognitive ability and increased anxiety in older mice.
Article
Biochemistry & Molecular Biology
Zhong-Hao Zhang, Xian-Chun Cao, Jia-Ying Peng, Shao-Ling Huang, Chen Chen, Shi-Zheng Jia, Jia-Zuan Ni, Guo-Li Song
Summary: This study demonstrates the therapeutic potential of combined supplementation of selenium and folic acid in Alzheimer's disease. The treatment regimen improves synaptic plasticity and cognitive ability by modulating brain lipid metabolism, potentially through antioxidant effects and promoting homocysteine metabolism.
Article
Chemistry, Medicinal
Yazhou Xie, Chen Chen, Shujing Lin, Xi Yu, Shuixian Ye, Xiaojie Chen, Na Ouyang, Wei Xiong, Chenyang Li, Chenshu Xu, Guoli Song, Haiqiang Wu
Summary: Alzheimer's disease (AD) is a multifactorial disease and one of the most common forms of dementia, with limited clinical efficacy of anti-AD drugs. Up-regulated glutaminyl cyclase (QC) and glycogen synthase kinase-3 beta (GSK-3 beta) play critical roles in AD. In this study, novel compounds were designed and synthesized as dual inhibitors targeting QC and GSK-3 beta, and showed significant inhibitory potency on both targets. In vivo studies showed that compound 8 attenuated cognitive deficits and reduced anxiety-like behavior in AD mice by inhibiting QC activity and decreasing GSK-3 beta levels. These compounds have potential as anti-AD agents targeting QC and GSK-3 beta.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Shujing Lin, Chen Chen, Pei Ouyang, Zhiyu Cai, Xibei Liu, Anwar Abdurahman, Jiaying Peng, Yu Li, Zhonghao Zhang, Guo-Li Song
Summary: Our study demonstrates that SELENOM knockout in mice results in decreased synaptic plasticity and memory impairment. Furthermore, SELENOM knockout leads to hyperglycemia and disrupts glucose metabolism, which is crucial for synapse formation and transmission in the brain. The inhibition of the brain insulin signaling pathway is identified as the underlying mechanism for the synaptic deficits and cognitive dysfunction observed in SELENOM knockout mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yinhui Li, Chen Chen, Di Xu, Chung-Yan Poon, See-Lok Ho, Rui Zheng, Qiong Liu, Guoli Song, Hung-Wing Li, Man Shing Wong
