The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a

The G-protein biased mu-opioid agonist, TRV130, produces reinforcing and antinociceptive effects that are comparable to oxycodone in rats

(2018) C. Austin Zamarripa et al.   DRUG AND ALCOHOL DEPENDENCE

Translating biased signaling in the ghrelin receptor system into differential in vivo functions

(2018) Franziska Mende et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

(2017) Thomas J. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ghrelin as a Survival Hormone

(2017) Bharath K. Mani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

MRAP2 regulates ghrelin receptor signaling and hunger sensing

(2017) Dollada Srisai et al.   Nature Communications

Biased agonism: An emerging paradigm in GPCR drug discovery

(2016) Zoran Rankovic et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity

(2016) Jong Han Lee et al.   DIABETES

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors

(2016) Cathryn Weston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1

(2016) Anna L Chaly et al.   eLife

Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2)

(2015) Cathryn Weston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GhrelinO-acyltransferase knockout mice show resistance to obesity when fed high-sucrose diet

(2015) Tetsuya Kouno et al.   JOURNAL OF ENDOCRINOLOGY

G Protein and β-Arrestin Signaling Bias at the Ghrelin Receptor

(2014) Tama Evron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minireview: More Than Just a Hammer: Ligand “Bias” and Pharmaceutical Discovery

(2014) Louis M. Luttrell   MOLECULAR ENDOCRINOLOGY

Developmental Control of the Melanocortin-4 Receptor by MRAP2 Proteins in Zebrafish

(2013) J. A. Sebag et al.   SCIENCE

Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity

(2013) M. Asai et al.   SCIENCE

Profound Hypoglycemia in Starved, Ghrelin-deficient Mice Is Caused by Decreased Gluconeogenesis and Reversed by Lactate or Fatty Acids

(2012) Robert Lin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GSK1614343, a Novel Ghrelin Receptor Antagonist, Produces an Unexpected Increase of Food Intake and Body Weight in Rodents and Dogs

(2011) Vivian J.A. Costantini et al.   NEUROENDOCRINOLOGY

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice

(2010) T.-J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of G Protein-Coupled Receptor Signaling: Specific Dominant-Negative Effects of Melanocortin 2 Receptor Accessory Protein 2

(2010) J. A. Sebag et al.   Science Signaling

Diabetic gastroparesis: Therapeutic options

(2010) Uazman Alam et al.   Diabetes Therapy