Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer?

Critical redundant functions of the adapters Grb2 and Gads in platelet (hem)ITAM signaling in mice

(2020) Timo Vögtle et al.   PLATELETS

Soluble glycoprotein VI is a predictor of major bleeding in patients with suspected heparin-induced thrombocytopenia

(2020) Allyson M. Pishko et al.   Blood Advances

Functional significance of the platelet immune receptors GPVI and CLEC-2

(2019) Julie Rayes et al.   JOURNAL OF CLINICAL INVESTIGATION

Differences and similarities in ibrutinib and acalabrutinib effects on platelet functions

(2019) Jennifer Series et al.   HAEMATOLOGICA

Adenosine and Forskolin Inhibit Platelet Aggregation by Collagen but not the Proximal Signalling Events

(2019) Joanne C. Clark et al.   THROMBOSIS AND HAEMOSTASIS

Immobilized fibrinogen activates human platelets through glycoprotein VI

(2018) Pierre H Mangin et al.   HAEMATOLOGICA

Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation to GPVI

(2018) Phillip L.R. Nicolson et al.   HAEMATOLOGICA

Platelet collagen receptor Glycoprotein VI-dimer recognizes fibrinogen and fibrin through their D-domains, contributing to platelet adhesion and activation during thrombus formation

(2018) I. Induruwa et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Dimeric Glycoprotein VI Binds to Collagen but Not to Fibrin

(2018) Mariam Ebrahim et al.   THROMBOSIS AND HAEMOSTASIS

Immobilized fibrinogen activates human platelets through glycoprotein VI

(2018) Pierre H Mangin et al.   HAEMATOLOGICA

Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation to GPVI

(2018) Phillip L.R. Nicolson et al.   HAEMATOLOGICA

Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?

(2018) Alexandre Slater et al.   PLATELETS

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets

(2017) N. S. Poulter et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI

(2017) O. Elaskalani et al.   PLATELETS

Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands

(2015) Osama M. Alshehri et al.   BIOCHEMICAL JOURNAL

Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation

(2015) E. Mammadova-Bach et al.   BLOOD

Fibrin activates GPVI in human and mouse platelets

(2015) O. M. Alshehri et al.   BLOOD

Fibrillar cellular fibronectin supports efficient platelet aggregation and procoagulant activity

(2015) Eric Maurer et al.   THROMBOSIS AND HAEMOSTASIS

The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets

(2014) Craig E. Hughes et al.   BLOOD

The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice

(2012) Tanja Schönberger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood

(2012) Stephanie M. Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct and overlapping functional roles of Src family kinases in mouse platelets

(2012) S. SÉVERIN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet Glycoprotein VI Dimerization, an Active Process Inducing Receptor Competence, Is an Indicator of Platelet Reactivity

(2011) Stéphane Loyau et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

EMMPRIN (CD147/basigin) mediates platelet-monocyte interactionsin vivoand augments monocyte recruitment to the vascular wall

(2011) C. SCHULZ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Impact of glycoprotein VI and platelet adhesion on atherosclerosis—A possible role of fibronectin

(2010) Andreas Bültmann et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Convulxin Forms a Dimer in Solution and Can Bind Eight Copies of Glycoprotein VI: Implications for Platelet Activation†

(2009) Katsunori Horii et al.   BIOCHEMISTRY

Glycoprotein (GP) VI dimer as a major collagen-binding site of native platelets: direct evidence obtained with dimeric GPVI-specific Fabs

(2009) S. M. JUNG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcγRIIa and induce GPVI ectodomain shedding

(2009) Mohammad Al-Tamimi et al.   PLATELETS

EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction

(2009) Peter Seizer et al.   THROMBOSIS AND HAEMOSTASIS

Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor γ chain complex

(2008) R. RIBA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS