Core Role of Hydrophobic Core of Polymeric Nanomicelle in Endosomal Escape of siRNA

Liver-Targeted siRNA Lipid Nanoparticles Treat Hepatic Cirrhosis by Dual Antifibrotic and Anti-inflammatory Activities

(2020) Jinfang Zhang et al.   ACS Nano

RNA therapeutics on the rise

(2020) Feng Wang et al.   NATURE REVIEWS DRUG DISCOVERY

ROS-Activatable siRNA-Engineered Polyplex for NIR-Triggered Synergistic Cancer Treatment

(2020) Mengjie Zhang et al.   ACS Applied Materials & Interfaces

Bioinspired exosome-like therapeutics and delivery nanoplatforms

(2020) Mei Lu et al.   BIOMATERIALS

Viral Protein‐Pseudotyped and siRNA‐Electroporated Extracellular Vesicles for Cancer Immunotherapy

(2020) Houli Liu et al.   ADVANCED FUNCTIONAL MATERIALS

Recent advances in photothermal and RNA interfering synergistic therapy

(2020) Kun Li et al.   CHINESE CHEMICAL LETTERS

Proton-driven transformable nanovaccine for cancer immunotherapy

(2020) Ningqiang Gong et al.   Nature Nanotechnology

Shear-responsive peptide/siRNA complexes as lung-targeting gene vectors

(2020) Dongxiao Yin et al.   CHINESE CHEMICAL LETTERS

A novel polyethyleneimine-decorated FeOOH nanoparticle for efficient siRNA delivery

(2020) Shuai Guo et al.   CHINESE CHEMICAL LETTERS

Carrier-free nanoassembly of doxorubicin prodrug and siRNA for combinationally inducing immunogenic cell death and reversing immunosuppression

(2020) Senbiao Chen et al.   Nano Today

Strategies and materials of "SMART" non-viral vectors: Overcoming the barriers for brain gene therapy

(2020) Yan Li et al.   Nano Today

Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle

(2020) Tongren Yang et al.   Bioactive Materials

Rolling microneedle electrode array (RoMEA) empowered nucleic acid delivery and cancer immunotherapy

(2020) Tongren Yang et al.   Nano Today

An Open‐Label, Multicenter, Phase I, Dose Escalation Study with Phase II Expansion Cohort to Determine the Safety, Pharmacokinetics, and Preliminary Antitumor Activity of Intravenous TKM‐080301 in Subjects with Advanced Hepatocellular Carcinoma

(2019) Imane El Dika et al.   ONCOLOGIST

RNAi therapeutic and its innovative biotechnological evolution

(2019) Yuhua Weng et al.   BIOTECHNOLOGY ADVANCES

Clinical advances of siRNA therapeutics

(2019) Bo Hu et al.   JOURNAL OF GENE MEDICINE

Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury

(2019) Shaowei Guo et al.   ACS Nano

Delivery of High Mobility Group Box-1 siRNA Using Brain-Targeting Exosomes for Ischemic Stroke Therapy

(2019) Minkyung Kim et al.   Journal of Biomedical Nanotechnology

Folate-displaying exosome mediated cytosolic delivery of siRNA avoiding endosome trapping

(2019) Zhen Zheng et al.   JOURNAL OF CONTROLLED RELEASE

Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression

(2018) Jennifer L.S. Willoughby et al.   MOLECULAR THERAPY

Fluorinated Oligoethylenimine Nanoassemblies for Efficient siRNA-Mediated Gene Silencing in Serum-Containing Media by Effective Endosomal Escape

(2018) Tingbin Zhang et al.   NANO LETTERS

siRNA Knockdown of RRM2 Effectively Suppressed Pancreatic Tumor Growth Alone or Synergistically with Doxorubicin

(2018) Shuquan Zheng et al.   Molecular Therapy-Nucleic Acids

Regulation of Ca2+ Signaling for Drug-Resistant Breast Cancer Therapy with Mesoporous Silica Nanocapsule Encapsulated Doxorubicin/siRNA Cocktail

(2018) Shu Wang et al.   ACS Nano

Combinatorial optimization of PEG architecture and hydrophobic content improves ternary siRNA polyplex stability, pharmacokinetics, and potency in vivo

(2017) Thomas A. Werfel et al.   JOURNAL OF CONTROLLED RELEASE

Overcoming cellular barriers for RNA therapeutics

(2017) Steven F Dowdy   NATURE BIOTECHNOLOGY

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

(2017) Fengmei Pi et al.   Nature Nanotechnology

The pH-Triggered Triblock Nanocarrier Enabled Highly Efficient siRNA Delivery for Cancer Therapy

(2017) Lili Du et al.   Theranostics

Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics

(2017) Yuanyu Huang   Molecular Therapy-Nucleic Acids

pH-Sensitive Nanomicelles for High-Efficiency siRNA Delivery in Vitro and in Vivo: An Insight into the Design of Polycations with Robust Cytosolic Release

(2016) Junhui Zhou et al.   NANO LETTERS

Non-covalent interactions in controlling pH-responsive behaviors of self-assembled nanosystems

(2016) Yang Li et al.   Polymer Chemistry

Systemic and tumor-targeted delivery of siRNA by cyclic NGR and isoDGR motif-containing peptides

(2016) Yuanyu Huang et al.   Biomaterials Science

Tuning PEGylation of mixed micelles to overcome intracellular and systemic siRNA delivery barriers

(2015) Martina Miteva et al.   BIOMATERIALS

Protease-triggered siRNA delivery vehicles

(2015) David B. Rozema et al.   JOURNAL OF CONTROLLED RELEASE

Knocking down disease: a progress report on siRNA therapeutics

(2015) Anders Wittrup et al.   NATURE REVIEWS GENETICS

Systemic Administration of siRNA via cRGD-containing Peptide

(2015) Yuanyu Huang et al.   Scientific Reports

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

Intracellular cleavable poly(2-dimethylaminoethyl methacrylate) functionalized mesoporous silica nanoparticles for efficient siRNA delivery in vitro and in vivo

(2013) Daoshu Lin et al.   Nanoscale

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Possible “Proton Sponge ” Effect of Polyethylenimine (PEI) Does Not Include Change in Lysosomal pH

(2012) Rikke V Benjaminsen et al.   MOLECULAR THERAPY

Structural contributions of blocked or grafted poly(2-dimethylaminoethyl methacrylate) on PEGylated polycaprolactone nanoparticles in siRNA delivery

(2011) Daoshu Lin et al.   BIOMATERIALS

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE