From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features

(2014) Jian Lei et al.   ANTIVIRAL RESEARCH

X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases

(2014) Yahira M. Báez-Santos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease

(2014) Kiira Ratia et al.   PLoS Pathogens

Structural basis for catalysis and ubiquitin recognition by theSevere acute respiratory syndrome coronaviruspapain-like protease

(2014) Chi-Yuan Chou et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Clinical management and infection control of SARS: Lessons learned

(2013) Vincent C.C. Cheng et al.   ANTIVIRAL RESEARCH

From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses

(2013) Rolf Hilgenfeld et al.   ANTIVIRAL RESEARCH

Receptor recognition and cross-species infections of SARS coronavirus

(2013) Fang Li   ANTIVIRAL RESEARCH

SARS-CoV ORF1b-encoded nonstructural proteins 12–16: Replicative enzymes as antiviral targets

(2013) Lorenzo Subissi et al.   ANTIVIRAL RESEARCH

Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS

(2013) Jan Felix Drexler et al.   ANTIVIRAL RESEARCH

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

(2013) Mark Turlington et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Autoprocessing mechanism of severe acute respiratory syndrome coronavirus 3C-like protease (SARS-CoV 3CLpro) from its polyproteins

(2013) Tomonari Muramatsu et al.   FEBS Journal

3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

(2013) J. Tan et al.   JOURNAL OF VIROLOGY

Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study

(2013) Chantal BEM Reusken et al.   LANCET INFECTIOUS DISEASES

Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation

(2013) Bart L Haagmans et al.   LANCET INFECTIOUS DISEASES

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

A decade after SARS: strategies for controlling emerging coronaviruses

(2013) Rachel L. Graham et al.   NATURE REVIEWS MICROBIOLOGY

The newly emerged SARS-Like coronavirus HCoV-EMC also has an “Achilles’ heel”: current effective inhibitor targeting a 3C-like protease

(2013) Zhilin Ren et al.   Protein & Cell

Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases

(2012) Chi-Pang Chuck et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

(2011) Lili Zhu et al.   ANTIVIRAL RESEARCH

Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors

(2011) Kenichi Akaji et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activation and maturation of SARS-CoV main protease

(2011) Bin Xia et al.   Protein & Cell

The VIZIER project: Overview; expectations; and achievements

(2010) Bruno Coutard et al.   ANTIVIRAL RESEARCH

Structure-based antivirals for emerging and neglected RNA viruses: an emerging field for medicinal chemistry in academia

(2010) Rolf Hilgenfeld   Future Medicinal Chemistry

Maturation Mechanism of Severe Acute Respiratory Syndrome (SARS) Coronavirus 3C-like Proteinase

(2010) Chunmei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation

(2010) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases

(2010) M. A. Clementz et al.   JOURNAL OF VIROLOGY

Coexistence of Different Genotypes in the Same Bat and Serological Characterization of Rousettus Bat Coronavirus HKU9 Belonging to a Novel Betacoronavirus Subgroup

(2010) S. K. P. Lau et al.   JOURNAL OF VIROLOGY

Coronavirus Genomics and Bioinformatics Analysis

(2010) Patrick C. Y. Woo et al.   Viruses-Basel

Three-dimensional domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease

(2010) Shengnan Zhang et al.   Protein & Cell

Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode

(2010) Shuai Chen et al.   Protein & Cell

Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds

(2009) Cheng-Chung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome−Coronavirus Papain-Like Protease

(2009) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF- B Signaling

(2009) M. Frieman et al.   JOURNAL OF VIROLOGY

Sensitized Detection of Inhibitory Fragments and Iterative Development of Non-Peptidic Protease Inhibitors by Dynamic Ligation Screening

(2008) Marco Florian Schmidt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors

(2008) Arun K. Ghosh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro

(2008) Usman Bacha et al.   Chemical Biology & Drug Design

A Structural View of the Inactivation of the SARS Coronavirus Main Proteinase by Benzotriazole Esters

(2008) Koen H.G. Verschueren et al.   CHEMISTRY & BIOLOGY

Genomic characterizations of bat coronaviruses (1A, 1B and HKU8) and evidence for co-infections in Miniopterus bats

(2008) D. K. W. Chu et al.   JOURNAL OF GENERAL VIROLOGY

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

(2008) K. Ratia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum

(2008) Kèvin Knoops et al.   PLOS BIOLOGY

The VIZIER project: Preparedness against pathogenic RNA viruses

(2007) B. Coutard et al.   ANTIVIRAL RESEARCH