The histone demethylase KDM5 is required for synaptic structure and function at the Drosophila neuromuscular junction

POU domain motif3 (Pdm3) induces wingless (wg) transcription and is essential for development of larval neuromuscular junctions in Drosophila

(2020) Yeon Kim et al.   Scientific Reports

A Connected Network of Interacting Proteins Is Involved in Human-Tau Toxicity in Drosophila

(2020) Sébastien Feuillette et al.   Frontiers in Neuroscience

Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation

(2020) Christina N. Vallianatos et al.   Communications Biology

Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance

(2019) Kun Chen et al.   Cell Host & Microbe

The pre-synaptic fusion machinery

(2019) Axel T Brunger et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Intellectual disability and autism spectrum disorders ‘on the fly’: insights from Drosophila

(2019) Mireia Coll-Tané et al.   Disease Models & Mechanisms

Dissecting the Genetics of Autism Spectrum Disorders: A Drosophila Perspective

(2019) Paola Bellosta et al.   Frontiers in Physiology

The histone demethylase KDM5 controls developmental timing in Drosophila by promoting prothoracic gland endocycles

(2019) Coralie Drelon et al.   DEVELOPMENT

The Histone Demethylase KDM5 Is Essential for Larval Growth inDrosophila

(2018) Coralie Drelon et al.   GENETICS

Dendritic structural plasticity and neuropsychiatric disease

(2018) Marc P. Forrest et al.   NATURE REVIEWS NEUROSCIENCE

DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability

(2018) Carlos HM Rodrigues et al.   NUCLEIC ACIDS RESEARCH

Glutamatergic synapses in neurodevelopmental disorders

(2018) Edoardo Moretto et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5

(2018) Sumaira Zamurrad et al.   Cell Reports

Neurexin–Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction

(2018) Guanglin Xing et al.   eLife

The Histone Demethylase KDM5 Is Essential for Larval Growth inDrosophila

(2018) Coralie Drelon et al.   GENETICS

Altered Gene-Regulatory Function of KDM5C by a Novel Mutation Associated With Autism and Intellectual Disability

(2018) Christina N. Vallianatos et al.   Frontiers in Molecular Neuroscience

Novel KDM5B splice variants identified in patients with developmental disorders: Functional consequences

(2018) Nicolas Lebrun et al.   GENE

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies

(2017) Peter D. Stenson et al.   HUMAN GENETICS

Histone Lysine Methylation and Neurodevelopmental Disorders

(2017) Jeong-Hoon Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic Etiology of Intellectual Disability

(2017) Shigeki Iwase et al.   JOURNAL OF NEUROSCIENCE

Input-Specific Plasticity and Homeostasis at the Drosophila Larval Neuromuscular Junction

(2017) Zachary L. Newman et al.   NEURON

Hyperactive locomotion in aDrosophilamodel is a functional readout for the synaptic abnormalities underlying fragile X syndrome

(2017) Risa Kashima et al.   Science Signaling

Loss of Kdm5c Causes Spurious Transcription and Prevents the Fine-Tuning of Activity-Regulated Enhancers in Neurons

(2017) Marilyn Scandaglia et al.   Cell Reports

Hyperactive locomotion in aDrosophilamodel is a functional readout for the synaptic abnormalities underlying fragile X syndrome

(2017) Risa Kashima et al.   Science Signaling

The H3K4me3/2 histone demethylase RBR-2 controls axon guidance by repressing the actin-remodeling genewsp-1

(2016) Luca Mariani et al.   DEVELOPMENT

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

(2016) Maia Vinogradova et al.   Nature Chemical Biology

Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling

(2016) Paulo Navarro-Costa et al.   Nature Communications

A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation

(2016) Shigeki Iwase et al.   Cell Reports

The Presynaptic Microtubule Cytoskeleton in Physiological and Pathological Conditions: Lessons from Drosophila Fragile X Syndrome and Hereditary Spastic Paraplegias

(2016) Felipe J. Bodaleo et al.   Frontiers in Molecular Neuroscience

Glutamate Synapses in Human Cognitive Disorders

(2015) Lenora Volk et al.   Annual Review of Neuroscience

Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity

(2015) Emily Brookes et al.   HUMAN MOLECULAR GENETICS

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases

(2015) John R. Horton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AgingDrosophila melanogasterdisplay altered pre- and postsynaptic ultrastructure at adult neuromuscular junctions

(2015) Nicole Wagner et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Synaptic dysfunction and septin protein family members in neurodegenerative diseases

(2015) Mikael Marttinen et al.   Molecular Neurodegeneration

Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders

(2015) Christina N Vallianatos et al.   Epigenomics

The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif

(2015) Xingyin Liu et al.   Cell Reports

TOG Proteins Are Spatially Regulated by Rac-GSK3β to Control Interphase Microtubule Dynamics

(2015) Kathryn P. Trogden et al.   PLoS One

H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency

(2014) Bérénice A. Benayoun et al.   CELL

A Group of Segmental Premotor Interneurons Regulates the Speed of Axial Locomotion in Drosophila Larvae

(2014) Hiroshi Kohsaka et al.   CURRENT BIOLOGY

KDM5C mutational screening among males with intellectual disability suggestive of X-Linked inheritance and review of the literature

(2014) Thainá Fernandez Gonçalves et al.   European Journal of Medical Genetics

Synapsin Regulates Activity-Dependent Outgrowth of Synaptic Boutons at the Drosophila Neuromuscular Junction

(2014) A. Vasin et al.   JOURNAL OF NEUROSCIENCE

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

KDM5 Interacts with Foxo to Modulate Cellular Levels of Oxidative Stress

(2014) Xingyin Liu et al.   PLoS Genetics

A comparison of methods for differential expression analysis of RNA-seq data

(2013) Charlotte Soneson et al.   BMC BIOINFORMATICS

From neural development to cognition: unexpected roles for chromatin

(2013) Jehnna L. Ronan et al.   NATURE REVIEWS GENETICS

Development and plasticity of the Drosophila larval neuromuscular junction

(2013) Kaushiki P. Menon et al.   Wiley Interdisciplinary Reviews-Developmental Biology

FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption

(2012) Inna V. Nechipurenko et al.   JOURNAL OF CELL BIOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

A Protein Complex Network of Drosophila melanogaster

(2011) K.G. Guruharsha et al.   CELL

S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development

(2011) Ling Cheng et al.   JOURNAL OF CELL BIOLOGY

Deep sequencing reveals 50 novel genes for recessive cognitive disorders

(2011) Hossein Najmabadi et al.   NATURE

The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy

(2010) A. A. Long et al.   JOURNAL OF CELL SCIENCE

Synaptic Activity Controls Dendritic Spine Morphology by Modulating eEF2-Dependent BDNF Synthesis

(2010) C. Verpelli et al.   JOURNAL OF NEUROSCIENCE

Septins Regulate Developmental Switching from Microdomain to Nanodomain Coupling of Ca2+ Influx to Neurotransmitter Release at a Central Synapse

(2010) Yi-Mei Yang et al.   NEURON

Drosophila Neuroligin 1 Promotes Growth and Postsynaptic Differentiation at Glutamatergic Neuromuscular Junctions

(2010) Daniel Banovic et al.   NEURON

Essential Functions of the Histone Demethylase Lid

(2010) Ling Li et al.   PLoS Genetics

Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype–phenotype correlation

(2009) Sinitdhorn Rujirabanjerd et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Microtubule assembly, organization and dynamics in axons and dendrites

(2009) Cecilia Conde et al.   NATURE REVIEWS NEUROSCIENCE

PANTHER version 7: improved phylogenetic trees, orthologs and collaboration with the Gene Ontology Consortium

(2009) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Cyclin-Dependent Kinase 5 Phosphorylation of Human Septin SEPT5 (hCDCrel-1) Modulates Exocytosis

(2008) N. D. Amin et al.   JOURNAL OF NEUROSCIENCE