Rolling microneedle electrode array (RoMEA) empowered nucleic acid delivery and cancer immunotherapy

The challenge and prospect of mRNA therapeutics landscape

(2020) Yuhua Weng et al.   BIOTECHNOLOGY ADVANCES

Givosiran: First Approval

(2020) Lesley J. Scott   DRUGS

Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs

(2020) Jicheng Yu et al.   Nature Biomedical Engineering

RNAi therapeutic and its innovative biotechnological evolution

(2019) Yuhua Weng et al.   BIOTECHNOLOGY ADVANCES

Co-Delivery of Gemcitabine and Mcl-1 SiRNA via Cationic Liposome-Based System Enhances the Efficacy of Chemotherapy in Pancreatic Cancer

(2019) Yanbing Wang et al.   Journal of Biomedical Nanotechnology

Delivery of High Mobility Group Box-1 siRNA Using Brain-Targeting Exosomes for Ischemic Stroke Therapy

(2019) Minkyung Kim et al.   Journal of Biomedical Nanotechnology

Quantitative PET imaging of PD-L1 expression in xenograft and syngeneic tumour models using a site-specifically labelled PD-L1 antibody

(2019) Camilla Christensen et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Improved Nucleic Acid Therapy with Advanced Nanoscale Biotechnology

(2019) Yuhua Weng et al.   Molecular Therapy-Nucleic Acids

Efficient delivery of nucleic acid molecules into skin by combined use of microneedle roller and flexible interdigitated electroporation array

(2018) Dong Huang et al.   Theranostics

Reprogramming human T cell function and specificity with non-viral genome targeting

(2018) Theodore L. Roth et al.   NATURE

Trial watch: The clinical trial landscape for PD1/PDL1 immune checkpoint inhibitors

(2018) Jun Tang et al.   NATURE REVIEWS DRUG DISCOVERY

Electroformation and collection of giant liposomes on an integrated microchip

(2018) Zhenyu Wang et al.   CHINESE CHEMICAL LETTERS

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

The pH-Triggered Triblock Nanocarrier Enabled Highly Efficient siRNA Delivery for Cancer Therapy

(2017) Lili Du et al.   Theranostics

Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics

(2017) Yuanyu Huang   Molecular Therapy-Nucleic Acids

Allometric scaling of skin thickness, elasticity, viscoelasticity to mass for micro-medical device translation: from mice, rats, rabbits, pigs to humans

(2017) Jonathan C. J. Wei et al.   Scientific Reports

Gene Electrotransfer: A Mechanistic Perspective

(2016) Christelle Rosazza et al.   CURRENT GENE THERAPY

Micro-/nanoscale electroporation

(2016) Lingqian Chang et al.   LAB ON A CHIP

Pharmacokinetic Behaviors of Intravenously Administered siRNA in Glandular Tissues

(2016) Yuanyu Huang et al.   Theranostics

Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

(2015) Jicheng Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Pliable Electroporation Patch (ep-Patch) for Efficient Delivery of Nucleic Acid Molecules into Animal Tissues with Irregular Surface Shapes

(2015) Zewen Wei et al.   Scientific Reports

Electroporation-Based Technologies for Medicine: Principles, Applications, and Challenges

(2014) Martin L. Yarmush et al.   Annual Review of Biomedical Engineering

A flexible microneedle array as low-voltage electroporation electrodes for in vivo DNA and siRNA delivery

(2014) Zewen Wei et al.   LAB ON A CHIP

Targeted genome editing in human repopulating haematopoietic stem cells

(2014) Pietro Genovese et al.   NATURE

Close-Field Electroporation Gene Delivery Using the Cochlear Implant Electrode Array Enhances the Bionic Ear

(2014) J. L. Pinyon et al.   Science Translational Medicine

CTLA-4 and PD-1/PD-L1 Blockade: New Immunotherapeutic Modalities with Durable Clinical Benefit in Melanoma Patients

(2013) P. A. Ott et al.   CLINICAL CANCER RESEARCH

Tumor Immunotherapy Directed at PD-1

(2012) Antoni Ribas   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intracellular Protein Delivery and Gene Transfection by Electroporation Using a Microneedle Electrode Array

(2012) Seong-O Choi et al.   Small

Hyaluronidase and Collagenase Increase the Transfection Efficiency of Gene Electrotransfer in Various Murine Tumors

(2011) Maja Cemazar et al.   HUMAN GENE THERAPY

Prototype development and preclinical immunogenicity analysis of a novel minimally invasive electroporation device

(2010) K E Broderick et al.   GENE THERAPY

Elimination Pathways of Systemically Delivered siRNA

(2010) Yuanyu Huang et al.   MOLECULAR THERAPY

Biodistribution, persistence and lack of integration of a multigene HIV vaccine delivered by needle-free intradermal injection and electroporation

(2010) Andreas Bråve et al.   VACCINE

CpG Oligodeoxyneucleotides as TLR9 Agonists

(2009) Yanal M. Murad et al.   BIODRUGS

Electrically Mediated Delivery of Plasmid DNA to the Skin, Using a Multielectrode Array

(2009) Richard Heller et al.   HUMAN GENE THERAPY

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

(2009) Marcin Kortylewski et al.   NATURE BIOTECHNOLOGY

Skin penetration enhancement by a microneedle device (Dermaroller®) in vitro: Dependency on needle size and applied formulation

(2008) M.M. Badran et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Phase I Trial of Interleukin-12 Plasmid Electroporation in Patients With Metastatic Melanoma

(2008) Adil I. Daud et al.   JOURNAL OF CLINICAL ONCOLOGY

Transdermal drug delivery

(2008) Mark R Prausnitz et al.   NATURE BIOTECHNOLOGY