Osteoarthritis year in review: genetics, genomics, epigenetics

Identification of differentially expressed miRNAs and mRNAs in synovial of osteoarthritis via RNA-sequencing

(2020) Yu Zhou et al.   BMC Medical Genetics

Identification and functional analysis of long non‐coding RNAs in the synovial membrane of osteoarthritis patients

(2020) Xiaolong Shui et al.   CELL BIOCHEMISTRY AND FUNCTION

RNA-seq analysis of chondrocyte transcriptome reveals genetic heterogeneity in LG/J and SM/J murine strains

(2020) X. Duan et al.   OSTEOARTHRITIS AND CARTILAGE

Microarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis

(2020) R.E. Miller et al.   OSTEOARTHRITIS AND CARTILAGE

Significant changes in synovial fluid microRNAs after high tibial osteotomy in medial compartmental knee osteoarthritis: Identification of potential prognostic biomarkers

(2020) Yoon Hae Kwak et al.   PLoS One

FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis

(2020) Kwang Il Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis

(2020) Karolina Kania et al.   Scientific Reports

Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter

(2020) Amanda Dicks et al.   Stem Cell Research & Therapy

MicroRNA-375 exacerbates knee osteoarthritis through repressing chondrocyte autophagy by targeting ATG2B

(2020) Hongxing Li et al.   Aging-US

Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk

(2020) Daniel Richard et al.   CELL

Interplay between genetics and epigenetics in osteoarthritis

(2020) Sarah J. Rice et al.   Nature Reviews Rheumatology

Suppression of circadian clock protein cryptochrome 2 promotes osteoarthritis

(2020) H. Bekki et al.   OSTEOARTHRITIS AND CARTILAGE

Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α activated fibroblast-like synoviocytes

(2020) Sampurna Chakrabarti et al.   PAIN

Inhibition of TET1 prevents the development of osteoarthritis and reveals the 5hmC landscape that orchestrates pathogenesis

(2020) Piera Smeriglio et al.   Science Translational Medicine

Genome-wide occupancy profiling reveals critical roles of FOXO1 in regulating extracellular matrix and circadian rhythm genes in human chondrocytes

(2020) Tomas Duffy et al.   Arthritis & Rheumatology

Long-chain non-coding RNA HOTAIR promotes the progression of osteoarthritis via sponging miR-20b/PTEN axis

(2020) Yingchun Chen et al.   LIFE SCIENCES

Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis

(2020) Ching-Heng Chou et al.   Scientific Reports

OATargets: a knowledge base of genes associated with osteoarthritis joint damage in animals

(2020) Jamie Soul et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of long non-coding RNAs expressed in knee and hip osteoarthritic cartilage

(2019) B. Ajekigbe et al.   OSTEOARTHRITIS AND CARTILAGE

Nature vs nurture in knee osteoarthritis – the importance of age, sex and body mass index

(2019) K. Magnusson et al.   OSTEOARTHRITIS AND CARTILAGE

Cardiometabolic polygenic risk scores and osteoarthritis outcomes: a Mendelian randomization study from the Malmӧ Diet and Cancer Study and the UK Biobank

(2019) George Hindy et al.   Arthritis & Rheumatology

Mitochondrial DNA (mtDNA) haplogroups J and H are differentially associated with the methylation status of articular cartilage: potential role in apoptosis and metabolic and developmental processes

(2019) Estefanía Cortés-Pereira et al.   Arthritis & Rheumatology

Prioritization of PLEC and GRINA as osteoarthritis risk genes through the identification and characterization of novel methylation quantitative trait loci

(2019) Sarah J. Rice et al.   Arthritis & Rheumatology

Exploration of CRISPR/Cas9-based gene editing as therapy for osteoarthritis

(2019) Lan Zhao et al.   ANNALS OF THE RHEUMATIC DISEASES

LncRNA PACER is downregulated in osteoarthritis and regulates chondrocyte apoptosis and lncRNA HOTAIR expression

