Pathogenic Roles of S100A8 and S100A9 Proteins in Acute Myeloid and Lymphoid Leukemia: Clinical and Therapeutic Impacts

Increased S100A8 expression in bone marrow plasma by monocytic cells from acute myeloid leukemia patients

(2020) Julie Mondet et al.   HEMATOLOGICAL ONCOLOGY

Roles of S100 family members in drug resistance in tumors: Status and prospects

(2020) Xin Hua et al.   BIOMEDICINE & PHARMACOTHERAPY

Contribution of Aberrant Toll Like Receptor Signaling to the Pathogenesis of Myelodysplastic Syndromes

(2020) Luana Chiquetto Paracatu et al.   Frontiers in Immunology

S100A8 and S100A9 Promote Apoptosis of Chronic Eosinophilic Leukemia Cells

(2020) Ji-Sook Lee et al.   Frontiers in Immunology

S100A9-induced overexpression of PD-1/PD-L1 contributes to ineffective hematopoiesis in myelodysplastic syndromes

(2019) Pinyang Cheng et al.   LEUKEMIA

Elevated expression of S100A8 and S100A9 correlates with resistance to the BCL-2 inhibitor venetoclax in AML

(2019) Riikka Karjalainen et al.   LEUKEMIA

Curcumin increases the sensitivity of K562/DOX cells to doxorubicin by targeting S100 calcium‑binding protein A8 and P‑glycoprotein

(2019) Liu Yang et al.   Oncology Letters

Circulating S100A8 and S100A9 protein levels in plasma of patients with acquired aplastic anemia and myelodysplastic syndromes

(2018) Valentina Giudice et al.   CYTOKINE

S100 Proteins in Acute Myeloid Leukemia

(2018) Annette K. Brenner et al.   NEOPLASIA

Gene expression profiling of acute myeloid leukemia samples from adult patients with AML-M1 and -M2 through boutique microarrays, real-time PCR and droplet digital PCR

(2017) Luiza Handschuh et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

S100A7: from mechanism to cancer therapy

(2017) L Padilla et al.   ONCOGENE

Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment

(2017) Michel Eisenblaetter et al.   Theranostics

Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion

(2017) Kim De Veirman et al.   Cancer Immunology Research

Regulatory mechanism and functional analysis of S100A9 in acute promyelocytic leukemia cells

(2017) Yonglan Zhu et al.   Frontiers of Medicine

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

(2016) A. A. Basiorka et al.   BLOOD

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia

(2016) Noemi A. Zambetti et al.   Cell Stem Cell

MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-κB and ROS formation upon ligand binding

(2016) I. Made Winarsa Ruma et al.   CLINICAL & EXPERIMENTAL METASTASIS

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9

(2016) Rebekka K Schneider et al.   NATURE MEDICINE

Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells

(2016) S Y Lim et al.   ONCOGENE

High expression of S100A8 gene is associated with drug resistance to etoposide and poor prognosis in acute myeloid leukemia through influencing the apoptosis pathway

(2016) Shao-yan Hu et al.   OncoTargets and Therapy

Network-based expression analysis reveals key genes related to glucocorticoid resistance in infant acute lymphoblastic leukemia

(2016) Zaynab Mousavian et al.   CELLULAR ONCOLOGY

Methylation of S100A8 is a promising diagnosis and prognostic marker in hepatocellular carcinoma

(2016) Kun Liu et al.   Oncotarget

Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages

(2015) Juan Wang et al.   FASEB JOURNAL

Optical In Vivo Imaging of the Alarmin S100A9 in Tumor Lesions Allows for Estimation of the Individual Malignant Potential by Evaluation of Tumor-Host Cell Interaction

(2015) A. Becker et al.   JOURNAL OF NUCLEAR MEDICINE

Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment

(2015) A Deguchi et al.   ONCOGENE

Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion

(2015) Monika Pruenster et al.   Nature Communications

Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice

(2014) Hong Qin et al.   NATURE MEDICINE

S100P antibody-mediated therapy as a new promising strategy for the treatment of pancreatic cancer

(2014) S Dakhel et al.   Oncogenesis

Mechanisms of action of tasquinimod on the tumour microenvironment

(2013) E. Raymond et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Induction of myelodysplasia by myeloid-derived suppressor cells

(2013) Xianghong Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein biomarkers distinguish between high- and low-risk pediatric acute lymphoblastic leukemia in a tissue specific manner

(2013) Maria Braoudaki et al.   Journal of Hematology & Oncology

Exosomes from Myeloid-Derived Suppressor Cells Carry Biologically Active Proteins

(2013) Meghan Burke et al.   JOURNAL OF PROTEOME RESEARCH

Relapsed childhood acute lymphoblastic leukaemia

(2013) Deepa Bhojwani et al.   LANCET ONCOLOGY

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

S100A8 and S100A9 Induce Cytokine Expression and Regulate the NLRP3 Inflammasome via ROS-Dependent Activation of NF-κB1

(2013) Jean-Christophe Simard et al.   PLoS One

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

S100A9 Is a Novel Ligand of EMMPRIN That Promotes Melanoma Metastasis

(2012) T. Hibino et al.   CANCER RESEARCH

Functions of S100 Proteins

(2012) R. Donato et al.   CURRENT MOLECULAR MEDICINE

Elevated S100A8/S100A9 expression causes glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia

(2012) J A P Spijkers-Hagelstein et al.   LEUKEMIA

S100A9 Interaction with TLR4 Promotes Tumor Growth

(2012) Eva Källberg et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Myeloid related proteins activate Toll-like receptor 4 in human acute coronary syndromes

(2011) Keiko Yonekawa et al.   ATHEROSCLEROSIS

S100A8-targeting siRNA enhances arsenic trioxide-induced myeloid leukemia cell death by down-regulating autophagy

(2011) Lizhi Cao   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML–BFM and DCOG study groups

(2011) F Damm et al.   LEUKEMIA

S100A8/A9 Activate Key Genes and Pathways in Colon Tumor Progression

(2011) M. Ichikawa et al.   MOLECULAR CANCER RESEARCH

The down regulation of neutrophil oxidative metabolism by S100A8 and S100A9: Implication of the protease-activated receptor-2

(2011) Herve Y. Sroussi et al.   MOLECULAR IMMUNOLOGY

Gene expression profiles of infant acute lymphoblastic leukaemia and its prognostically distinct subsets

(2010) Sanjive Qazi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Expression of S100A8 in leukemic cells predicts poor survival in de novo AML patients

(2010) E Nicolas et al.   LEUKEMIA

S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3

(2009) Saeid Ghavami et al.   CELL RESEARCH

S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis

(2009) Julia Németh et al.   HEPATOLOGY

S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway

(2008) S. Ghavami et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Global Gene Expression Profiling Unveils S100A8/A9 as Candidate Markers in H-Ras-Mediated Human Breast Epithelial Cell Invasion

(2008) A. Moon et al.   MOLECULAR CANCER RESEARCH

The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

(2008) Sachie Hiratsuka et al.   NATURE CELL BIOLOGY