Jasmonate‐ and abscisic acid‐activated AaGSW1‐AaTCP15/AaORA transcriptional cascade promotes artemisinin biosynthesis in Artemisia annua

Dynamic regulation of different light intensity-modulated anthocyanin biosynthesis by BT2-TCP46-MYB1 in apple

(2020) Jian-Ping An et al.   JOURNAL OF EXPERIMENTAL BOTANY

Specialized diterpenoid metabolism in monocot crops: Biosynthesis and chemical diversity

(2020) Katherine M. Murphy et al.   PHYTOCHEMISTRY

Jasmonate promotes artemisinin biosynthesis by activating the TCP14-ORA complex in Artemisia annua

(2019) Ya-Nan Ma et al.   Science Advances

The MPK 8‐ TCP 14 pathway promotes seed germination in Arabidopsis

(2019) Wei Zhang et al.   PLANT JOURNAL

ORANGE Represses Chloroplast Biogenesis in Etiolated Arabidopsis Cotyledons via Interaction with TCP14

(2019) Tianhu Sun et al.   PLANT CELL

The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis

(2018) Qian Shen et al.   Molecular Plant

Genome-Wide Identification and Expression Profiling of the TCP Family Genes in Spike and Grain Development of Wheat (Triticum aestivum L.)

(2018) Junmin Zhao et al.   Frontiers in Plant Science

Plant-specific transcription factor LrTCP4 enhances secondary metabolite biosynthesis in Lycium ruthenicum hairy roots

(2018) Aysha Arif Chahel et al.   PLANT CELL TISSUE AND ORGAN CULTURE

AaABF3, an Abscisic Acid–Responsive Transcription Factor, Positively Regulates Artemisinin Biosynthesis in Artemisia annua

(2018) Yijun Zhong et al.   Frontiers in Plant Science

Promotion of artemisinin content in Artemisia annua by overexpression of multiple artemisinin biosynthetic pathway genes

(2017) Pu Shi et al.   PLANT CELL TISSUE AND ORGAN CULTURE

MOS1 functions closely with TCP transcription factors to modulate immunity and cell cycle in Arabidopsis

(2017) Ning Zhang et al.   PLANT JOURNAL

The TCP4 transcription factor regulates trichome cell differentiation by directly activating GLABROUS INFLORESCENCE STEMS in Arabidopsis thaliana

(2017) Batthula Vijaya Lakshmi Vadde et al.   PLANT JOURNAL

Spatial Control of Gene Expression by miR319-Regulated TCP Transcription Factors in Leaf Development

(2017) Edgardo G. Bresso et al.   PLANT PHYSIOLOGY

The heterologous expression of a chrysanthemum TCP-P transcription factor CmTCP14 suppresses organ size and delays senescence in Arabidopsis thaliana

(2017) Ting Zhang et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Interacting TCP and NLP transcription factors control plant responses to nitrate availability

(2017) Peizhu Guan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Jasmonate-responsive transcription factors regulating plant secondary metabolism

(2016) Meiliang Zhou et al.   BIOTECHNOLOGY ADVANCES

TCP factors: new kids on the signaling block

(2016) Michael Nicolas et al.   CURRENT OPINION IN PLANT BIOLOGY

RABBIT EARS regulates the transcription of TCP4 during petal development in Arabidopsis

(2016) Jing Li et al.   JOURNAL OF EXPERIMENTAL BOTANY

Transient production of artemisinin in Nicotiana benthamiana is boosted by a specific lipid transfer protein from A. annua

(2016) Bo Wang et al.   METABOLIC ENGINEERING

Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells

(2016) Karan Malhotra et al.   Molecular Plant

Synthetic biology’s first malaria drug meets market resistance

(2016) Mark Peplow   NATURE

Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence

(2016) Huiqing Zheng et al.   Nature Chemical Biology

The jasmonate-responsive AaMYC2 transcription factor positively regulates artemisinin biosynthesis inArtemisia annua

(2016) Qian Shen et al.   NEW PHYTOLOGIST

GLANDULAR TRICHOME-SPECIFIC WRKY 1 promotes artemisinin biosynthesis in Artemisia annua

(2016) Minghui Chen et al.   NEW PHYTOLOGIST

Artemisia annuamutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism

(2016) Tomasz Czechowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Recently Evolved Alternative Splice Site in the BRANCHED1a Gene Controls Potato Plant Architecture

(2015) Michael Nicolas et al.   CURRENT BIOLOGY

Multiple Levels of Regulation Determine Monoterpenoid Essential Oil Compositional Variation in the Mint Family

(2015) Amirhossein Ahkami et al.   Molecular Plant

TRICHOME AND ARTEMISININ REGULATOR 1 Is Required for Trichome Development and Artemisinin Biosynthesis in Artemisia annua

(2015) Hexin Tan et al.   Molecular Plant

A Basic Leucine Zipper Transcription Factor, AabZIP1, Connects Abscisic Acid Signaling with Artemisinin Biosynthesis in Artemisia annua

(2015) Fangyuan Zhang et al.   Molecular Plant

The Ubiquitin Receptors DA1, DAR1, and DAR2 Redundantly Regulate Endoreduplication by Modulating the Stability of TCP14/15 in Arabidopsis

(2015) Yuancheng Peng et al.   PLANT CELL

TCP15 modulates cytokinin and auxin responses during gynoecium development in Arabidopsis

(2015) Leandro E. Lucero et al.   PLANT JOURNAL

Redox-Dependent Modulation of Anthocyanin Biosynthesis by the TCP Transcription Factor TCP15 during Exposure to High Light Intensity Conditions in Arabidopsis

(2015) Ivana L. Viola et al.   PLANT PHYSIOLOGY

Identification, cloning and characterization of the tomato TCP transcription factor family

(2014) Violeta Parapunova et al.   BMC PLANT BIOLOGY

Convergent Targeting of a Common Host Protein-Network by Pathogen Effectors from Three Kingdoms of Life

(2014) Ralf Weßling et al.   Cell Host & Microbe

Genomewide analysis of TCP transcription factor gene family in Malus domestica

(2014) RUIRUI XU et al.   JOURNAL OF GENETICS

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

(2014) Chris J. Paddon et al.   NATURE REVIEWS MICROBIOLOGY

Cloning and Characterization of AabHLH1, a bHLH Transcription Factor that Positively Regulates Artemisinin Biosynthesis in Artemisia annua

(2014) Yunpeng Ji et al.   PLANT AND CELL PHYSIOLOGY

Inducing Effect of Dihydroartemisinic Acid in the Biosynthesis of Artemisinins with Cultured Cells ofArtemisia annuaby Enhancing the Expression of Genes

(2014) Jianhua Zhu et al.   TheScientificWorldJOURNAL

The physiological response of Artemisia annua L. to salt stress and salicylic acid treatment

(2014) Lin Li et al.   PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS

Arsenic, chromium and NaCl induced artemisinin biosynthesis in Artemisia annua L.: A valuable antimalarial plant

(2013) Shilpi Paul et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Analysis of functional redundancies within the Arabidopsis TCP transcription factor family

(2013) Selahattin Danisman et al.   JOURNAL OF EXPERIMENTAL BOTANY

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

AaORA, a trichome-specific AP2/ERF transcription factor ofArtemisia annua, is a positive regulator in the artemisinin biosynthetic pathway and in disease resistance toBotrytis cinerea

(2013) Xu Lu et al.   NEW PHYTOLOGIST

TCP3 interacts with R2R3-MYB proteins, promotes flavonoid biosynthesis and negatively regulates the auxin response inArabidopsis thaliana

(2013) Shutian Li et al.   PLANT JOURNAL

The stacked over-expression of FPS, CYP71AV1 and CPR genes leads to the increase of artemisinin level in Artemisia annua L.

(2012) Yunfei Chen et al.   Plant Biotechnology Reports

The Arabidopsis O-Linked N-Acetylglucosamine Transferase SPINDLY Interacts with Class I TCPs to Facilitate Cytokinin Responses in Leaves and Flowers

(2012) E. Steiner et al.   PLANT CELL

Arabidopsis Class I and Class II TCP Transcription Factors Regulate Jasmonic Acid Metabolism and Leaf Development Antagonistically

(2012) S. Danisman et al.   PLANT PHYSIOLOGY

Antiproliferative effects of artemisinin on human breast cancer cells requires the downregulated expression of the E2F1 transcription factor and loss of E2F1-target cell cycle genes

(2011) Antony S. Tin et al.   ANTI-CANCER DRUGS

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

(2011) Maria P. Crespo-Ortiz et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Arabidopsis thaliana DOF6 negatively affects germination in non-after-ripened seeds and interacts with TCP14

(2011) Paloma Rueda-Romero et al.   JOURNAL OF EXPERIMENTAL BOTANY

The Jasmonate-Responsive AP2/ERF Transcription Factors AaERF1 and AaERF2 Positively Regulate Artemisinin Biosynthesis in Artemisia annua L.

(2011) Zong-Xia Yu et al.   Molecular Plant

HMMER web server: interactive sequence similarity searching

(2011) R. D. Finn et al.   NUCLEIC ACIDS RESEARCH

Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis

(2011) Rong Liu et al.   Parasites & Vectors

TCP14 and TCP15 affect internode length and leaf shape in Arabidopsis

(2011) Martin Kieffer et al.   PLANT JOURNAL

Trichome isolation with and without fixation using laser microdissection and pressure catapulting followed by RNA amplification: Expression of genes of terpene metabolism in apical and sub-apical trichome cells of Artemisia annua L.

(2011) Linda Olofsson et al.   PLANT SCIENCE

Dissection of the phytohormonal regulation of trichome formation and biosynthesis of the antimalarial compound artemisinin in Artemisia annua plants

(2010) Lies Maes et al.   NEW PHYTOLOGIST

Identification of Specific DNA Binding Residues in the TCP Family of Transcription Factors inArabidopsis

(2010) Pooja Aggarwal et al.   PLANT CELL

The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

(2010) I. A. Graham et al.   SCIENCE

Abscisic acid (ABA) treatment increases artemisinin content in Artemisia annua by enhancing the expression of genes in artemisinin biosynthetic pathway

(2009) Fuyuan Jing et al.   BIOLOGIA

Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annuaThis paper is one of a selection of papers published in a Special Issue from the National Research Council of Canada – Plant Biotechnology Institute.

(2009) Keat H. Teoh et al.   Botany

Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study

(2009) Nicholas Schramek et al.   PHYTOCHEMISTRY

Isolation and Characterization of AaWRKY1, an Artemisia annua Transcription Factor that Regulates the Amorpha-4,11-diene Synthase Gene, a Key Gene of Artemisinin Biosynthesis

(2009) Dongming Ma et al.   PLANT AND CELL PHYSIOLOGY

A Functional Genomics Approach Reveals CHE as a Component of the Arabidopsis Circadian Clock

(2009) J. L. Pruneda-Paz et al.   SCIENCE

Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti-malarial drug, by hairpin-RNA-mediated gene silencing

(2008) Ling Zhang et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

The Antiviral Activities of Artemisinin and Artesunate

(2008) Thomas Efferth et al.   CLINICAL INFECTIOUS DISEASES

The Molecular Cloning of Artemisinic Aldehyde Δ11(13) Reductase and Its Role in Glandular Trichome-dependent Biosynthesis of Artemisinin inArtemisia annua

(2008) Yansheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY