Nicotinic Acetylcholine Receptor Involvement in Inflammatory Bowel Disease and Interactions with Gut Microbiota

Expression of α3β2β4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists

(2020) Arik J. Hone et al.   JOURNAL OF NEUROCHEMISTRY

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells

(2020) Narges Dargahi et al.   PLoS One

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Characteristics and prognosis of patients with inflammatory bowel disease during the SARS-CoV-2 pandemic in the Basque Country (Spain)

(2020) Iago Rodríguez-Lago et al.   GASTROENTEROLOGY

Digestive system is a potential route of COVID-19: an analysis of single-cell coexpression pattern of key proteins in viral entry process

(2020) Hao Zhang et al.   GUT

Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis

(2020) Ren Mao et al.   Lancet Gastroenterology & Hepatology

Systematic review on IBD patients with COVID-19: it is time to take stock

(2020) Ferdinando D’Amico et al.   Clinical Gastroenterology and Hepatology

Alterations of the Gut Microbiota in Patients With Coronavirus Disease 2019 or H1N1 Influenza

(2020) Silan Gu et al.   CLINICAL INFECTIOUS DISEASES

Depicting SARS-CoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19

(2020) Tao Zuo et al.   GUT

Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications

(2020) Konstantinos Farsalinos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of extrinsic innervation in the abdominal intestines of human embryos

(2020) Nutmethee Kruepunga et al.   JOURNAL OF ANATOMY

Combined administration of SHP2 inhibitor SHP099 and the α7nAChR agonist PNU282987 protect mice against DSS‑induced colitis

(2020) Junhua Xiao et al.   Molecular Medicine Reports

Functional Roles of B‐Vitamins in the Gut and Gut Microbiome

(2020) Takashi Uebanso et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Distinct conformational states of SARS-CoV-2 spike protein

(2020) Yongfei Cai et al.   SCIENCE

Cytokine Release Syndrome (CRS) and Nicotine in COVID-19 Patients: Trying to Calm the Storm

(2020) Jesus Gonzalez-Rubio et al.   Frontiers in Immunology

Neural control of Gut homeostasis

(2020) Nasser Abdullah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The α9α10 nicotinic acetylcholine receptors antagonist α-conotoxin RgIA reverses colitis signs in murine dextran sodium sulfate model

(2020) Shakir D. AlSharari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Vagal‐α7nAChR signalling attenuates allergic asthma responses and facilitates asthma tolerance by regulating inflammatory group 2 innate lymphoid cells

(2020) Xintong Feng et al.   IMMUNOLOGY AND CELL BIOLOGY

Incidence, Clinical Characteristics, and Evolution of SARS-CoV-2 Infection in Patients With Inflammatory Bowel Disease: A Single-Center Study in Madrid, Spain

(2020) Ivan Guerra et al.   INFLAMMATORY BOWEL DISEASES

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Amyloid Beta Peptide (Aβ1-42) Reverses the Cholinergic Control of Monocytic IL-1β Release

(2020) Katrin Richter et al.   Journal of Clinical Medicine

SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role

(2020) Ahmad Ud Din et al.   BIOMEDICINE & PHARMACOTHERAPY

COVID-19 induced ARDS, and the use of galantamine to activate the cholinergic anti-inflammatory pathway

(2020) Farrukh Ahmad   MEDICAL HYPOTHESES

Learnings from 30 years of reported efficacy and safety of vagus nerve stimulation (VNS) for epilepsy treatment: A critical review

(2020) Dènahin Hinnoutondji Toffa et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Nicotine-evoked currents in human primary sensory neurons

(2019) Xiulin Zhang et al.   JOURNAL OF PAIN

Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice

(2019) Sami Alzarea et al.   BEHAVIOURAL BRAIN RESEARCH

Four-week administration of nicotinemoderately impacts blood metabolic profile and gut microbiota in a diet-dependent manner

(2019) Ran Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism

(2019) Jonathan Scheiman et al.   NATURE MEDICINE

RgIA4 Accelerates Recovery from Paclitaxel-Induced Neuropathic Pain in Rats

(2019) Peter N. Huynh et al.   Marine Drugs

Distinct Evolutionary Trajectories of Neuronal and Hair Cell Nicotinic Acetylcholine Receptors

(2019) Irina Marcovich et al.   MOLECULAR BIOLOGY AND EVOLUTION

Impaired Expression of Neuregulin 1 and Nicotinic Acetylcholine Receptor β4 Subunit in Diverticular Disease

(2019) Martina Barrenschee et al.   Frontiers in Cellular Neuroscience

Vagus nerve cholinergic circuitry to the liver and the gastrointestinal tract in the neuroimmune communicatome

(2018) Christine N. Metz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Interaction of the α7-nicotinic subunit with its human-specific duplicated dupα7 isoform in mammalian cells: Relevance in human inflammatory responses

(2018) María C Maldifassi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotine treatment ameliorates DSS-induced colitis by suppressing MAdCAM-1 expression and leukocyte recruitment

(2018) Koji Maruta et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Comparative transcriptome profiling of the human and mouse dorsal root ganglia

(2018) Pradipta Ray et al.   PAIN

Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies

(2018) Bani Ahluwalia et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways

(2018) Shakeeb A. Wazea et al.   Scientific Reports

Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders

(2018) Sigrid Breit et al.   Frontiers in Psychiatry

Stress burden and neuroendocrine regulation of cytokine production in patients with ulcerative colitis in remission

(2018) Harald Engler et al.   PSYCHONEUROENDOCRINOLOGY

The Human Gut Microbiome – A Potential Controller of Wellness and Disease

(2018) Zhi Y. Kho et al.   Frontiers in Microbiology

Spotlight on cervical vagus nerve stimulation for the treatment of primary headache disorders: a review

(2018) Ilana S. Lendvai et al.   Journal of Pain Research

Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence

(2017) N. Y. Lai et al.   JOURNAL OF INTERNAL MEDICINE

Mucin Cross-Feeding of Infant Bifidobacteria and Eubacterium hallii

(2017) Vera Bunesova et al.   MICROBIAL ECOLOGY

Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon

(2017) I. Kaji et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain

(2017) Haylie K. Romero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical presentation of Crohn’s, ulcerative colitis, and indeterminate colitis: Symptoms, extraintestinal manifestations, and disease phenotypes

(2017) Yangyang R. Yu et al.   Seminars in Pediatric Surgery

RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia

(2017) Sean B. Christensen et al.   Frontiers in Cellular Neuroscience

Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10

(2017) Anna Zakrzewicz et al.   Frontiers in Cellular Neuroscience

Bifidobacterium thermophilum RBL67 impacts on growth and virulence gene expression of Salmonella enterica subsp. enterica serovar Typhimurium

(2016) Sabine A. Tanner et al.   BMC MICROBIOLOGY

The α9α10 nicotinic receptor antagonist α-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment

(2016) Alessandra Pacini et al.   EXPERIMENTAL NEUROLOGY

Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon

(2016) Izumi Kaji et al.   JOURNAL OF PHYSIOLOGY-LONDON

Chronic vagus nerve stimulation in Crohn's disease: a 6-month follow-up pilot study

(2016) B. Bonaz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Phosphocholine – an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors

(2016) K. Richter et al.   Scientific Reports

Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release

(2015) Andreas Hecker et al.   JOURNAL OF IMMUNOLOGY

Changes in Nicotinic Neurotransmission during Enteric Nervous System Development

(2015) J. P. P. Foong et al.   JOURNAL OF NEUROSCIENCE

Involvement of stimulation of α7 nicotinic acetylcholine receptors in the suppressive effect of tropisetron on dextran sulfate sodium-induced colitis in mice

(2015) Yuichi Tasaka et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors

(2015) Jeffrey S. Wieskopf et al.   Science Translational Medicine

Usefulness of α7 Nicotinic Receptor Messenger RNA Levels in Peripheral Blood Mononuclear Cells as a Marker for Cholinergic Antiinflammatory Pathway Activity in Septic Patients: Results of a Pilot Study

(2014) José L. Cedillo et al.   JOURNAL OF INFECTIOUS DISEASES

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(2014) Ben Lu et al.   MOLECULAR MEDICINE

Localization of α7 nicotinic acetylcholine receptor mRNA and protein within the cholinergic anti-inflammatory pathway

(2014) A.M. Downs et al.   NEUROSCIENCE

α-Conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement

(2014) Lorenzo Di Cesare Mannelli et al.   PAIN

Neuro-Anatomical Evidence Indicating Indirect Modulation of Macrophages by Vagal Efferents in the Intestine but Not in the Spleen

(2014) Cathy Cailotto et al.   PLoS One

Duodenal-Mucosal Bacteria Associated with Celiac Disease in Children

(2013) Ester Sánchez et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent

(2013) Laura Wrzosek et al.   BMC BIOLOGY

Stimulation of the α7 Nicotinic Acetylcholine Receptor Protects Against Sepsis by Inhibiting Toll-like Receptor via Phosphoinositide 3-Kinase Activation

(2013) Tae-Hoon Kim et al.   JOURNAL OF INFECTIOUS DISEASES

Single-channel properties of α3β4, α3β4α5 and α3β4β2 nicotinic acetylcholine receptors in mice lacking specific nicotinic acetylcholine receptor subunits

(2013) Anna Ciuraszkiewicz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pharmacological Cholinergic Stimulation as a Therapeutic Tool in Experimental Necrotizing Pancreatitis

(2013) Lutz Schneider et al.   PANCREAS

Smoking Cessation Induces Profound Changes in the Composition of the Intestinal Microbiota in Humans

(2013) Luc Biedermann et al.   PLoS One

Vagus Nerve Stimulation Attenuates Intestinal Epithelial Tight Junctions Disruption in Endotoxemic Mice Through α7 Nicotinic Acetylcholine Receptors

(2013) Hui Zhou et al.   SHOCK

Comparative functional expression of nAChR subtypes in rodent DRG neurons

(2013) Nathan J. Smith et al.   Frontiers in Cellular Neuroscience

Commensal Clostridia: leading players in the maintenance of gut homeostasis

(2013) Loris R Lopetuso et al.   Gut Pathogens

Targeting α-7 Nicotinic Acetylcholine Receptor in the Enteric Nervous System

(2012) Todd W. Costantini et al.   AMERICAN JOURNAL OF PATHOLOGY

Nicotine suppresses hyperexcitability of colonic sensory neurons and visceral hypersensivity in mouse model of colonic inflammation

(2012) Galya R. Abdrakhmanova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Transcutaneous Auricular Vagus Nerve Stimulation Protects Endotoxemic Rat from Lipopolysaccharide-Induced Inflammation

(2012) Yu Xue Zhao et al.   Evidence-based Complementary and Alternative Medicine

The vagal innervation of the gut and immune homeostasis

(2012) Gianluca Matteoli et al.   GUT

Rethinking inflammation: neural circuits in the regulation of immunity

(2012) Peder S. Olofsson et al.   IMMUNOLOGICAL REVIEWS

Cultivable and Pyrosequenced Fecal Microflora in Centenarians and Young Subjects

(2012) Lorenzo Drago et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

The Role of the Vagus Nerve: Modulation of the Inflammatory Reaction in Murine Polymicrobial Sepsis

(2012) Wolfram Kessler et al.   MEDIATORS OF INFLAMMATION

Activation of the alpha-7 nicotinic acetylcholine receptor (α7 nAchR) reverses referred mechanical hyperalgesia induced by colonic inflammation in mice

(2012) Robson Costa et al.   NEUROPHARMACOLOGY

Parasympathetic Stimulation Via the Vagus Nerve Prevents Systemic Organ Dysfunction by Abrogating Gut Injury and Lymph Toxicity in Trauma and Hemorrhagic Shock

(2012) Gal Levy et al.   SHOCK

Side-stream smoking reduces intestinal inflammation and increases expression of tight junction proteins

(2012) Hui Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Nicotinic acetylcholine receptors in dorsal root ganglion neurons include the α6β4* subtype

(2011) Arik J. Hone et al.   FASEB JOURNAL

An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota

(2011) Ian B Jeffery et al.   GUT

Nitric oxide regulation of colonic epithelial ion transport: a novel role for enteric glia in the myenteric plexus

(2011) Sarah J. MacEachern et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cigarette smoke decreases organic acids levels and population of bifidobacterium in the caecum of rats

(2011) Koichi Tomoda et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

(2011) M. Rosas-Ballina et al.   SCIENCE

Effects of the α7 Nicotinic Acetylcholine Receptor Agonist Gts-21 on the Innate Immune Response in Humans

(2011) Matthijs Kox et al.   SHOCK

α7-nAChR-mediated suppression of hyperexcitability of colonic dorsal root ganglia neurons in experimental colitis

(2010) Galya R. Abdrakhmanova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Stimulation of Alpha7 Nicotinic Acetylcholine Receptor by Nicotine Attenuates Inflammatory Response in Macrophages and Improves Survival in Experimental Model of Sepsis Through Heme Oxygenase-1 Induction

(2010) Konstantin Tsoyi et al.   ANTIOXIDANTS & REDOX SIGNALING

Anti-inflammatory effect of vagus nerve stimulation in a rat model of inflammatory bowel disease

(2010) J. Meregnani et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes

(2010) Reinhard David et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Genomic Insights into Bifidobacteria

(2010) J.-H. Lee et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The role of toxin A and toxin B in Clostridium difficile infection

(2010) Sarah A. Kuehne et al.   NATURE

Experimental Therapeutic Strategies for Severe Sepsis

(2009) William R. Parrish et al.   Annals of the New York Academy of Sciences

Vagus Nerve Activity Augments Intestinal Macrophage Phagocytosis via Nicotinic Acetylcholine Receptor α4β2

(2009) Esmerij P. van der Zanden et al.   GASTROENTEROLOGY

The Vagus Nerve and Nicotinic Receptors Involve Inhibition of HMGB1 Release and Early Pro-inflammatory Cytokines Function in Collagen-Induced Arthritis

(2009) Tong Li et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Cholinergic protection via α7 nicotinic acetylcholine receptors and PI3K-Akt pathway in LPS-induced neuroinflammation

(2009) Ethika Tyagi et al.   NEUROCHEMISTRY INTERNATIONAL

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

Autonomic ganglia, acetylcholine receptor antibodies, and autoimmune ganglionopathy

(2008) Steven Vernino et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Impaired activation of celiac ganglion neurons in vivo after damage to their sympathetic nerve terminals

(2008) Thomas O. Mundinger et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Expression of nicotinic acetylcholine receptors and subunit messenger RNAs in the enteric nervous system of the neonatal rat

(2008) A. Garza et al.   NEUROSCIENCE

Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia

(2008) M. Rosas-Ballina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA