Exogenous Alpha-Synuclein Evoked Parkin Downregulation Promotes Mitochondrial Dysfunction in Neuronal Cells. Implications for Parkinson’s Disease Pathology

P2X7 Receptor is Involved in Mitochondrial Dysfunction Induced by Extracellular Alpha Synuclein in Neuroblastoma SH-SY5Y Cells

(2020) Anna Wilkaniec et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

(2019) Xinhe Wang et al.   Acta Neuropathologica Communications

Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose

(2019) Anna-Carin Hoffmann et al.   Scientific Reports

Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons

(2019) Goutham K. Ganjam et al.   Cell Death & Disease

Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson’s models

(2018) Atossa Shaltouki et al.   ACTA NEUROPATHOLOGICA

Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson’s Disease Etiopathology

(2018) Anna Wilkaniec et al.   MOLECULAR NEUROBIOLOGY

Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson’s disease

(2018) Jialong Chen et al.   Cell Death & Disease

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells

(2017) Anna Wilkaniec et al.   Purinergic Signalling

Mitochondrial fusion, fission, and mitochondrial toxicity

(2017) Joel N. Meyer et al.   TOXICOLOGY

Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria

(2017) Bin Xiao et al.   Cell Death & Disease

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

(2017) Babette C. Hammerling et al.   Nature Communications

αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease

(2017) Victorio Martin Pozo Devoto et al.   Scientific Reports

Lysosomal adaptation: How cells respond to lysosomotropic compounds

(2017) Shuyan Lu et al.   PLoS One

Involvement of mortalin/GRP75/mthsp70 in the mitochondrial impairments induced by A53T mutant α-synuclein

(2015) Feng-tao Liu et al.   BRAIN RESEARCH

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

(2015) Alicia M. Pickrell et al.   NEURON

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

(2015) Stanley B. Prusiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Axon degeneration and PGC-1 -mediated protection in a zebrafish model of  -synuclein toxicity

(2014) K. C. O'Donnell et al.   Disease Models & Mechanisms

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

The prevalence of Parkinson's disease: A systematic review and meta-analysis

(2014) Tamara Pringsheim et al.   MOVEMENT DISORDERS

Disturbed mitochondrial dynamics and neurodegenerative disorders

(2014) Florence Burté et al.   Nature Reviews Neurology

Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein

(2014) Sudhakar Raja Subramaniam et al.   NEUROBIOLOGY OF DISEASE

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

(2013) Selcuk A. Tanik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Toxicity of extracellular secreted alpha-synuclein: Its role in nitrosative stress and neurodegeneration

(2013) Anna Wilkaniec et al.   NEUROCHEMISTRY INTERNATIONAL

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson’s disease

(2012) Almas Siddiqui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons

(2012) Seungmin Lee et al.   HUMAN MOLECULAR GENETICS

Conditional Expression of Parkinson's Disease-Related Mutant  -Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1

(2012) X. Lin et al.   JOURNAL OF NEUROSCIENCE

Mitophagy and Parkinson's disease: Be eaten to stay healthy

(2012) Rosa L.A. de Vries et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Stress-Induced Phosphorylation and Proteasomal Degradation of Mitofusin 2 Facilitates Mitochondrial Fragmentation and Apoptosis

(2012) Guillaume P. Leboucher et al.   MOLECULAR CELL

Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1

(2012) Ya-Xing Gui et al.   NEUROBIOLOGY OF AGING

Analysis of neural subtypes reveals selective mitochondrial dysfunction in dopaminergic neurons from parkin mutants

(2012) J. L. Burman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dynamics in neurodegeneration

(2012) Kie Itoh et al.   TRENDS IN CELL BIOLOGY

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesis

(2011) Matthew E. Gegg et al.   Autophagy

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy

(2011) Vinay Choubey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

(2011) Liliane Glauser et al.   JOURNAL OF NEUROCHEMISTRY

PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease

(2011) Elahe Taherzadeh-Fard et al.   Molecular Neurodegeneration

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics

(2010) Stephane G Rolland et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

α-Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: Implications in Parkinson's disease

(2010) Kalpita Banerjee et al.   FEBS LETTERS

Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming

(2010) Wen-Xing Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transgenic Overexpression of α-Synuclein and Not Its Related Pathology Associates with Complex I Inhibition

(2010) Virginie Loeb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Co-regulation of nuclear respiratory factor-1 by NF B and CREB links LPS-induced inflammation to mitochondrial biogenesis

(2010) H. B. Suliman et al.   JOURNAL OF CELL SCIENCE

The role of parkin in familial and sporadic Parkinson's disease

(2010) Ted M. Dawson et al.   MOVEMENT DISORDERS

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease

(2010) Alessandro Prigione et al.   NEUROSCIENCE LETTERS

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

(2010) Shankar J. Chinta et al.   NEUROSCIENCE LETTERS

The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway

(2010) Angela C. Poole et al.   PLoS One

PGC-1 , A Potential Therapeutic Target for Early Intervention in Parkinson's Disease

(2010) B. Zheng et al.   Science Translational Medicine

MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission

(2009) Emélie Braschi et al.   EMBO REPORTS

Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells

(2009) Mordhwaj S. Parihar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion

(2009) Zhiyin Song et al.   MOLECULAR BIOLOGY OF THE CELL

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

(2009) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

α-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity

(2009) Guangwei Liu et al.   NEUROSCIENCE LETTERS

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial function and morphology are impaired inparkin-mutant fibroblasts

(2008) Heather Mortiboys et al.   ANNALS OF NEUROLOGY

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY