Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity

Natural and synthetic drugs used for the treatment of the dementia

(2020) Valery M. Dembitsky et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Artemisinin-derived hybrids and their anticancer activity

(2020) Feng Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin‐derived antimalarial endoperoxides from bench‐side to bed‐side: Chronological advancements and future challenges

(2020) Mohit K. Tiwari et al.   MEDICINAL RESEARCH REVIEWS

Computer-aided prediction of biological activity spectra for organic compounds: the possibilities and limitations

(2020) V. V. Poroikov et al.   RUSSIAN CHEMICAL BULLETIN

Novel secondary metabolites from endophytic fungi: synthesis and biological properties

(2020) Nigora Rustamova et al.   PHYTOCHEMISTRY REVIEWS

Global prevalence and mortality of severe Plasmodium malariae infection: a systematic review and meta-analysis

(2020) Manas Kotepui et al.   MALARIA JOURNAL

Artemisinin and its derivatives: a promising cancer therapy

(2020) Bushra Hafeez Kiani et al.   MOLECULAR BIOLOGY REPORTS

The birth of artemisinin

(2020) Nan Ma et al.   PHARMACOLOGY & THERAPEUTICS

Antitumor and hepatoprotective activity of natural and synthetic neo steroids

(2020) Valery M. Dembitsky   PROGRESS IN LIPID RESEARCH

Antimicrobial Activity of Nitrogen-Containing 5-α-Androstane Derivatives: In Silico and Experimental Studies

(2020) Lela Amiranashvili et al.   Antibiotics-Basel

Ape Origins of Human Malaria

(2020) Paul M. Sharp et al.   Annual Review of Microbiology

Pharmacological profile of natural and synthetic compounds with rigid adamantane-based scaffolds as potential agents for the treatment of neurodegenerative diseases

(2020) Valery M. Dembitsky et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The antimalarial resistome – finding new drug targets and their modes of action

(2020) Krypton Carolino et al.   CURRENT OPINION IN MICROBIOLOGY

Merging Ligand-Based and Structure-Based Methods in Drug Discovery: An Overview of Combined Virtual Screening Approaches

(2020) Javier Vázquez et al.   MOLECULES

Global research on artemisinin and its derivatives: Perspectives from patents

(2020) Kunmeng Liu et al.   PHARMACOLOGICAL RESEARCH

Advances in the research on the targets of anti-malaria actions of artemisinin

(2020) Jing Yang et al.   PHARMACOLOGY & THERAPEUTICS

Editorial: Artemisinin—From Traditional Chinese Medicine to Artemisinin Combination Therapies; Four Decades of Research on the Biochemistry, Physiology, and Breeding of Artemisia annua

(2020) Tomasz Czechowski et al.   Frontiers in Plant Science

3-Amino-5-(indol-3-yl)methylene-4-oxo-2-thioxothiazolidine Derivatives as Antimicrobial Agents: Synthesis, Computational and Biological Evaluation

(2020) Volodymyr Horishny et al.   Pharmaceuticals

Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities

(2020) Ekaterina V. Ermolenko et al.   Marine Drugs

Hydroperoxy steroids and triterpenoids derived from plant and fungi: Origin, structures and biological activities

(2019) Vera A. Vil et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Naturally occurring of α,β-diepoxy-containing compounds: origin, structures, and biological activities

(2019) Vera Vil et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Trunculins X and Y from an Okinawan sponge Sigmosceptrella sp.

(2019) Hiromi Hirade et al.   TETRAHEDRON

Evolving Concept of Activity Cliffs

(2019) Dagmar Stumpfe et al.   ACS Omega

A review of the traditional use of southern African medicinal plants for the treatment of malaria

(2019) I.E. Cock et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antiplasmodial natural products: an update

(2019) Nasir Tajuddeen et al.   MALARIA JOURNAL

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

(2019) Alejandro M. S. Mayer et al.   Marine Drugs

A literature review on traditional herbal medicines for malaria

(2019) Monica Noronha et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Peroxy steroids derived from plant and fungi and their biological activities

(2018) Vera A. Vil et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Structural diversity and biological activities of phloroglucinol derivatives from Hypericum species

(2018) Henrique Bridi et al.   PHYTOCHEMISTRY

Highly oxygenated isoprenoid lipids derived from fungi and fungal endophytes: Origin and biological activities

(2018) Nick Savidov et al.   STEROIDS

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action

(2017) Yin Kwan Wong et al.   MEDICINAL RESEARCH REVIEWS

Crinoids: ancient organisms, modern chemistry

(2017) Yunjiang Feng et al.   NATURAL PRODUCT REPORTS

Computational platform Way2Drug: from the prediction of biological activity to drug repurposing

(2017) D. S. Druzhilovskiy et al.   RUSSIAN CHEMICAL BULLETIN

Natural Endoperoxides as Drug Lead Compounds

(2016) Ming Bu et al.   CURRENT MEDICINAL CHEMISTRY

Goianone, a new natural polyprenylated benzophenone with a homo-adamantyl ketone core spiro-fused to a cyclic peroxide

