Rapid Detection and Signaling of DNA Damage by PARP-1

ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells

(2021) Priyanka Verma et al.   NATURE CELL BIOLOGY

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition

(2021) Tom E H Ogden et al.   NUCLEIC ACIDS RESEARCH

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation

(2020) Marcin J. Suskiewicz et al.   NATURE

Structural basis for allosteric PARP-1 retention on DNA breaks

(2020) Levani Zandarashvili et al.   SCIENCE

Therapeutic Strategies and Biomarkers to Modulate PARP Activity for Targeted Cancer Therapy

(2020) Naveen Singh et al.   Cancers

Role of Poly (ADP-Ribose) Polymerase inhibitors beyond BReast CAncer Gene-mutated ovarian tumours: definition of homologous recombination deficiency?

(2020) Charlie Gourley et al.   CURRENT OPINION IN ONCOLOGY

Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin

(2020) Silvija Bilokapic et al.   NATURE

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo

(2020) Zhengping Shao et al.   NUCLEIC ACIDS RESEARCH

The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks

(2020) Charlotte Blessing et al.   MOLECULAR CELL

The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment

(2020) Szilvia Juhász et al.   Science Advances

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins

(2019) Elizaveta E Alemasova et al.   NUCLEIC ACIDS RESEARCH

An advanced strategy for comprehensive profiling of ADP-ribosylation sites using mass spectrometry-based proteomics

(2019) Ivo A Hendriks et al.   MOLECULAR & CELLULAR PROTEOMICS

Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation

(2018) Gabriella Zarkovic et al.   NUCLEIC ACIDS RESEARCH

Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors

(2018) Guang Yang et al.   NUCLEIC ACIDS RESEARCH

NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

(2018) Marie-France Langelier et al.   Nature Communications

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

(2018) George E. Ronson et al.   Nature Communications

Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation

(2018) Marcel Naumann et al.   Nature Communications

Serine is the major residue for ADP-ribosylation upon DNA damage

(2018) Luca Palazzo et al.   eLife

PARP2 mediates branched poly ADP-ribosylation in response to DNA damage

(2018) Qian Chen et al.   Nature Communications

Reversible mono-ADP-ribosylation of DNA breaks

(2017) Deeksha Munnur et al.   FEBS Journal

SERious Surprises for ADP-Ribosylation Specificity: HPF1 Switches PARP1 Specificity to Ser Residues

(2017) Anthony K.L. Leung   MOLECULAR CELL

Serine ADP-Ribosylation Depends on HPF1

(2017) Juan José Bonfiglio et al.   MOLECULAR CELL

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TRF2 binds branched DNA to safeguard telomere integrity

(2017) Isabelle Schmutz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The role of poly ADP-ribosylation in the first wave of DNA damage response

(2017) Chao Liu et al.   NUCLEIC ACIDS RESEARCH

Poly(ADP-ribose)polymerase-1 hyperactivation in neurodegenerative diseases: The death knell tolls for neurons

(2017) Parimala Narne et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

TRF2 binds branched DNA to safeguard telomere integrity

(2017) Isabelle Schmutz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Serine ADP-ribosylation reversal by the hydrolase ARH3

(2017) Pietro Fontana et al.   eLife

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity

(2016) Ian Gibbs-Seymour et al.   MOLECULAR CELL

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

(2016) Y. Pommier et al.   Science Translational Medicine

Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs

(2015) Jean-Philippe Gagné et al.   DNA REPAIR

Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair

(2015) Si Xie et al.   MOLECULAR CELL

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1

(2015) Sebastian Eustermann et al.   MOLECULAR CELL

PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain

(2015) Jennine M. Dawicki-McKenna et al.   MOLECULAR CELL

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage

(2015) Amanda A. Riccio et al.   NUCLEIC ACIDS RESEARCH

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function

(2015) Claire Breslin et al.   NUCLEIC ACIDS RESEARCH

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

(2015) Matthias Altmeyer et al.   Nature Communications

Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers

(2014) T Golan et al.   BRITISH JOURNAL OF CANCER

PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1

(2014) Marie-France Langelier et al.   NUCLEIC ACIDS RESEARCH

Family-wide analysis of poly(ADP-ribose) polymerase activity

(2014) Sejal Vyas et al.   Nature Communications

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis

(2013) Marie-France Langelier et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease

(2013) Reza Sharifi et al.   EMBO JOURNAL

The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response

(2013) M. Li et al.   GENES & DEVELOPMENT

Mapping PARP-1 Auto-ADP-ribosylation Sites by Liquid Chromatography–Tandem Mass Spectrometry

(2013) John D Chapman et al.   JOURNAL OF PROTEOME RESEARCH

Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities

(2013) Eva Barkauskaite et al.   Nature Communications

Advances in using PARP inhibitors to treat cancer

(2012) Shivaani Kummar et al.   BMC Medicine

Differential anti-proliferative activities of poly(ADP-ribose) polymerase (PARP) inhibitors in triple-negative breast cancer cells

(2012) Hsiao-Ching Chuang et al.   BREAST CANCER RESEARCH AND TREATMENT

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

(2012) M.-F. Langelier et al.   SCIENCE

Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA

(2011) Marie-France Langelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

(2011) Stuart L. Rulten et al.   MOLECULAR CELL

Deletion of the nuclear isoform of poly(ADP-ribose) glycohydrolase (PARG) reveals its function in DNA repair, genomic stability and tumorigenesis

(2010) W. Min et al.   CARCINOGENESIS

The Zn3 Domain of Human Poly(ADP-ribose) Polymerase-1 (PARP-1) Functions in Both DNA-dependent Poly(ADP-ribose) Synthesis Activity and Chromatin Compaction

(2010) Marie-France Langelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Biophysical Studies of Human PARP-1 in Complex with Damaged DNA

(2009) Wayne Lilyestrom et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of the ADP-Ribosylation Sites in the PARP-1 Automodification Domain: Analysis and Implications

(2009) Zhihua Tao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler

(2009) A. J. Gottschalk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

(2009) D. Ahel et al.   SCIENCE