(2019) Mingwei Jiang et al.   BIOSCIENCE REPORTS

A preliminary analysis of microRNA profiles in the subchondral bone between Kashin-Beck disease and primary knee osteoarthritis

(2019) Guang-Hui Zhao et al.   CLINICAL RHEUMATOLOGY

Genome‐wide microRNA screening reveals miR‐582‐5p as a mesenchymal stem cell‐specific microRNA in subchondral bone of the human knee joint

(2019) Pinger Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cellular functions of long noncoding RNAs

(2019) Run-Wen Yao et al.   NATURE CELL BIOLOGY

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development

(2019) Donghyun Kang et al.   Science Translational Medicine

Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis

(2019) Lina Fu et al.   PLOS BIOLOGY

Causal factors for knee, hip and hand osteoarthritis: a Mendelian randomization study in the UK Biobank

(2019) Thomas Funck‐Brentano et al.   Arthritis & Rheumatology

PPARγ preservation via promoter demethylation alleviates osteoarthritis in mice

(2019) Xiaobo Zhu et al.   ANNALS OF THE RHEUMATIC DISEASES

MicroRNA-107 regulates autophagy and apoptosis of osteoarthritis chondrocytes by targeting TRAF3

(2019) Xiaonan Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of the ciRS-7/miR-7 axis in the regulation of proliferation, apoptosis and inflammation of chondrocytes induced by IL-1β

(2019) Xindie Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Long noncoding RNA MALAT‐1 inhibits apoptosis and matrix metabolism disorder in interleukin‐1β‐induced inflammation in articular chondrocytes via the JNK signaling pathway

(2019) Gui‐Cheng Gao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Circular RNA expression profile of knee condyle in osteoarthritis by illumina HiSeq platform

(2019) Ke Xiao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

RNA sequencing reveals the circular RNA expression profiles of osteoarthritic synovium

(2019) Shuai Xiang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

miRNA-335-5p relieves chondrocyte inflammation by activating autophagy in osteoarthritis

(2019) Gang Zhong et al.   LIFE SCIENCES

DNA methylation regulates miR-140-5p and miR-146a expression in osteoarthritis

(2019) Ioanna Papathanasiou et al.   LIFE SCIENCES

Defective WNT signaling may protect from articular cartilage deterioration – a quantitative MRI study on subjects with a heterozygous WNT1 mutation

(2019) S. Lehtovirta et al.   OSTEOARTHRITIS AND CARTILAGE

Discovery and analysis of methylation quantitative trait loci (mQTLs) mapping to novel osteoarthritis genetic risk signals

(2019) S.J. Rice et al.   OSTEOARTHRITIS AND CARTILAGE

The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1β production of macrophages and aggravated synovitis in osteoarthritis

(2019) Zhenhong Ni et al.   Cell Death & Disease

Core regulatory RNA molecules identified in articular cartilage stem/progenitor cells during osteoarthritis progression

(2019) Shuai Zhang et al.   Epigenomics

Wwp2 maintains cartilage homeostasis through regulation of Adamts5

(2019) Sho Mokuda et al.   Nature Communications

The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression

(2019) Jian Huang et al.   Nature Communications

Functional testing of thousands of osteoarthritis-associated variants for regulatory activity

(2019) Jason C. Klein et al.   Nature Communications

Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

(2019) Liping Deng et al.   Nature Communications

Synovial Fluid MicroRNA-210 as a Potential Biomarker for Early Prediction of Osteoarthritis

(2019) Wen Xie et al.   Biomed Research International

The maternal and paternal effects on clinical and surgical definitions of osteoarthritis

(2019) Eirik Weldingh et al.   Arthritis & Rheumatology

Multi-pathway protective effects of microRNAs on human chondrocytes in an in vitro model of osteoarthritis

(2019) Rua Nader Al-Modawi et al.   Molecular Therapy-Nucleic Acids

Silencing lncRNA HOTAIR declines synovial inflammation and synoviocyte proliferation and promotes synoviocyte apoptosis in osteoarthritis rats by inhibiting Wnt/β-catenin signaling pathway

(2019) Tian Mao et al.   CELL CYCLE

Circ_0136474 and MMP‐13 suppressed cell proliferation by competitive binding to miR‐127‐5p in osteoarthritis

(2019) Zhao Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

LncRNA MALAT1 mediates proliferation of LPS treated-articular chondrocytes by targeting the miR-146a-PI3K/Akt/mTOR axis

(2019) Hongxi Li et al.   LIFE SCIENCES

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

Health effects associated with serum calcium concentrations: evidence from MR-PheWAS analysis in UK Biobank

(2019) A. Zhou et al.   OSTEOPOROSIS INTERNATIONAL

FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice

(2019) Liang Kuang et al.   ANNALS OF THE RHEUMATIC DISEASES

HOTAIR‐induced apoptosis is mediated by sponging miR‐130a‐3p to repress chondrocyte autophagy in knee osteoarthritis

(2019) Bin He et al.   CELL BIOLOGY INTERNATIONAL

Effects of genotype on TENS effectiveness in controlling knee pain in persons with mild to moderate osteoarthritis

(2019) Manika Govil et al.   EUROPEAN JOURNAL OF PAIN

Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation

(2019) Sukyeong Kim et al.   Nature Communications

A thyroid hormone network exists in synovial fibroblasts of rheumatoid arthritis and osteoarthritis patients

(2019) Anna-Sophia Pörings et al.   Scientific Reports

Obese osteoarthritis patients exhibit an inflammatory synovial fibroblast phenotype, which is regulated by the long non coding RNA MALAT1

(2019) Dominika E Nanus et al.   Arthritis & Rheumatology

Analysis of “old” proteins unmasks dynamic gradient of cartilage turnover in human limbs

(2019) Ming-Feng Hsueh et al.   Science Advances

Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease

(2019) Mukundan Attur et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic variants in mTOR-pathway-related genes contribute to osteoarthritis susceptibility

(2019) Zhonghua Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Plasma miR-200c-3p, miR-100-5p, and miR-1826 serve as potential diagnostic biomarkers for knee osteoarthritis

(2019) Zhen Lai et al.   MEDICINE

Osteoarthritis year in review 2019: genetics, genomics and epigenetics

(2019) L.N. Reynard et al.   OSTEOARTHRITIS AND CARTILAGE

miR-140 Attenuates the Progression of Early-Stage Osteoarthritis by Retarding Chondrocyte Senescence

(2019) Hai-bo Si et al.   Molecular Therapy-Nucleic Acids

ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease

(2019) Stefano Schivo et al.   CELLULAR SIGNALLING

Single-cell RNA-seq analysis reveals the progression of human osteoarthritis

(2018) Quanbo Ji et al.   ANNALS OF THE RHEUMATIC DISEASES

CircRNA-Cdr1as Exerts Anti-Oncogenic Functions in Bladder Cancer by Sponging MicroRNA-135a

(2018) Peng Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The potential roles of circRNAs in osteoarthritis: a coming journey to find a treasure

(2018) Hui-Zi Li et al.   BIOSCIENCE REPORTS

microRNA-206 is required for osteoarthritis development through its effect on apoptosis and autophagy of articular chondrocytes via modulating the phosphoinositide 3-kinase/protein kinase B-mTOR pathway by targeting insulin-like growth factor-1

(2018) Qian Yu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors

(2018) Yusuke Sakurai et al.   PAIN

Increased WISP1 expression in human osteoarthritic articular cartilage is epigenetically regulated and decreases cartilage matrix production

(2018) Martijn H J van den Bosch et al.   RHEUMATOLOGY

Genome-Wide Mapping of DNA Hydroxymethylation in Osteoarthritic Chondrocytes

(2015) Sarah E. B. Taylor et al.   Arthritis & Rheumatology

TET enzymes and DNA hydroxymethylation in neural development and function — How critical are they?

(2014) Mafalda Santiago et al.   GENOMICS

A Global Increase in 5-Hydroxymethylcytosine Levels Marks Osteoarthritic Chondrocytes

(2013) Sarah E. B. Taylor et al.   Arthritis & Rheumatology