(2016) C Novais et al.   PLANTA MEDICA

Ergosterol peroxide activates Foxo3-mediated cell death signaling by inhibiting AKT and c-Myc in human hepatocellular carcinoma cells

(2016) Xiangmin Li et al.   Oncotarget

Novel sesquiterpenes from Schisandra grandiflora: Isolation, cytotoxic activity and synthesis of their triazole derivatives using “click” reaction

(2015) B. Poornima et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Expeditious Entry to the Chamigrane Endoperoxide Family of Natural Products

(2015) Hui-Jun Chen et al.   ORGANIC LETTERS

Hypersubones A and B, New Polycyclic Acylphloroglucinols with Intriguing Adamantane Type Cores from Hypericum subsessile

(2015) Yang Liao et al.   ORGANIC LETTERS

Withanolides from three species of the genus Deprea (Solanaceae). Chemotaxonomical considerations

(2015) Carina N. Casero et al.   PHYTOCHEMISTRY

Target prediction utilising negative bioactivity data covering large chemical space

(2015) Lewis H. Mervin et al.   Journal of Cheminformatics

Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.

(2014) Bora Mun et al.   ARCHIVES OF PHARMACAL RESEARCH

Propargylic Sulfides: Synthesis, Properties, and Application

(2014) Svetlana A. Vizer et al.   CHEMICAL REVIEWS

Antimalarials in Development in 2014

(2014) David S. Barnett et al.   CHEMICAL REVIEWS

“Recycling” Classical Drugs for Malaria

(2014) Cátia Teixeira et al.   CHEMICAL REVIEWS

Garcimultiflorone G, a Novel Benzoylphloroglucinol Derivative fromGarcinia multiflorawith Inhibitory Activity on Neutrophil Pro-Inflammatory Responses

(2014) Chia-Wei Ting et al.   CHEMISTRY & BIODIVERSITY

Prediction of the Biological Activity Spectra of Organic Compounds Using the Pass Online Web Resource

(2014) D. A. Filimonov et al.   Chemistry of Heterocyclic Compounds

Unprecedented 1,14-seco-Crotofolanes fromCroton insularis: Oxidative Cleavage of Crotofolin C by a Putative Homo-Baeyer-Villiger Rearrangement

(2014) Lidiya A. Maslovskaya et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structural Elucidation of Humulone Autoxidation Products and Analysis of Their Occurrence in Stored Hops

(2014) Yoshimasa Taniguchi et al.   JOURNAL OF NATURAL PRODUCTS

A Novel 3,9-(1,2,3-Trioxocine)-Type Steroid of Rauia nodosa (Rutaceae)

(2014) Michelle Rocha et al.   MOLECULES

Naturally occurring bioactive Cyclobutane-containing (CBC) alkaloids in fungi, fungal endophytes, and plants

(2014) Valery M. Dembitsky   PHYTOMEDICINE

Epoxy acetylenic lipids: Their analogues and derivatives

(2014) Dmitry V. Kuklev et al.   PROGRESS IN LIPID RESEARCH

Metalloantimalarials

(2013) Paloma F. Salas et al.   CHEMICAL REVIEWS

Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic FungusAspergillus nigerMA-132

(2013) Dong Liu et al.   HELVETICA CHIMICA ACTA

Further mulinane diterpenoids fromAzorella compacta

(2013) Carlos Areche et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Protostane and Fusidane Triterpenes: A Mini-Review

(2013) Ming Zhao et al.   MOLECULES

Bioactive acetylenic metabolites

(2013) Dmitry V. Kuklev et al.   PHYTOMEDICINE

ASCARIDOLE AND RELATED PEROXIDES FROM THE GENUS CHENOPODIUM

(2012) Valery Dembitsky et al.   BIOMEDICAL PAPERS-OLOMOUC

Boron Containing Compounds as Protease Inhibitors

(2012) Reem Smoum et al.   CHEMICAL REVIEWS

Secondary Metabolites from an Algicolous Aspergillus versicolor Strain

(2012) Feng-Ping Miao et al.   Marine Drugs

Sesquiterpenoids from Curcuma wenyujin with anti-influenza viral activities

(2012) Jian-Yong Dong et al.   PHYTOCHEMISTRY

A novel eudesmene sesquiterpenoid from Schisandra sphenanthera stems

(2011) Wen-Hui Ma et al.   CHEMISTRY OF NATURAL COMPOUNDS

The multiple nutrition properties of some exotic fruits: Biological activity and active metabolites

(2011) Valery M. Dembitsky et al.   FOOD RESEARCH INTERNATIONAL

A New Peroxy-multiflorane Triterpene Ester from the Processed Seeds of Trichosanthes kirilowii

(2011) Yue-Ping Ma et al.   HELVETICA CHIMICA ACTA

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

(2011) Maria P. Crespo-Ortiz et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Antiangiogenic Effect of Chamigrane Endoperoxides from a Thai Mangrove-Derived Fungus

(2011) Supichar Chokpaiboon et al.   JOURNAL OF NATURAL PRODUCTS

Cytotoxic Norsesquiterpene Peroxides from the Endophytic FungusTalaromyces flavusIsolated from the Mangrove PlantSonneratia apetala

(2011) Hanxiang Li et al.   JOURNAL OF NATURAL PRODUCTS

Isolation and Confirmation of the Proposed Cleistanthol Biogentic Link fromCroton insularis

(2011) Lidia A. Maslovskaya et al.   ORGANIC LETTERS

Structural Reassignment of Cytosporolides A–C via Biomimetic Synthetic Studies and Reinterpretation of NMR Data

(2011) Justin T. J. Spence et al.   ORGANIC LETTERS

Nitrogenous sesquiterpenes from the Thai marine sponge Halichondria sp.

(2011) Hunsa Prawat et al.   TETRAHEDRON

Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity

(2010) Yan Ding et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Polyprenylated Benzoylphloroglucinol-Type Derivatives Including Novel Cage Compounds from Hypericum erectum

(2010) Yohei Ishida et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Natural and Synthetic Small Boron-Containing Molecules as Potential Inhibitors of Bacterial and Fungal Quorum Sensing

(2010) Valery M. Dembitsky et al.   CHEMICAL REVIEWS

Pro-apoptotic activity of ergosterol peroxide and (22E)-ergosta-7,22-dien-5α-hydroxy-3,6-dione in human prostate cancer cells

(2010) A. Russo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Prenylated Benzophenone Peroxide Derivatives fromHypericum sampsonii

(2010) Zhi Yong Xiao et al.   CHEMISTRY & BIODIVERSITY

Two new chamigrane metabolites from fermentation broth of Steccherinum ochraceum

(2010) Dong-Ze Liu et al.   FITOTERAPIA

Cytotoxic Nor-chamigrane and Chamigrane Endoperoxides from a Basidiomycetous Fungus

(2010) Supichar Chokpaiboon et al.   JOURNAL OF NATURAL PRODUCTS

Cytosporolides A−C, Antimicrobial Meroterpenoids with a Unique Peroxylactone Skeleton fromCytosporasp.

(2010) Yan Li et al.   ORGANIC LETTERS

Schinalactone A, a New Cytotoxic Triterpenoid fromSchisandra sphenanthera

(2010) Fei He et al.   ORGANIC LETTERS

Two novel norsesquiterpene peroxides from basidiomycete Steccherinum ochraceum

(2010) Dong-Ze Liu et al.   TETRAHEDRON LETTERS

Synthesis of triterpenoid-based 1,2,4-trioxolanes and 1,2,4-dioxazolidines by ozonolysis of allobetulin derivatives

(2010) Oxana B. Kazakova et al.   TETRAHEDRON LETTERS

Unique metabolites of Pestalotiopsis fici suggest a biosynthetic hypothesis involving a Diels–Alder reaction and then mechanistic diversification

(2009) Ling Liu et al.   CHEMICAL COMMUNICATIONS

Chemistry and Biology of Synthetic and Naturally Occurring Antiamoebic Agents†

(2009) Shailendra Singh et al.   CHEMICAL REVIEWS

Aziridine alkaloids as potential therapeutic agents

(2009) Fyaz M.D. Ismail et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Plasmalogens, fatty acids and alkyl glyceryl ethers of marine and freshwater clams and mussels

(2009) Lumír O. Hanuš et al.   FOOD CHEMISTRY

Terpenes fromEupatorium adenophorumand Their Allelopathic Effects onArabidopsisSeeds Germination†

(2009) Xu Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cytotoxic Activities of 9,11-Dehydroergosterol Peroxide and Ergosterol Peroxide from the Fermentation Mycelia ofGanoderma lucidumCultivated in the Medium Containing Leguminous Plants on Hep 3B Cells

(2009) Yu-Kuo Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Acetylenic Anticancer Agents

(2008) A. Siddiq et al.   Anti-Cancer Agents in Medicinal Chemistry

ent-Kaurane Diterpenoids from the LiverwortJungermannia atrobrunnea

(2008) Jian-Bo Qu et al.   JOURNAL OF NATURAL PRODUCTS

Antimicrobial Triterpenoids fromVladimiria muliensis

(2008) Jian-Jun Chen et al.   JOURNAL OF NATURAL PRODUCTS

Cadinane Sesquiterpenes from the Leaves ofEupatorium adenophorum

(2008) Lan He et al.   JOURNAL OF NATURAL PRODUCTS

Bioactive Diterpenes and Other Constituents ofCroton steenkampianus

(2008) Adeboye M. Adelekan et al.   JOURNAL OF NATURAL PRODUCTS

5α,8α-Epidioxysterols from the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum: Isolation and evaluation of their antiproliferative activity

(2008) Efstathia Ioannou et al.   STEROIDS

Bioactive peroxides as potential therapeutic agents

(2007) Valery M. Dembitsky   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY