Gut-microbiota-directed strategies to treat epilepsy: clinical and experimental evidence

Probiotics and Nigella sativa extract supplementation improved behavioral and electrophysiological effects of PTZ-induced chemical kindling in rats

(2020) Saeed Tahmasebi et al.   EPILEPSY & BEHAVIOR

The progress of gut microbiome research related to brain disorders

(2020) Sibo Zhu et al.   Journal of Neuroinflammation

Focal seizures with a migrating aspect in infants treated with beta-lactam antibiotics – Report of two cases

(2020) Kien Minh Nguyen et al.   NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY

Gut microbiota composition alterations are associated with the onset of diabetes in kidney transplant recipients

(2020) Marie Lecronier et al.   PLoS One

Alpha-Lactalbumin Enriched Whey Protein Concentrate to Improve Gut, Immunity and Brain Development in Preterm Pigs

(2020) Charlotte Holme Nielsen et al.   Nutrients

Diversity, compositional and functional differences between gut microbiota of children and adults

(2020) Djawad Radjabzadeh et al.   Scientific Reports

Molecular changes evoked by the beta-lactam antibiotic ceftriaxone across rodent models of substance use disorder and neurological disease

(2020) Irena Smaga et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Multiple areas of the cerebral cortex influence the stomach

(2020) David J. Levinthal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neohesperidin attenuates obesity by altering the composition of the gut microbiota in high‐fat diet‐fed mice

(2020) Jun Feng Lu et al.   FASEB JOURNAL

Gut–Brain Axis and Neurodegeneration: State-of-the-Art of Meta-Omics Sciences for Microbiota Characterization

(2020) Bruno Tilocca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of microbiota transplantation and the role of the vagus nerve in gut–brain axis in animals subjected to chronic mild stress

(2020) Pricila Romão Marcondes Ávila et al.   JOURNAL OF AFFECTIVE DISORDERS

Non-pharmacological Interventions for Intractable Epilepsy

(2020) Faleh Alqahtani et al.   SAUDI PHARMACEUTICAL JOURNAL

Non-malarial febrile illness: a systematic review of published aetiological studies and case reports from Southern Asia and South-eastern Asia, 1980–2015

(2020) Poojan Shrestha et al.   BMC Medicine

Ingestion of Lactobacillus intestinalis and Lactobacillus reuteri causes depression- and anhedonia-like phenotypes in antibiotic-treated mice via the vagus nerve

(2020) Siming Wang et al.   Journal of Neuroinflammation

Antibiotic-induced epileptic seizures: mechanisms of action and clinical considerations

(2020) Pitchaya Wanleenuwat et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma

(2020) Gianluca Ianiro et al.   Nature Communications

Gut microbiota modulation by both Lactobacillus fermentum MSK 408 and ketogenic diet in a murine model of pentylenetetrazole-induced acute seizure

(2020) Ju Young Eor et al.   EPILEPSY RESEARCH

Gut Bacterial Dysbiosis in Children with Intractable Epilepsy

(2020) Kihyun Lee et al.   Journal of Clinical Medicine

Systematic evaluation of rationally chosen multitargeted drug combinations: a combination of low doses of levetiracetam, atorvastatin and ceftriaxone exerts antiepileptogenic effects in a mouse model of acquired epilepsy

(2020) Lisa Welzel et al.   NEUROBIOLOGY OF DISEASE

Host-microbiota interactions: from holobiont theory to analysis

(2019) Jean-Christophe Simon et al.   Microbiome

The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy

(2019) Marie Lindefeldt et al.   npj Biofilms and Microbiomes

Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males

(2019) Maartje C. P. Cleophas et al.   Scientific Reports

Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

(2019) Qianquan Ma et al.   Journal of Neuroinflammation

The role of short-chain fatty acids in microbiota–gut–brain communication

(2019) Boushra Dalile et al.   Nature Reviews Gastroenterology & Hepatology

Effect of probiotic supplementation on seizure activity and cognitive performance in PTZ-induced chemical kindling

(2019) Samaneh Bagheri et al.   EPILEPSY & BEHAVIOR

Microbiota-gut brain axis involvement in neuropsychiatric disorders

(2019) Luigi Francesco Iannone et al.   Expert Review of Neurotherapeutics

Effects of Histone Deacetylase Inhibitors on the Development of Epilepsy and Psychiatric Comorbidity in WAG/Rij Rats

(2019) Rita Citraro et al.   MOLECULAR NEUROBIOLOGY

Changes in tryptophan and kynurenine pathway metabolites in the blood of children treated with ketogenic diet for refractory epilepsy

(2019) Iwona Żarnowska et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

The gut microbiome and epilepsy

(2019) Maria Dahlin et al.   EBioMedicine

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

The gut microbiome in neurological disorders

(2019) John F Cryan et al.   LANCET NEUROLOGY

Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy

(2019) Carmen De Caro et al.   Scientific Reports

The gut microbiome in epilepsy

(2019) Birol Şafak et al.   MICROBIAL PATHOGENESIS

Can we ‘seize’ the gut microbiota to treat epilepsy?

(2019) Carmen De Caro et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Advancing functional and translational microbiome research using meta-omics approaches

(2019) Xu Zhang et al.   Microbiome

Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?

(2018) Carolina Pellegrini et al.   ACTA NEUROPATHOLOGICA

Cephalosporin antibiotics are weak blockers of GABAa receptor-mediated synaptic transmission in rat brain slices

(2018) Dmitry V. Amakhin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neonatal seizures and white matter injury: Role of rotavirus infection and probiotics

(2018) Jung Sook Yeom et al.   BRAIN & DEVELOPMENT

Ketogenic diet attenuates neuronal injury via autophagy and mitochondrial pathways in pentylenetetrazol-kindled seizures

(2018) Bao-Hui Wang et al.   BRAIN RESEARCH

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet

(2018) Christine A. Olson et al.   CELL

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Gut Bacteria Seize Control of the Brain to Prevent Epilepsy

(2018) Sean W. Dooling et al.   Cell Host & Microbe

Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet

(2018) Yunjian Zhang et al.   EPILEPSY RESEARCH

Antibiotic and Modulation of Microbiota

(2018) Gianenrico Rizzatti et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Can epilepsy be treated by antibiotics?

(2018) Hilde M. H. Braakman et al.   JOURNAL OF NEUROLOGY

Best practices for analysing microbiomes

(2018) Rob Knight et al.   NATURE REVIEWS MICROBIOLOGY

Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs

(2018) Zhibin Chen et al.   JAMA Neurology

Rifampicin ameliorates lithium-pilocarpine-induced seizures, consequent hippocampal damage and memory deficit in rats: Impact on oxidative, inflammatory and apoptotic machineries

(2018) Alaa E. Ali et al.   BIOCHEMICAL PHARMACOLOGY

Altered composition of the gut microbiome in patients with drug-resistant epilepsy

(2018) Anjiao Peng et al.   EPILEPSY RESEARCH

You are what you eat: diet, health and the gut microbiota

(2018) Niv Zmora et al.   Nature Reviews Gastroenterology & Hepatology

The vagus afferent network: emerging role in translational connectomics

(2018) Laureen D. Hachem et al.   Neurosurgical Focus

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

The beneficial effect of probiotics as a supplementary treatment in drug-resistant epilepsy: a pilot study

(2018) M. Gómez-Eguílaz et al.   Beneficial Microbes

Microbiome–microglia connections via the gut–brain axis

(2018) Reem Abdel-Haq et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gut microbiota diversity across ethnicities in the United States

(2018) Andrew W. Brooks et al.   PLOS BIOLOGY

Effects of oral antibiotics and isotretinoin on the murine gut microbiota

(2017) Eugenia Becker et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Complications associated with antibiotic administration: neurological adverse events and interference with antiepileptic drugs

(2017) Susanna Esposito et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Microbial metabolites in health and disease: Navigating the unknown in search of function

(2017) Kristina B. Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between the microbiota, immune and nervous systems in health and disease

(2017) Thomas C Fung et al.   NATURE NEUROSCIENCE

Fecal microbiota transplantation cured epilepsy in a case with Crohn’s disease: The first report

(2017) Zhi He et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy

(2017) Gan Xie et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The Central Nervous System and the Gut Microbiome

(2016) Gil Sharon et al.   CELL

Effects of bile acids on neurological function and disease

(2016) Matthew McMillin et al.   FASEB JOURNAL

The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?

(2016) Roman M. Stilling et al.   NEUROCHEMISTRY INTERNATIONAL

A healthy gastrointestinal microbiome is dependent on dietary diversity

(2016) Mark L. Heiman et al.   Molecular Metabolism

Farnesoid X receptor: a master regulator of hepatic triglyceride and glucose homeostasis

(2014) Yang Jiao et al.   ACTA PHARMACOLOGICA SINICA

Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy

(2014) Wei Xie et al.   Journal of Neuroinflammation

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

(2014) Colin Hill et al.   Nature Reviews Gastroenterology & Hepatology

Can we predict a favourable response to Ketogenic Diet Therapies for drug-resistant epilepsy?

(2013) Natasha E. Schoeler et al.   EPILEPSY RESEARCH

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

The effect of minocycline on seizures induced by amygdala kindling in rats

(2013) Seyed Mehdi Beheshti Nasr et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Psychoactive bacteria Lactobacillus rhamnosus (JB-1) elicits rapid frequency facilitation in vagal afferents

(2012) Azucena Perez-Burgos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Minocycline- and tetracycline-class antibiotics are protective against partial seizures in vivo

(2012) Doris D. Wang et al.   EPILEPSY & BEHAVIOR

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis

(2012) E. Russo et al.   NEUROSCIENCE

Minocycline as potent anticonvulsant in a patient with astrocytoma and drug resistant epilepsy

(2012) M. Nowak et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy

(2011) Rita Citraro et al.   EPILEPSY RESEARCH

Fecal microbiota transplantation and emerging applications

(2011) Thomas J. Borody et al.   Nature Reviews Gastroenterology & Hepatology

Long-term impacts of antibiotic exposure on the human intestinal microbiota

(2010) C. Jernberg et al.   MICROBIOLOGY-SGM

ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation

(2010) Y.-J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contributions of peripheral inflammation to seizure susceptibility: Cytokines and brain excitability

(2009) Kiarash Riazi et al.   EPILEPSY RESEARCH

Microglial activation and TNF  production mediate altered CNS excitability following peripheral inflammation

(2008) K. Riazi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA