Article
Chemistry, Organic
Wei-Hua Jiao, Jia-Xin Li, Hong-Yan Liu, Xiang-Chao Luo, Tian-Yong Hu, Guo-Hua Shi, Dong-Dong Xie, Hai-Feng Chen, Bao-Hui Cheng, Hou-Wen Lin
Summary: An unusual secomeroterpenoid, dysambiol (1), was isolated from a Dysidea sp. marine sponge collected from the South China Sea. Dysambiol features an unprecedented secomeroterpene scaffold with a rare lactone bridge. Dysambiol displayed potent anti-inflammatory activity in LPS-induced Raw 264.7 macrophages by regulating the NF-κB/MPAK signaling pathway.
Article
Plant Sciences
Meng Bai, Cai-Juan Zheng, Guang-Ying Chen
Summary: Three unusual austins-type meroterpenoids were isolated from a mangrove-derived fungus, each with unique structural features. These compounds showed inhibitory effects on the growth of Helicoverpa armigera larvae.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Plant Sciences
Jin-Ling Chang, Yu-Tian Gan, Xiao Gang Peng, Qian-Xi Ouyang, Jiao Pei, Han-Li Ruan
Summary: Five new meroterpenoids, Peniandranoids A-E (1-5), along with three known analogues (6-8), were isolated from the fermentation of a soil-derived fungus, Penicillium sp.sb62. The structures and absolute configurations of these compounds were determined by extensive spectroscopic analysis, with the absolute configurations of compounds 1 and 5 further confirmed by single-crystal X-ray diffraction. Peniandranoids A-E are a rare class of andrastin-type meroterpenoids that incorporate an extra polyketide unit, with compound 1 and 2 containing a C10 polyketide unit, compound 3 and 4 containing a C9 polyketide unit, and compound 5 containing a furancarboxylic acid unit. Compound 1 and 6 showed favorable inhibitory activities against influenza virus A (H1N1) with EC50 values of 19 and 14 μg/mL, respectively. Compounds 3-8 exhibited potent immunosuppressive activities against concanavalin A-induced T cell proliferation with EC50 values ranging from 4.3 to 27 μM and lipopolysaccharide-induced B cell proliferation with EC50 values ranging from 7.5 to 23 μM, respectively.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Multidisciplinary
Hai-Wei Yan, Rong-Rong Du, Xu Zhang, Ya-Nan Yang, Xiang Yuan, Zi-Ming Feng, Jian-Shuang Jiang, Pei-Cheng Zhang
Summary: Arnequinol A and arnequinone A were isolated from Arnebia euchroma and their structures were determined using spectroscopic methods and quantum chemical calculations. Compound 2 showed potent neuroprotective activity in vitro.
CHINESE CHEMICAL LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Jinling Chang, Qianxi Ouyang, Xiaogang Peng, Jiao Pei, Linlin Zhang, Yutian Gan, Hanli Ruan
Summary: Eight new andrastin-type meroterpenoids, named peniandrastins A-H (1-8), were isolated from the fermentation of soil-derived fungus Penicillium sp.sb62, along with six known analogues (9-14). The structures and absolute configurations were determined by spectroscopic data and X-ray diffraction analysis. Compound 1-4 belong to a rare class of 21-nor-andrastin meroterpenoids, while compounds 5-8 are C25 andrastin-type meroterpenoids. All compounds were evaluated for their immunosuppressive activities and the structure-activity relationships were discussed.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yuqian Tang, Xiaocong Chen, Yuwei Zhou, Min Zhao, Jingxin He, Yena Liu, Guangying Chen, Zhongxiang Zhao, Hui Cui
Summary: Furanaspermeroterpenes A and B, along with five new congeners, were isolated from the marine-derived fungus Aspergillus terreus GZU-31-1. Compound 3, with a unique pentacyclic structure, exhibited significant anti-inflammatory activity in bioassays.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Tu-Xiang Mo, Xi-Shan Huang, Wen-Xiu Zhang, Till F. Schaeberle, Jiang-Ke Qin, De-Xiong Zhou, Xiao-Ya Qin, Zhao-Long Xu, Jun Li, Rui-Yun Yang
Summary: Five new meroterpenoids were isolated from the fungus Penicillium sp. GDGJ-285 using MS/MS based molecular networking, including three novel skeleton meroterpenoids and two new isoaustinone analogues. The structures were determined by HRMS, NMR spectroscopy, and X-ray single-crystal diffraction analysis. Compound 3 showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophage cells with an IC50 value of 39.03 mu M.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Biochemistry & Molecular Biology
Tao Chen, Yufeng Liu, Yun Huang, Wencong Yang, Bing Sun, Qi Tan, Tianyu Wei, Bo Wang, Jie Yuan, Zhigang She
Summary: Ten new meroterpenoids and ten known analogues were isolated from a mangrove-associated fungus. Their structures and absolute configurations were determined through various analysis methods. Four compounds exhibited cytotoxicity against multiple cancer cell lines.
Article
Chemistry, Medicinal
Min-Ji Ryu, Prima F. Hillman, Jihye Lee, Sunghoon Hwang, Eun-Young Lee, Sun-Shin Cha, Inho Yang, Dong-Chan Oh, Sang-Jip Nam, William Fenical
Summary: New chlorinated meroterpenoids were obtained from a bacterium strain isolated from marine sediment, with compound 3 showing strong antibacterial activities against specific strains.
Article
Chemistry, Medicinal
Jinwei Ren, Ruiyun Huo, Gaoran Liu, Ling Liu
Summary: Three new andrastin-type meroterpenoids, penimeroterpenoids A-C (1-3), along with two known analogs, were isolated from the cultures of marine-derived Penicillium species. The structures of the new compounds were identified through NMR and mass spectrometry, while the absolute configurations were determined using experimental and calculated ECD spectra. Compound 1 exhibited moderate cytotoxicity against A549, HCT116, and SW480 cell lines.
Article
Chemistry, Multidisciplinary
Shuanggang Ma, Rubing Wang, Rongmei Gao, Xiaojing Wang, Yunbao Liu, Yong Li, Li Li, Yuhuan Li, Jing Qu, Shishan Yu
Summary: Two unprecedented polycyclic spirooliganones C and D with a novel carbon skeleton were isolated from the roots of Illicium oligandrum. Their structures and absolute configurations were determined, and a possible biosynthetic pathway was proposed. These compounds exhibited significant antiviral activity, showing potential as antiviral agents.
CHINESE CHEMICAL LETTERS
(2022)
Article
Multidisciplinary Sciences
Evgeny Ilyukhin, Hai D. T. Nguyen, Alan J. Castle, Walid Ellouze
Summary: A new species of Cytospora, named Cytospora paraplurivora sp. nov., was isolated from cankered wood of Prunus spp. in southern Ontario, Canada. This species has the potential to severely affect stone fruits production, causing cankers and dieback in stressed trees, and is pathogenic to Prunus persica var. persica. Phylogenomic analysis confirms its classification within the family Cytosporaceae of Diaporthales.
Article
Plant Sciences
Changyan Li, Yating Shao, Wei Li, Tianpeng Yin, Hongtao Li, Hui Yan, Xingyi Guo, Bo Liu, Bo He
Summary: Cultivation of an endophytic fungus with a histone deacetylase inhibitor resulted in the isolation of new diterpenic meroterpenoids with unique natural product framework and moderate activity.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Medicinal
Jian-Fa Zong, Meng-Meng Zhang, Yu-Bo Zhou, Jia Li, Ai-Jun Hou, Chun Lei
Summary: Three new polyprenylated acylphloroglucinol meroterpenoids, hyperiforins A-C, were isolated from Hypericum forrestii, along with twelve known analogues. Among them, compounds 1, 2, 5, 7, and 13-15 exhibited potent inhibitory effects on protein tyrosine phosphatase 1B with IC50 values ranging from 6.63 +/- 2.40 to 14.21 +/- 3.51 μM.
Article
Plant Sciences
Karen Harms, Pathompong Paomephan, Thitiya Boonpratuang, Rattaket Choeyklin, Chuenchit Boonchird, Frank Surup
Summary: Metabolites 1 and 2 isolated from mycelia collected in a tropical forest in northeastern Thailand showed activity against bacteria and cancer cells. Their chemical structures were identified through detailed analysis.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Plant Sciences
Ting Yang, Yi Xin, Tongyao Liu, Zhengfeng Li, Xingzhong Liu, Yunpeng Wu, Mingfeng Wang, Meichun Xiang
Summary: This study identified a rhizosphere bacterium, strain NC1, which showed strong inhibition against root-knot nematodes. Gas chromatography-mass spectrometry analysis revealed that the strain produced volatile compounds, DMDS and benzaldehyde, that exhibited nematicidal activity. A greenhouse trial demonstrated that the strain effectively controlled root-knot nematodes.
Review
Mycology
Bingjie Liu, Rong Fu, Bing Wu, Xingzhong Liu, Meichun Xiang
Summary: Rock-inhabiting fungi (RIF) are a group of organisms associated with terrestrial rocks, exhibiting unique morphological features and slow growth, which are significant in eukaryotic biology, ecology, and biotechnology. Understanding the biodiversity, antistress biology, origin, and convergent evolution of RIF can aid in cultural relic preservation and the application of biotechnology.
MYCOLOGY-AN INTERNATIONAL JOURNAL ON FUNGAL BIOLOGY
(2022)
Article
Mycology
Wenjia Li, Jing Li, Xuefeng Hu, Linghua Xu, Xiaoyu Liu, Zhengming Qian, Liling Jin, Yimin Zhang, Jiangchun Wei, Xingzhong Liu
Summary: Chinese cordyceps extract (CCE) has been found to exhibit anti-tumor effects through the suppression of tumor angiogenesis, making it a potential treatment for angiogenesis-related cancers.
MYCOLOGICAL PROGRESS
(2022)
Article
Microbiology
Meichun Xiang, Jun Chu, Wenjiao Cai, Haikun Ma, Weijing Zhu, Xiaoling Zhang, Jinwei Ren, Lizheng Xiao, Dongbo Liu, Xingzhong Liu
Summary: This study tracked microbial succession and interactions during the development of the golden flower fungus in Fu Brick tea using culture-dependent methods and high-throughput sequencing. The study found that the presence of the golden flower fungus was associated with microbes such as Klebsiella, Lactobacillus, and Bacillus, highlighting the importance of these co-occurring microbes in the manufacturing process of Fu Brick tea.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Zongkui Wang, Huiwen Xiao, Jiali Dong, Yuan Li, Bin Wang, Zhiyuan Chen, Xiaozhou Zeng, Jia Liu, Yanxi Dong, Li Ma, Jun Xu, Lu Cheng, Changqing Li, Xingzhong Liu, Ming Cui
Summary: Intravenous immunoglobulin (IVIg) has been investigated as a potential treatment for radiation injuries. The results showed that IVIg can protect against radiation-induced hematopoietic and gastrointestinal toxicity in female mice but not in males. In addition, IVIg can modulate gut microbiota configurations in both females and males. Overall, IVIg shows potential as a sex-specific therapeutic avenue to improve the prognosis of cancer patients undergoing radiotherapy.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Microbiology
Xiaozhou Zhao, Yani Fan, Meichun Xiang, Seogchan Kang, Shunxian Wang, Xingzhong Liu
Summary: The Ca2+/calmodulin-dependent signaling pathway plays critical roles in regulating growth, conidiation, and stress response in nematode-trapping fungi. The deletion of the Crz1 gene (DdaCrz1) in Drechslerella dactyloides significantly reduced hyphal growth and trap formation, and altered sensitivity to various ions and stress conditions. This study highlights the importance of the Ca2+/calmodulin-dependent signaling pathway in trapping nematodes.
Article
Microbiology
Yue Chen, Jia Liu, Yani Fan, Meichun Xiang, Seogchan Kang, Dongsheng Wei, Xingzhong Liu
Summary: DdVam7 protein plays a crucial role in D. dactyloides, regulating fungal growth, conidiation, and predatory process by mediating vacuole assembly, providing a basis for studying mechanisms of NTF and ring cell rapid inflation.
MICROBIOLOGY SPECTRUM
(2022)
Article
Plant Sciences
Peinan Fu, Yang Zhang, Chenyin Wang, Shuyi Si, Xingzhong Liu, Yongsheng Che
Summary: Four new 9,11-secosteroid-derived gamma-lactones, called Altersteroids A-D (1-4), were isolated from a culture of the ascomycete fungus Alternaria sp. Their structures were determined primarily by NMR experiments. The absolute configuration of compound 1 was established through X-ray crystallographic analysis, while the configurations of compounds 2-4 were assigned using quantum-chemical calculations. These compounds feature a gamma-lactone moiety fused to the steroid D ring at C13/C-14. Compound 3 exhibited moderate cytotoxicity against four tumor cell lines and induced apoptosis in A549 cells. Notably, compound 3 showed equipotent activity against cisplatin-sensitive and cisplatin-resistant MB49 cells, with an IC50 value of 12.7 μM.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Plant Sciences
Yang Zhang, Peinan Fu, Yiqing Zhang, Yang Xu, Chunyan Zhang, Xingzhong Liu, Yongsheng Che
Summary: In this study, two new xanthone derivatives, Cladoxanthones A and B, as well as a known compound, mangrovamide J, were isolated from the culture of Cladosporium sp. The structures and absolute configurations were determined using NMR and X-ray crystallography. These compounds exhibited weak cytotoxic effects.
JOURNAL OF NATURAL PRODUCTS
(2022)
Correction
Biology
Wenjia Li, Jinming Xia, Quanping Li, Zongyao Zhang, Weiwei Zhang, Caihong Dong, Jiangchun Wei, Xingzhong Liu
Summary: This paper contains errors in the authors' affiliations. Wenjia Li is a Ph.D. candidate at the University of Chinese Academy of Sciences, while Jiangchun Wei and Xingzhong Liu are professors at the same university, which was missing in the original version. The affiliations have been corrected.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Review
Mycology
Shunxian Wang, Xingzhong Liu
Summary: This paper summarizes the development and progress of gene manipulation tools in nematode-trapping fungi (NTF), including transformation methods and strategies, random gene mutagenesis methods, and target gene mutagenesis methods. It provides a clear reference and instruction for researchers working on NTF as well as other groups of fungi.
MYCOLOGY-AN INTERNATIONAL JOURNAL ON FUNGAL BIOLOGY
(2023)
Article
Mycology
Jingzu Sun, Shuang Yu, Yongzhong Lu, Hongwei Liu, Xingzhong Liu
Summary: During a field survey, two causal agents of mushroom diseases - Diploospora longispora and Paecilomyces penicillatus - were identified, causing up to 80% of yield losses. Phylogenetic analysis revealed that these fungi belong to a distinct clade in Hypocreales. Two new genera, Pseudodiploospora and Zelopaecilomyces, were introduced based on their morphological characteristics and phylogenetic relationships. Five new combinations were proposed.
MYCOLOGY-AN INTERNATIONAL JOURNAL ON FUNGAL BIOLOGY
(2023)
Article
Genetics & Heredity
Xiaozhou Zhao, Yani Fan, Weiwei Zhang, Meichun Xiang, Seogchan Kang, Shunxian Wang, Xingzhong Liu
Summary: Calcium ion (Ca2+) serves as a universal second messenger in regulating various processes in animals, plants, and fungi. The low-affinity calcium uptake system (LACS) is responsible for acquiring Ca2+ from the extracellular environment under high extracellular Ca2+ concentration. Nematode-trapping fungi (NTF) encode two related proteins for LACS, and this study focused on characterizing the role of DhFIG_2, an ortholog of AoFIG_2, in growth and development of Dactylellina haptotyla. Knocking down the expression of DhFIG_2 via RNA interference (RNAi) significantly impacted conidiation, trap formation, vegetative growth, and stress responses, indicating the importance of this LACS component in NTF.
FUNGAL GENETICS AND BIOLOGY
(2023)
Article
Chemistry, Medicinal
Wenjia Li, Qinggui Lei, Wenqing Li, Guoying Tan, Xingzhong Liu, Zhengming Qian
Summary: A high-performance liquid chromatography (HPLC) method using one reference compound was developed for the determination of 4 nucleosides in Chinese cordyceps. The method involved ultrasonic extraction of the cordyceps sample with a 0.5% phosphoric acid solution, followed by separation on a CORTECS T3 column using acetonitrile and water as the mobile phase. The established HPLC method showed good accuracy, precision, reproducibility, and stability, making it suitable for the quantitative analysis of nucleosides in Chinese cordyceps. The method is a simple, cost-effective, and time-saving alternative for quality control of Chinese cordyceps.
NATURAL PRODUCT COMMUNICATIONS
(2023)
Correction
Chemistry, Analytical
Wenjia Li, Zhengming Qian, Chunhong Li, Dean Guo, Jiangchun Wei, Xingzhong Liu
ANALYTICAL LETTERS
(2022)
