Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation

The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a

(2020) Alix A. J. Rouault et al.   Science Signaling

Metabolic insights from a GHSR-A203E mutant mouse model

(2020) Lola J. Torz et al.   Molecular Metabolism

The Role of Ghrelin in Regulating Synaptic Function and Plasticity of Feeding-Associated Circuits

(2019) Débora Serrenho et al.   Frontiers in Cellular Neuroscience

LEAP2 changes with body mass and food intake in humans and mice

(2019) Bharath K. Mani et al.   JOURNAL OF CLINICAL INVESTIGATION

Endocrine effects of the novel ghrelin receptor inverse agonist PF-5190457: Results from a placebo-controlled human laboratory alcohol co-administration study in heavy drinkers

(2019) Mary R. Lee et al.   NEUROPHARMACOLOGY

Growth hormone secretagogue receptor signalling affects high‐fat intake independently of plasma levels of ghrelin and LEAP 2, in a 4‐day binge eating model

(2019) María Paula Cornejo et al.   JOURNAL OF NEUROENDOCRINOLOGY

LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor

(2018) Xuecai Ge et al.   Cell Metabolism

The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study

(2018) Mary R. Lee et al.   MOLECULAR PSYCHIATRY

Blocking constitutive activity of GHSR1a in the lateral amygdala facilitates acquisition of conditioned taste aversion

(2018) Nan Li et al.   NEUROPEPTIDES

GHSR constitutive activity impairs voltage-gated calcium channel (CaV )-dependent inhibitory neurotransmission in hippocampal neurons

(2018) Martínez Damonte Valentina et al.   JOURNAL OF PHYSIOLOGY-LONDON

N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor

(2018) Céline M’Kadmi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Clarifying the Ghrelin System’s Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand

(2017) Alexander Edwards et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Is Ghrelin Synthesized in the Central Nervous System?

(2017) Agustina Cabral et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Constitutive activity of the Ghrelin receptor reduces surface expression of voltage-gated Ca2+channels in a CaVβ-dependent manner

(2017) Emilio R. Mustafá et al.   JOURNAL OF CELL SCIENCE

Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor

(2015) Andras Kern et al.   CELL

Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons

(2015) Eduardo Javier López Soto et al.   JOURNAL OF GENERAL PHYSIOLOGY

Costimulation of AMPA and Metabotropic Glutamate Receptors Underlies Phospholipase C Activation by Glutamate in Hippocampus

(2015) H.-H. Kim et al.   JOURNAL OF NEUROSCIENCE

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex

(2015) Marjorie Damian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways

(2015) Ted M Hsu et al.   eLife

Identification, Optimization, and Pharmacology of Acylurea GHS-R1a Inverse Agonists

(2014) William McCoull et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Central Nervous System Sites Mediating the Orexigenic Actions of Ghrelin

(2013) B.L. Mason et al.   Annual Review of Physiology

A ghrelin–growth hormone axis drives stress-induced vulnerability to enhanced fear

(2013) R M Meyer et al.   MOLECULAR PSYCHIATRY

Object recognition test in mice

(2013) Marianne Leger et al.   Nature Protocols

Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus

(2013) L. F. Ribeiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity

(2013) M. Asai et al.   SCIENCE

Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channels

(2013) Limin Shi et al.   Nature Communications

GHS-R1a constitutive activity and its physiological relevance

(2013) Yves Mear et al.   Frontiers in Neuroscience

Growth hormone secretagogue receptor (GHS-R1a) knockout mice exhibit improved spatial memory and deficits in contextual memory

(2012) Rosie G. Albarran-Zeckler et al.   BEHAVIOURAL BRAIN RESEARCH

Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt Signaling

(2012) Scott E. Kanoski et al.   BIOLOGICAL PSYCHIATRY

Contactin-associated Protein 1 (Caspr1) Regulates the Traffic and Synaptic Content of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA)-type Glutamate Receptors

(2012) Sandra D. Santos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Aromatic Region To Induce a Switch between Agonism and Inverse Agonism at the Ghrelin Receptor

(2012) Sylvia Els et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities

(2012) Ana M M Oliveira et al.   NATURE NEUROSCIENCE

Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 Agonism

(2012) Andras Kern et al.   NEURON

Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP

(2012) Mohiuddin Ahmad et al.   NEURON

High Constitutive Activity Is an Intrinsic Feature of Ghrelin Receptor Protein

(2011) Marjorie Damian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Functional Analysis of Novel Human Growth Hormone Secretagogue Receptor (GHSR) Gene Mutations in Japanese Subjects with Short Stature

(2010) Hiroshi Inoue et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin

(2010) Patricio Opazo et al.   NEURON

Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice

(2010) Jon F. Davis et al.   PHYSIOLOGY & BEHAVIOR

Behavioral profiles of three C57BL/6 substrains

(2010) Naoki Matsuo   Frontiers in Behavioral Neuroscience

In VivoCharacterization of High Basal Signaling from the Ghrelin Receptor

(2009) Pia Steen Petersen et al.   ENDOCRINOLOGY

Recessive Isolated Growth Hormone Deficiency and Mutations in the Ghrelin Receptor

(2009) Jacques Pantel et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Control of the Postsynaptic Membrane Viscosity

(2009) M. Renner et al.   JOURNAL OF NEUROSCIENCE

Effect of reducing hypothalamic ghrelin receptor gene expression on energy balance

(2009) Yogendra B. Shrestha et al.   PEPTIDES

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

(2008) Michael Lutter et al.   NATURE NEUROSCIENCE