High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

(2020) Andrew S. Mendiola et al.   NATURE IMMUNOLOGY

Endoplasmic reticulum stress: New insights into the pathogenesis and treatment of retinal degenerative diseases

(2020) Marina S. Gorbatyuk et al.   PROGRESS IN RETINAL AND EYE RESEARCH

KIT ligand protects against both light-induced and genetic photoreceptor degeneration

(2020) Huirong Li et al.   eLife

Ferrous but not ferric iron sulfate kills photoreceptors and induces photoreceptor-dependent RPE autofluorescence

(2020) Wanting Shu et al.   Redox Biology

Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism

(2020) Cristina Fernández-Mendívil et al.   Redox Biology

AAVcis-regulatory sequences are correlated with ocular toxicity

(2019) Wenjun Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Haploinsufficiency of GCP4 induces autophagy and leads to photoreceptor degeneration due to defective spindle assembly in retina

(2019) Zhigang Li et al.   CELL DEATH AND DIFFERENTIATION

AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells

(2018) Nina Meyer et al.   Autophagy

Peroxiredoxin 5 prevents iron overload-induced neuronal death by inhibiting mitochondrial fragmentation and endoplasmic reticulum stress in mouse hippocampal HT-22 cells

(2018) Dong Gil Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration

(2018) Todd McLaughlin et al.   Molecular Neurodegeneration

The mechanism of cone cell death in Retinitis Pigmentosa

(2018) Peter A. Campochiaro et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy

(2018) Dimitra Athanasiou et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Dosage thresholds and influence of transgene cassette in AAV-related toxicity

(2018) Hanen Khabou et al.   HUMAN GENE THERAPY

Age-related macular degeneration

(2018) Paul Mitchell et al.   LANCET

The sinister face of heme oxygenase-1 in brain aging and disease

(2018) Hyman M. Schipper et al.   PROGRESS IN NEUROBIOLOGY

Parkinsonian features in aging GFAP.HMOX1 transgenic mice overexpressing human HO-1 in the astroglial compartment

(2017) Wei Song et al.   NEUROBIOLOGY OF AGING

Astrocyte heme oxygenase-1 reduces mortality and improves outcome after collagenase-induced intracerebral hemorrhage

(2017) Jing Chen-Roetling et al.   NEUROBIOLOGY OF DISEASE

MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress

(2017) Saumya Nagar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Epilation induces hair and skin pigmentation through an EDN3/EDNRB-dependent regenerative response of melanocyte stem cells

(2017) Huirong Li et al.   Scientific Reports

Heme Oxygenase-1 and Carbon Monoxide in the Heart

(2016) Leo E. Otterbein et al.   CIRCULATION RESEARCH

Heme Oxygenases in Cardiovascular Health and Disease

(2016) Anita Ayer et al.   PHYSIOLOGICAL REVIEWS

Alzheimer’s Disease: A Heme–Aβ Perspective

(2015) Chandradeep Ghosh et al.   ACCOUNTS OF CHEMICAL RESEARCH

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

The transcription factor X-box binding protein-1 in neurodegenerative diseases

(2014) Julie Dunys et al.   Molecular Neurodegeneration

Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration

(2014) C. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

(2014) M. Lu et al.   SCIENCE

New Insights into Intracellular Locations and Functions of Heme Oxygenase-1

(2013) Louise L. Dunn et al.   ANTIOXIDANTS & REDOX SIGNALING

Ablation of C/EBP Homologous Protein Does Not Protect T17M RHO Mice from Retinal Degeneration

(2013) Sonali Nashine et al.   PLoS One

Mitochondria-targeted heme oxygenase-1 induces oxidative stress and mitochondrial dysfunction in macrophages, kidney fibroblasts and in chronic alcohol hepatotoxicity

(2013) Seema Bansal et al.   Redox Biology

Role of endoplasmic reticulum stress in light-induced photoreceptor degeneration in mice

(2012) Tomohiro Nakanishi et al.   JOURNAL OF NEUROCHEMISTRY

Exacerbation of Oxidative Stress-Induced Cell Death and Differentiation in Induced Pluripotent Stem Cells Lacking Heme Oxygenase-1

(2011) Chen-Yu Lin et al.   STEM CELLS AND DEVELOPMENT

Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOP

(2009) Edward Thorp et al.   Cell Metabolism

The Parkinson disease-associated A30P mutation stabilizes α-synuclein against proteasomal degradation triggered by heme oxygenase-1 over-expression in human neuroblastoma cells

(2009) Wei Song et al.   JOURNAL OF NEUROCHEMISTRY

Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement

(2009) Hyman M. Schipper et al.   JOURNAL OF NEUROCHEMISTRY

HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues

(2009) Hillel Zukor et al.   JOURNAL OF NEUROCHEMISTRY