Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

(2018) Michael S. Brown et al.   Annual Review of Biochemistry

A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans

(2018) Elizabeth A McAninch et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction

(2018) Sarah J. Peterson et al.   THYROID

DIO2 Thr92Ala Reduces Deiodinase-2 Activity and Serum-T3 Levels in Thyroid-Deficient Patients

(2017) Maria Grazia Castagna et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hypothyroidism

(2017) Layal Chaker et al.   LANCET

ER stress and the unfolded protein response in neurodegeneration

(2017) Claudio Hetz et al.   Nature Reviews Neurology

No Effect of the Thr92Ala Polymorphism of Deiodinase-2 on Thyroid Hormone Parameters, Health-Related Quality of Life, and Cognitive Functioning in a Large Population-Based Cohort Study

(2017) Hanneke J.C.M. Wouters et al.   THYROID

Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice

(2016) Barbara M. L. C. Bocco et al.   ENDOCRINOLOGY

The MID1 protein is a central player during development and in disease

(2016) Sybille Krauss   Frontiers in Bioscience-Landmark

Is a Normal TSH Synonymous With “Euthyroidism” in Levothyroxine Monotherapy?

(2016) Sarah J. Peterson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Unfolded protein response regulates yeast small GTPase Arl1p activation at late Golgi via phosphorylation of Arf GEF Syt1p

(2016) Jia-Wei Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Levothyroxine Replacement or Suppressive Therapy on Energy Expenditure and Body Composition

(2016) Mary H. Samuels et al.   THYROID

Gender Differences in the Neurobiology of Anxiety: Focus on Adult Hippocampal Neurogenesis

(2016) Alessandra Aparecida Marques et al.   NEURAL PLASTICITY

LMAN1 (ERGIC-53) is a potential carrier protein for matrix metalloproteinase-9 glycoprotein secretion

(2015) Tyler Duellman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prevalent Polymorphism in Thyroid Hormone-Activating Enzyme Leaves a Genetic Fingerprint That Underlies Associated Clinical Syndromes

(2015) Elizabeth A. McAninch et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine

(2015) Joao Pedro Werneck de Castro et al.   JOURNAL OF CLINICAL INVESTIGATION

Scope and limitations of iodothyronine deiodinases in hypothyroidism

(2015) Balázs Gereben et al.   Nature Reviews Endocrinology

A compensatory role for declarative memory in neurodevelopmental disorders

(2015) Michael T. Ullman et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice

(2015) Tomomi Aida et al.   GENOME BIOLOGY

New insights into the variable effectiveness of levothyroxine monotherapy for hypothyroidism

(2015) Elizabeth A McAninch et al.   Lancet Diabetes & Endocrinology

Defending plasma T3 is a biological priority

(2014) Sherine M. Abdalla et al.   CLINICAL ENDOCRINOLOGY

Characterization of a novel vasopressin V1b receptor antagonist, V1B-30N, in animal models of anxiety-like and depression-like behavior

(2014) Robert A. Hodgson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Mouse Geneticist's Practical Guide to CRISPR Applications

(2014) P. Singh et al.   GENETICS

Minimal requirements for ubiquitination-mediated regulation of thyroid hormone activation

(2014) Péter Egri et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Genome-Wide Investigation and Expression Analyses of WD40 Protein Family in the Model Plant Foxtail Millet (Setaria italica L.)

(2014) Awdhesh Kumar Mishra et al.   PLoS One

Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism

(2014) U. Schweizer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement

(2014) Jacqueline Jonklaas et al.   THYROID

The Type II Deiodinase Is Retrotranslocated to the Cytoplasm and Proteasomes via p97/Atx3 Complex

(2013) Rafael Arrojo e Drigo et al.   MOLECULAR ENDOCRINOLOGY

Hippocampal volumes differ across the mouse estrous cycle, can change within 24hours, and associate with cognitive strategies

(2013) Lily R. Qiu et al.   NEUROIMAGE

American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models

(2013) Antonio C. Bianco et al.   THYROID

Subcellular localization of ERGIC-53 under endoplasmic reticulum stress condition

(2012) S.-Y. Qin et al.   GLYCOBIOLOGY

Mechanisms of thyroid hormone action

(2012) Gregory A. Brent   JOURNAL OF CLINICAL INVESTIGATION

Neuronal Hypoxia Induces Hsp40-Mediated Nuclear Import of Type 3 Deiodinase As an Adaptive Mechanism to Reduce Cellular Metabolism

(2012) S. Jo et al.   JOURNAL OF NEUROSCIENCE

Protein Interaction Profiling of the p97 Adaptor UBXD1 Points to a Role for the Complex in Modulating ERGIC-53 Trafficking

(2012) Dale S. Haines et al.   MOLECULAR & CELLULAR PROTEOMICS

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

Early Cognitive Experience Prevents Adult Deficits in a Neurodevelopmental Schizophrenia Model

(2012) Heekyung Lee et al.   NEURON

Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength

(2012) J. H. Duncan Bassett et al.   PLoS Genetics

Levothyroxine Monotherapy Cannot Guarantee Euthyroidism in All Athyreotic Patients

(2011) Damiano Gullo et al.   PLoS One

Association Analyses of Variants in the DIO2 Gene with Early-Onset Type 2 Diabetes Mellitus in Pima Indians

(2011) Saraswathy Nair et al.   THYROID

Entry and Exit Mechanisms at the cis-Face of the Golgi Complex

(2011) A. Lorente-Rodriguez et al.   Cold Spring Harbor Perspectives in Biology

Assessment of Social Interaction Behaviors

(2011) Oksana Kaidanovich-Beilin et al.   Jove-Journal of Visualized Experiments

Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case–control study and meta-analysis

(2010) José Miguel Dora et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Paracrine signaling by glial cell–derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells

(2010) Beatriz C.G. Freitas et al.   JOURNAL OF CLINICAL INVESTIGATION

Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts

(2010) J. H. D. Bassett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Thr92Ala 5′ Type 2 Deiodinase Gene Polymorphism Is Associated with a Delayed Triiodothyronine Secretion in Response to the Thyrotropin-Releasing Hormone–Stimulation Test: A Pharmacogenomic Study

(2010) Peter W. Butler et al.   THYROID

Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites

(2009) Guy G. Potter et al.   Alzheimers & Dementia

Common Variation in theDIO2Gene Predicts Baseline Psychological Well-Being and Response to Combination Thyroxine Plus Triiodothyronine Therapy in Hypothyroid Patients

(2009) Vijay Panicker et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

The E3 Ubiquitin Ligase TEB4 Mediates Degradation of Type 2 Iodothyronine Deiodinase

(2009) A. M. Zavacki et al.   MOLECULAR AND CELLULAR BIOLOGY

Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1

(2008) Balázs Gereben et al.   ENDOCRINE REVIEWS

Neurodevelopmental and Neurophysiological Actions of Thyroid Hormone

(2008) G. R. Williams   JOURNAL OF NEUROENDOCRINOLOGY