Nanozyme scavenging ROS for prevention of pathologic α-synuclein transmission in Parkinson’s disease

Single‐Atom Catalysts in Catalytic Biomedicine

(2020) Huijing Xiang et al.   ADVANCED MATERIALS

Intracellular Activation of Bioorthogonal Nanozymes through Endosomal Proteolysis of the Protein Corona

(2020) Xianzhi Zhang et al.   ACS Nano

3D anisotropic photocatalytic architectures as bioactive nerve guidance conduits for peripheral neural regeneration

(2020) Zhongyang Zhang et al.   BIOMATERIALS

Oxidative stress and α-synuclein conspire in vulnerable neurons to promote Parkinson’s disease progression

(2019) Kelvin C. Luk   JOURNAL OF CLINICAL INVESTIGATION

Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer

(2019) Ruth E. Musgrove et al.   JOURNAL OF CLINICAL INVESTIGATION

Fenozyme Protects the Integrity of the Blood–Brain Barrier against Experimental Cerebral Malaria

(2019) Shuai Zhao et al.   NANO LETTERS

Protein Corona-Triggered Catalytic Inhibition of Insufficient POSS Polymer-Caged Gold Nanoparticles for Sensitive Colorimetric Detection of Metallothioneins

(2019) Yue Zhang et al.   ANALYTICAL CHEMISTRY

Ceria Nanoparticle Systems for Selective Scavenging of Mitochondrial, Intracellular, and Extracellular Reactive Oxygen Species in Parkinson's Disease

(2018) Hyek Jin Kwon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Increased Oxidative Stress Exacerbates α-Synuclein Aggregation In Vivo

(2018) Owen Scudamore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease

(2018) Donghoon Kim et al.   Nature Nanotechnology

Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

(2018) Denzil Furtado et al.   ADVANCED MATERIALS

Chiral Molecule-mediated Porous CuxO Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson’s Disease

(2018) Changlong Hao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease

(2018) Tae-In Kam et al.   SCIENCE

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

(2018) Richard Gordon et al.   Science Translational Medicine

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo

(2018) Sílvia Porta et al.   Nature Communications

Induction of Adaptive Immunity Leads to Nigrostriatal Disease Progression in MPTP Mouse Model of Parkinson’s Disease

(2017) Goutam Chandra et al.   JOURNAL OF IMMUNOLOGY

Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain

(2016) Wen Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

TDP-43 is intercellularly transmitted across axon terminals

(2015) Marisa S. Feiler et al.   JOURNAL OF CELL BIOLOGY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

(2015) Stanley B. Prusiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration

(2015) Yong-Bo Hu et al.   Translational Neurodegeneration

Electron spin resonance spectroscopy for the study of nanomaterial-mediated generation of reactive oxygen species

(2014) Weiwei He et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

(2014) Jing L Guo et al.   NATURE MEDICINE

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration

(2014) Hien T. Tran et al.   Cell Reports

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

(2013) Kiran Yanamandra et al.   NEURON

Intrinsic catalytic activity of Au nanoparticles with respect to hydrogen peroxide decomposition and superoxide scavenging

(2012) Weiwei He et al.   BIOMATERIALS

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibiting α-Synuclein Oligomerization by Stable Cell-Penetrating β-Synuclein Fragments Recovers Phenotype of Parkinson's Disease Model Flies

(2010) Ronit Shaltiel-Karyo et al.   PLoS One

No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism

(2009) Glenda Halliday et al.   MOVEMENT DISORDERS

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

(2009) Adriano Aguzzi et al.   NEURON

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE