A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication
Authors
Keywords
-
Journal
Nature Communications
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-01-28
DOI
10.1038/s41467-021-20900-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
- (2020) Chaolin Huang et al. LANCET
- A Novel Coronavirus from Patients with Pneumonia in China, 2019
- (2020) Na Zhu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia
- (2020) Qun Li et al. NEW ENGLAND JOURNAL OF MEDICINE
- The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2
- (2020) Nature Microbiology
- Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics
- (2020) Arun K. Ghosh et al. ChemMedChem
- Coronavirus Disease 2019 (COVID-19) in Italy
- (2020) Edward Livingston et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
- (2020) Calvin J. Gordon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
- (2020) Zhenming Jin et al. NATURE
- Remdesivir for the Treatment of Covid-19 — Preliminary Report
- (2020) John H. Beigel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
- (2020) Linlin Zhang et al. SCIENCE
- Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
- (2020) Wanchao Yin et al. SCIENCE
- Sirtuin 1 Inhibiting Thiocyanates (S1th)—A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases
- (2020) Nathalie Wössner et al. Frontiers in Oncology
- Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode
- (2020) Jian Li et al. Science Bulletin
- DIALS: implementation and evaluation of a new integration package
- (2018) Graeme Winter et al. Acta Crystallographica Section D-Structural Biology
- From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design
- (2014) Rolf Hilgenfeld FEBS Journal
- Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies
- (2013) Pillaiyar Thanigaimalai et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Recent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterization
- (2013) Anton Simeonov Expert Opinion on Drug Discovery
- Autoprocessing mechanism of severe acute respiratory syndrome coronavirus 3C-like protease (SARS-CoV 3CLpro) from its polyproteins
- (2013) Tomonari Muramatsu et al. FEBS Journal
- Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease
- (2012) Jon Jacobs et al. JOURNAL OF MEDICINAL CHEMISTRY
- REFMAC5 for the refinement of macromolecular crystal structures
- (2011) Garib N. Murshudov et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Maturation Mechanism of Severe Acute Respiratory Syndrome (SARS) Coronavirus 3C-like Proteinase
- (2010) Chunmei Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular replacement withMOLREP
- (2009) Alexei Vagin et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors
- (2008) Arun K. Ghosh et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A Structural View of the Inactivation of the SARS Coronavirus Main Proteinase by Benzotriazole Esters
- (2008) Koen H.G. Verschueren et al. CHEMISTRY & BIOLOGY
- Mechanism for Controlling the Dimer-Monomer Switch and Coupling Dimerization to Catalysis of the Severe Acute Respiratory Syndrome Coronavirus 3C-Like Protease
- (2008) J. Shi et al. JOURNAL OF VIROLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation