Activation of Nurr1 with Amodiaquine Protected Neuron and Alleviated Neuroinflammation after Subarachnoid Hemorrhage in Rats

The transcription factor Nurr1 is upregulated in amyotrophic lateral sclerosis patients and SOD1-G93A mice

(2020) Valeria Valsecchi et al.   Disease Models & Mechanisms

Nurr1 Cd11bcre conditional knockout mice display inflammatory injury to nigrostriatal dopaminergic neurons

(2020) Jie Dong et al.   GLIA

Drug repurposing against COVID-19: focus on anticancer agents

(2020) Gennaro Ciliberto et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury

(2020) Xiaobing Long et al.   Journal of Neuroinflammation

Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease

(2020) Rhyomi C. Sellnow et al.   JOURNAL OF NEUROSCIENCE

Extracellular vesicle-mediated transfer of miR-21-5p from mesenchymal stromal cells to neurons alleviates early brain injury to improve cognitive function via the PTEN/Akt pathway after subarachnoid hemorrhage

(2020) Xiao Gao et al.   Cell Death & Disease

Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling

(2020) Toshiaki Teratani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activated WNK3 induced by intracerebral hemorrhage deteriorates brain injury maybe via WNK3/SPAK/NKCC1 pathway

(2020) Degang Wu et al.   EXPERIMENTAL NEUROLOGY

Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death

(2019) Md. Jakaria et al.   MOLECULAR NEUROBIOLOGY

A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage

(2019) Keita Kinoshita et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission

(2019) Silvia Marinelli et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

FGF-2 Attenuates Neuronal Apoptosis via FGFR3/PI3k/Akt Signaling Pathway After Subarachnoid Hemorrhage

(2019) Takeshi Okada et al.   MOLECULAR NEUROBIOLOGY

NURR1 Impairment in Multiple Sclerosis

(2019) Francesca Montarolo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats

(2019) Weilin Xu et al.   Neurotherapeutics

NURR1 deficiency is associated to ADHD-like phenotypes in mice

(2019) Francesca Montarolo et al.   Translational Psychiatry

Activation of GPR30 with G1 attenuates neuronal apoptosis via src/EGFR/stat3 signaling pathway after subarachnoid hemorrhage in male rats

(2019) Jun Peng et al.   EXPERIMENTAL NEUROLOGY

Role of microglia-neuron interactions in diabetic encephalopathy

(2018) Yuan Liu et al.   AGEING RESEARCH REVIEWS

CHOP induces apoptosis by affecting brain iron metabolism in rats with subarachnoid hemorrhage

(2018) Jun Zhao et al.   EXPERIMENTAL NEUROLOGY

Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures

(2018) Julie Dyall et al.   JOURNAL OF INFECTIOUS DISEASES

Teriflunomide Modulates Vascular Permeability and Microglial Activation after Experimental Traumatic Brain Injury

(2018) Karthik S. Prabhakara et al.   MOLECULAR THERAPY

Nurr1: A vital participant in the TLR4-NF-κB signal pathway stimulated by α-synuclein in BV-2 cells

(2018) Qian-Hang Shao et al.   NEUROPHARMACOLOGY

CD200-, CX3CL1-, and TREM2-mediated neuron-microglia interactions and their involvements in Alzheimer’s disease

(2018) Lihang Zhang et al.   REVIEWS IN THE NEUROSCIENCES

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage

(2018) S. Loppi et al.   BRAIN BEHAVIOR AND IMMUNITY

Mesencephalic astrocyte-derived neurotrophic factor affords neuroprotection to early brain injury induced by subarachnoid hemorrhage via activating Akt-dependent prosurvival pathway and defending blood–brain barrier integrity

(2018) Tao Li et al.   FASEB JOURNAL

Compensatory Expression of Nur77 and Nurr1 Regulates NF-κB–Dependent Inflammatory Signaling in Astrocytes

(2018) Katriana A. Popichak et al.   MOLECULAR PHARMACOLOGY

Systematic Review of In Vivo Animal Models of Subarachnoid Hemorrhage: Species, Standard Parameters, and Outcomes

(2018) Serge Marbacher et al.   Translational Stroke Research

Nurr1 (NR4A2) regulates Alzheimer’s disease-related pathogenesis and cognitive function in the 5XFAD mouse model

(2018) Minho Moon et al.   AGING CELL

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Cografting astrocytes improves cell therapeutic outcomes in a Parkinson’s disease model

(2017) Jae-Jin Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Thioredoxin-interacting protein links endoplasmic reticulum stress to inflammatory brain injury and apoptosis after subarachnoid haemorrhage

(2017) Qing Zhao et al.   Journal of Neuroinflammation

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

(2017) Pia Rivetti di Val Cervo et al.   NATURE BIOTECHNOLOGY

Subarachnoid Hemorrhage

(2017) Michael T. Lawton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protein SUMOylation modification and its associations with disease

(2017) Yanfang Yang et al.   Open Biology

Melatonin Alleviates Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via Suppressing Apoptosis, Inflammation, Oxidative Stress, DNA Damage, and Mitochondria Injury

(2017) Zhong Wang et al.   Translational Stroke Research

Nurr1 and PPARγ protect PC12 cells against MPP+ toxicity: involvement of selective genes, anti-inflammatory, ROS generation, and antimitochondrial impairment

(2016) Mohammad Jodeiri Farshbaf et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Neuron–Microglia Interactions in Mental Health Disorders: “For Better, and For Worse”

(2016) Eric S. Wohleb   Frontiers in Immunology

Melatonin attenuates neurogenic pulmonary edema via the regulation of inflammation and apoptosis after subarachnoid hemorrhage in rats

(2015) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease

(2015) Chun-Hyung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NR4A receptors up-regulate the antiproteinase alpha-2 macroglobulin (A2M) and modulate MMP-2 and MMP-9 in vascular smooth muscle cells

(2015) Ricardo Rodríguez-Calvo et al.   THROMBOSIS AND HAEMOSTASIS

Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation

(2015) Ben J. E. Raveney et al.   Nature Communications

Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFAD mice, an animal model of Alzheimer's disease

(2014) Minho Moon et al.   JOURNAL OF NEUROCHEMISTRY

Neuronal SUMOylation: Mechanisms, Physiology, and Roles in Neuronal Dysfunction

(2014) Jeremy M. Henley et al.   PHYSIOLOGICAL REVIEWS

The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death

(2013) Shuxi Qiao et al.   Autophagy

The nuclear factor- B pathway is involved in matrix metalloproteinase-9 expression in RU486-induced endometrium breakdown in mice

(2012) Y.-F. Li et al.   HUMAN REPRODUCTION

Retinoid X receptors: common heterodimerization partners with distinct functions

(2010) Philippe Lefebvre et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Hemin toxicity: a preventable source of brain damage following hemorrhagic stroke

(2009) Stephen R. Robinson et al.   REDOX REPORT

A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model

(2007) Takashi Sugawara et al.   JOURNAL OF NEUROSCIENCE METHODS