S100A8 and S100A9 Promote Apoptosis of Chronic Eosinophilic Leukemia Cells

S100A9 Regulates MDSCs-Mediated Immune Suppression via the RAGE and TLR4 Signaling Pathways in Colorectal Carcinoma

(2019) Mao Huang et al.   Frontiers in Immunology

Presence of S100A8/Gr1-Positive Myeloid-Derived Suppressor Cells in Primary Tumors and Visceral Organs Invaded by Breast Carcinoma Cells

(2018) Gamze Tanriover et al.   Clinical Breast Cancer

Discovery of 4-(( N -(2-(dimethylamino)ethyl)acrylamido)methyl)- N -(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibitor for PDGFRα driving chronic eosinophilic leukemia

(2018) Qiang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Calprotectin and the Initiation and Progression of Head and Neck Cancer

(2018) P.P. Argyris et al.   JOURNAL OF DENTAL RESEARCH

Crucial Role of Linear Ubiquitin Chain Assembly Complex–Mediated Inhibition of Programmed Cell Death in TLR4-Mediated B Cell Responses and B1b Cell Development

(2018) Yoshiteru Sasaki et al.   JOURNAL OF IMMUNOLOGY

Chemotactic effect of S100A8 and S100A9 on human eosinophilic leukemia cells, EoL-1 through TLR4

(2018) Ayoung Gu et al.   Molecular & Cellular Toxicology

TLR4 and RAGE conversely mediate pro-inflammatory S100A8/9-mediated inhibition of proliferation-linked signaling in myeloproliferative neoplasms

(2018) Marijana Kovačić et al.   CELLULAR ONCOLOGY

S100A8/A9 in Inflammation

(2018) Siwen Wang et al.   Frontiers in Immunology

Immunological Approaches Towards Cancer and Inflammation: A Cross Talk

(2018) Xinglong Qu et al.   Frontiers in Immunology

Human Toll-Like Receptor 4 (hTLR4): Structural and functional dynamics in cancer

(2018) Vinita Mishra et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Monophosphoryl lipid a attenuates radiation injury through TLR4 activation

(2017) Jiaming Guo et al.   Oncotarget

Alarmin S100A8 Activates Alveolar Epithelial Cells in the Context of Acute Lung Injury in a TLR4-Dependent Manner

(2017) Deblina Chakraborty et al.   Frontiers in Immunology

Myeloid neoplasms with eosinophilia

(2016) Andreas Reiter et al.   BLOOD

Discovery and Structure–Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists

(2016) Matthew D. Morin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lyn mediates FIP1L1-PDGFRA signal pathway facilitating IL- 5RA intracellular signal through FIP1L1-PDGFRA/JAK2/Lyn/Akt network complex in CEL

(2016) Bin Li et al.   Oncotarget

Long-term outcomes of imatinib in patients with FIP1L1/ PDGFRA associated chronic eosinophilic leukemia: experience of a single center in China

(2016) Shi-Qiang Qu et al.   Oncotarget

S100A8+ stroma cells predict a good prognosis and inhibit aggressiveness in colorectal carcinoma

(2016) Si Li et al.   OncoImmunology

S100A9 expressed in ER−PgR− breast cancers induces inflammatory cytokines and is associated with an impaired overall survival

(2015) Caroline Bergenfelz et al.   BRITISH JOURNAL OF CANCER

F604S exchange in FIP1L1-PDGFRA enhances FIP1L1-PDGFRA protein stability via SHP-2 and SRC: a novel mode of kinase inhibitor resistance

(2015) S P Gorantla et al.   LEUKEMIA

Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment

(2015) A Deguchi et al.   ONCOGENE

House Dust Mite Allergen Regulates Constitutive Apoptosis of Normal and Asthmatic Neutrophils via Toll-Like Receptor 4

(2015) Do Hyung Kim et al.   PLoS One

Identification of Ponatinib as a potent inhibitor of growth, migration, and activation of neoplastic eosinophils carrying FIP1L1-PDGFRA

(2014) Irina Sadovnik et al.   EXPERIMENTAL HEMATOLOGY

TLR4 Ligands Lipopolysaccharide and Monophosphoryl Lipid A Differentially Regulate Effector and Memory CD8+ T Cell Differentiation

(2014) W. Cui et al.   JOURNAL OF IMMUNOLOGY

Proteomics-Based Strategies To Identify Proteins Relevant to Chronic Lymphocytic Leukemia

(2014) Suliman A. Alsagaby et al.   JOURNAL OF PROTEOME RESEARCH

Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekeeper mutant T674I FIP1L1-PDGFRα: roles of Mcl-1 and β-catenin

(2014) Yanli Jin et al.   Molecular Cancer

S100A8 Contributes to Drug Resistance by Promoting Autophagy in Leukemia Cells

(2014) Minghua Yang et al.   PLoS One

Oncostatin M is a FIP1L1/PDGFRA-dependent mediator of cytokine production in chronic eosinophilic leukemia

(2013) G. Hoermann et al.   ALLERGY

Cyclin-Dependent Kinase 7/9 Inhibitor SNS-032 Abrogates FIP1-like-1 Platelet-Derived Growth Factor Receptor   and Bcr-Abl Oncogene Addiction in Malignant Hematologic Cells

(2012) Y. Wu et al.   CLINICAL CANCER RESEARCH

Inflammation-associated S100 proteins: new mechanisms that regulate function

(2010) Jesse Goyette et al.   AMINO ACIDS

Expression of S100A8 in leukemic cells predicts poor survival in de novo AML patients

(2010) E Nicolas et al.   LEUKEMIA

Long-term exposure of leukemia cells to multi-targeted tyrosine kinase inhibitor induces activations of AKT, ERK and STAT5 signaling via epigenetic silencing of the PTEN gene

(2010) C Nishioka et al.   LEUKEMIA

Triptolide abrogates oncogene FIP1L1-PDGFRα addiction and induces apoptosis in hypereosinophilic syndrome

(2009) Yanli Jin et al.   CANCER SCIENCE