Extracellular vesicle-mediated transfer of miR-21-5p from mesenchymal stromal cells to neurons alleviates early brain injury to improve cognitive function via the PTEN/Akt pathway after subarachnoid hemorrhage

Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch

(2019) Wenchao Liu et al.   Journal of Neuroinflammation

Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury

(2019) Zheng Gang Zhang et al.   Nature Reviews Neurology

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

MicroRNA-26b/PTEN Signaling Pathway Mediates Glycine-Induced Neuroprotection in SAH Injury

(2019) Xingping Qin et al.   NEUROCHEMICAL RESEARCH

Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice

(2018) Guo-Hong Cui et al.   FASEB JOURNAL

Intranasal Stem Cell Treatment as a Novel Therapy for Subarachnoid Hemorrhage

(2018) Cora H. Nijboer et al.   STEM CELLS AND DEVELOPMENT

Dissecting the role of miR-21 in different types of stroke

(2018) Mani Panagal et al.   GENE

miRNA expression profiling of cerebrospinal fluid in patients with aneurysmal subarachnoid hemorrhage

(2017) Stanley S. Stylli et al.   JOURNAL OF NEUROSURGERY

Spontaneous subarachnoid haemorrhage

(2017) R Loch Macdonald et al.   LANCET

MicroRNA Changes in Cerebrospinal Fluid After Subarachnoid Hemorrhage

(2017) Søren Bache et al.   STROKE

MicroRNA-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

(2017) Hongqi Xin et al.   STROKE

Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway

(2017) Honglin Yan et al.   Cell Death & Disease

Mesenchymal stem cell-derived extracellular vesicles for kidney repair: current status and looming challenges

(2017) Arash Aghajani Nargesi et al.   Stem Cell Research & Therapy

Emerging Markers of Early Brain Injury and Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage

(2017) Fawaz Al-Mufti et al.   World Neurosurgery

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

(2017) Jialei Yang et al.   Molecular Therapy-Nucleic Acids

Neuroprotective Effects of Hydrogen Sulfide Against Early Brain Injury and Secondary Cognitive Deficits Following Subarachnoid Hemorrhage

(2016) Tong Li et al.   BRAIN PATHOLOGY

Stem and Progenitor Cell-Based Therapy of the Central Nervous System: Hopes, Hype, and Wishful Thinking

(2016) Steven A. Goldman   Cell Stem Cell

Animal Models for the Study of Subarachnoid Hemorrhage: Are We Moving Towards Increased Standardization?

(2016) Serge Marbacher   Translational Stroke Research

Predicting return to work after subarachnoid hemorrhage using the Montreal Cognitive Assessment (MoCA)

(2015) Svante Wallmark et al.   ACTA NEUROCHIRURGICA

Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy

(2015) Stella Kourembanas   Annual Review of Physiology

Mesenchymal Stem Cell-Derived Exosomes Improve the Microenvironment of Infarcted Myocardium Contributing to Angiogenesis and Anti-Inflammation

(2015) Xiaomei Teng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Administration of a PTEN inhibitor BPV(pic) attenuates early brain injury via modulating AMPA receptor subunits after subarachnoid hemorrhage in rats

(2015) Yujie Chen et al.   NEUROSCIENCE LETTERS

HucMSC-Exosome Mediated-Wnt4 Signaling Is Required for Cutaneous Wound Healing

(2015) Bin Zhang et al.   STEM CELLS

Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

(2015) Yuchen Liu et al.   Scientific Reports

Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

(2014) Claudia Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-21 in ischemia/reperfusion injury: a double-edged sword?

(2014) Xialian Xu et al.   PHYSIOLOGICAL GENOMICS

miR-21 improves the neurological outcome after traumatic brain injury in rats

(2014) Xin-Tong Ge et al.   Scientific Reports

Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models

(2014) Cheau Tan et al.   Stem Cell Research & Therapy

What is Early Brain Injury?

(2014) Hidenori Suzuki   Translational Stroke Research

Rat Endovascular Perforation Model

(2014) Fatima A. Sehba   Translational Stroke Research

Mesenchymal Stem Cells Improved the Ultrastructural Morphology of Cerebral Tissues after Subarachnoid Hemorrhage in Rats

(2014) Mohammad Ali Khalili et al.   Experimental Neurobiology

Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies

(2013) Andrew S Lee et al.   NATURE MEDICINE

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

(2013) Hongqi Xin et al.   STEM CELLS

Nasal Administration of Recombinant Osteopontin Attenuates Early Brain Injury After Subarachnoid Hemorrhage

(2013) Basak Caner Topkoru et al.   STROKE

Early Brain Injury, an Evolving Frontier in Subarachnoid Hemorrhage Research

(2013) Mutsumi Fujii et al.   Translational Stroke Research

Transition of research focus from vasospasm to early brain injury after subarachnoid hemorrhage

(2012) Basak Caner et al.   JOURNAL OF NEUROCHEMISTRY

The importance of early brain injury after subarachnoid hemorrhage

(2012) Fatima A. Sehba et al.   PROGRESS IN NEUROBIOLOGY

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

(2012) Hongqi Xin et al.   STEM CELLS

Treatment with sodium orthovanadate reduces blood-brain barrier disruption via phosphatase and tensin homolog deleted on chromosome 10 (PTEN) phosphorylation in experimental subarachnoid hemorrhage

(2011) Yu Hasegawa et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Therapeutic Benefit of Intravenous Transplantation of Mesenchymal Stem Cells After Experimental Subarachnoid Hemorrhage in Rats

(2011) Mohammad Ali Khalili et al.   Journal of Stroke & Cerebrovascular Diseases

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 Attenuates Early Brain Injury in a Perforation Model of Subarachnoid Hemorrhage in Rats

(2011) Kamil Duris et al.   STROKE

Cognitive and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage

(2010) Timour Al-Khindi et al.   STROKE

Preservation of Tropomyosin-Related Kinase B (TrkB) Signaling by Sodium Orthovanadate Attenuates Early Brain Injury After Subarachnoid Hemorrhage in Rats

(2010) Yu Hasegawa et al.   STROKE

miR-21: a small multi-faceted RNA

(2008) Anna M. Krichevsky et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model

(2007) Takashi Sugawara et al.   JOURNAL OF NEUROSCIENCE METHODS

Melatonin decreases mortality following severe subarachnoid hemorrhage

(2007) Robert E. Ayer et al.   JOURNAL OF PINEAL RESEARCH