Sirt5 Deficiency Causes Posttranslational Protein Malonylation and Dysregulated Cellular Metabolism in Chondrocytes Under Obesity Conditions

GC–MS metabolic profiling reveals fructose-2,6-bisphosphate regulates branched chain amino acid metabolism in the heart during fasting

(2019) Albert Batushansky et al.   Metabolomics

Correlation Network Analysis Shows Divergent Effects of a Long-Term, High-Fat Diet and Exercise on Early-Stage Osteoarthritis Phenotypes in Mice

(2019) Timothy M. Griffin et al.   Journal of Sport and Health Science

GC–MS method for metabolic profiling of mouse femoral head articular cartilage reveals distinct effects of tissue culture and development

(2019) A. Batushansky et al.   OSTEOARTHRITIS AND CARTILAGE

BCAA Catabolic Defect Alters Glucose Metabolism in Lean Mice

(2019) Ji Wang et al.   Frontiers in Physiology

The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications

(2018) Chris Carrico et al.   Cell Metabolism

Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology

(2018) Surinder Kumar et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress

(2018) Alec G. Trub et al.   TRENDS IN BIOCHEMICAL SCIENCES

Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner

(2018) Yun-Qian Wang et al.   Nature Communications

The role of metabolism in the pathogenesis of osteoarthritis

(2017) Ali Mobasheri et al.   Nature Reviews Rheumatology

Knee osteoarthritis has doubled in prevalence since the mid-20th century

(2017) Ian J. Wallace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study

(2016) Anne-Laurence Tomi et al.   ANNALS OF THE RHEUMATIC DISEASES

SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense

(2016) Lisha Zhou et al.   EMBO REPORTS

Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis

(2016) Ronald K. June et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

(2016) Sushabhan Sadhukhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth

(2016) Ye Xiangyun et al.   Oncotarget

Review: Metabolic Regulation of Inflammation in Osteoarthritis

(2016) Francis Berenbaum et al.   Arthritis & Rheumatology

Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis

(2016) Yao Fu et al.   Arthritis & Rheumatology

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

(2015) Yuya Nishida et al.   MOLECULAR CELL

Mitochondrial Biogenesis Is Impaired in Osteoarthritis Chondrocytes but Reversible via Peroxisome Proliferator-Activated Receptor γ Coactivator 1α

(2015) Yun Wang et al.   Arthritis & Rheumatology

The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study

(2014) A W Visser et al.   ANNALS OF THE RHEUMATIC DISEASES

Lysine Malonylation Is Elevated in Type 2 Diabetic Mouse Models and Enriched in Metabolic Associated Proteins

(2014) Yipeng Du et al.   MOLECULAR & CELLULAR PROTEOMICS

Towards elucidating the role of SirT1 in osteoarthritis

(2013) Mona Dvir-Ginzberg   Frontiers in Bioscience-Landmark

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

Metabolic syndrome meets osteoarthritis

(2012) Qi Zhuo et al.   Nature Reviews Rheumatology

Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α

(2011) Robert Terkeltaub et al.   ARTHRITIS AND RHEUMATISM

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms

(2010) Nobuko Matsushita et al.   GENES TO CELLS

Lipid metabolism and osteoarthritis: Lessons from atherosclerosis

(2010) Vasiliki Gkretsi et al.   PROGRESS IN LIPID RESEARCH

Fatty acid metabolism: target for metabolic syndrome

(2008) Salih J. Wakil et al.   JOURNAL OF LIPID RESEARCH

Primary culture and phenotyping of murine chondrocytes

(2008) Marjolaine Gosset et al.   Nature Protocols