Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation

The nf-core framework for community-curated bioinformatics pipelines

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The Number and Position of Orai3 Units within Heteromeric Store-Operated Ca2+ Channels Alter the Pharmacology of ICRAC

(2020) Sven Kappel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential regulation of Ca2+ influx by ORAI channels mediates enamel mineralization

(2019) Miriam Eckstein et al.   Science Signaling

Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection

(2018) Jessy Hasna et al.   CELL DEATH AND DIFFERENTIATION

Regulation of miR-181a expression in T cell aging

(2018) Zhongde Ye et al.   Nature Communications

Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients

(2018) Matthew T. Patrick et al.   Nature Communications

The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma

(2017) Katia Georgopoulos   GENES & DEVELOPMENT

Orai1 and Orai3 Mediate Store-Operated Calcium Entry Contributing to Neuronal Excitability in Dorsal Root Ganglion Neurons

(2017) Dongyu Wei et al.   Frontiers in Cellular Neuroscience

Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants

(2017) Lam C. Tsoi et al.   Nature Communications

Orai1 and Orai3 in Combination with Stim1 Mediate the Majority of Store-operated Calcium Entry in Astrocytes

(2017) Jea Kwon et al.   Experimental Neurobiology

T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections

(2016) Daniel T. Utzschneider et al.   IMMUNITY

Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis

(2016) Yinyin Li et al.   IMMUNITY

Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells

(2016) Judith F. Ashouri et al.   JOURNAL OF IMMUNOLOGY

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma

(2016) Nazim Benzerdjeb et al.   Oncotarget

Facilitation of Orai3 targeting and store-operated function by Orai1

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Differential Redox Regulation of Ca2+ Signaling and Viability in Normal and Malignant Prostate Cells

(2015) Christian Holzmann et al.   BIOPHYSICAL JOURNAL

CD4 + T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion

(2015) Francois P. Legoux et al.   IMMUNITY

Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8+ T Lymphocytes

(2015) Wong Yu et al.   IMMUNITY

Mechanisms of human autoimmunity

(2015) Michael D. Rosenblum et al.   JOURNAL OF CLINICAL INVESTIGATION

The Contained Self-Reactive Peripheral T Cell Repertoire: Size, Diversity, and Cellular Composition

(2015) David M. Richards et al.   JOURNAL OF IMMUNOLOGY

Ratiometric Analysis of Fura Red by Flow Cytometry: A Technique for Monitoring Intracellular Calcium Flux in Primary Cell Subsets

(2015) Emily R. Wendt et al.   PLoS One

Remodeling of Channel-Forming ORAI Proteins Determines an Oncogenic Switch in Prostate Cancer

(2014) Charlotte Dubois et al.   CANCER CELL

Transcription factor Ikaros Represses Protein Phosphatase 2A (PP2A) Expression through an Intronic Binding Site

(2014) Kamalpreet Nagpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PP2A Dephosphorylates Elf-1 and Determines the Expression of CD3  and FcR  in Human Systemic Lupus Erythematosus T Cells

(2014) Y.-T. Juang et al.   JOURNAL OF IMMUNOLOGY

PTPN22: the archetypal non-HLA autoimmunity gene

(2014) Stephanie M. Stanford et al.   Nature Reviews Rheumatology

Detection of self-reactive CD8+T cells with an anergic phenotype in healthy individuals

(2014) Yuka Maeda et al.   SCIENCE

Transcriptional regulation of the Ikzf1 locus

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Store-Independent Orai1/3 Channels Activated by Intracrine LeukotrieneC 4

(2013) José C. González-Cobos et al.   CIRCULATION RESEARCH

Orai3 Constitutes a Native Store-Operated Calcium Entry That Regulates Non Small Cell Lung Adenocarcinoma Cell Proliferation

(2013) Anne-Sophie Ay et al.   PLoS One

Tolerance and exhaustion: defining mechanisms of T cell dysfunction

(2013) Andrea Schietinger et al.   TRENDS IN IMMUNOLOGY

Predicting the Risk of Rheumatoid Arthritis and Its Age of Onset through Modelling Genetic Risk Variants with Smoking

(2013) Ian C. Scott et al.   PLoS Genetics

ORAI3 silencing alters cell proliferation and cell cycle progression via c-myc pathway in breast cancer cells

(2012) Malika Faouzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Removing technical variability in RNA-seq data using conditional quantile normalization

(2012) K. D. Hansen et al.   BIOSTATISTICS

Orai3 is an estrogen receptor α-regulated Ca2+ channel that promotes tumorigenesis

(2012) Rajender K. Motiani et al.   FASEB JOURNAL

Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

(2012) Xiaoshan Shi et al.   NATURE

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

(2012) Steve Eyre et al.   NATURE GENETICS

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus

(2011) Deborah S. Cunninghame Graham et al.   PLoS Genetics

The N-terminal domain of Orai3 determines selectivity for activation of the store-independent ARC channel by arachidonic acid

(2010) Jill Thompson et al.   Channels

Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1

(2010) Xinyuan Zhou et al.   IMMUNITY

A Novel Native Store-operated Calcium Channel Encoded by Orai3

(2010) Rajender K. Motiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

Autocrine regulation of T-cell activation by ATP release and P2X7 receptors

(2009) Linda Yip et al.   FASEB JOURNAL

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

The molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits

(2009) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanisms maintaining peripheral tolerance

(2009) Daniel L Mueller   NATURE IMMUNOLOGY

Deletion ofIKZF1and Prognosis in Acute Lymphoblastic Leukemia

(2009) Charles G. Mullighan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

(2008) Riina M. Luik et al.   NATURE

Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels

(2007) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON