Haploinsufficiency of GCP4 induces autophagy and leads to photoreceptor degeneration due to defective spindle assembly in retina

Inhibiting autophagy reduces retinal degeneration caused by protein misfolding

(2018) Jingyu Yao et al.   Autophagy

Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality

(2017) Ge Li et al.   Cell Death & Disease

Nuclear autophagy: An evolutionarily conserved mechanism of nuclear degradation in the cytoplasm

(2016) Majing Luo et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Autophagy in the eye: Development, degeneration, and aging

(2016) Patricia Boya et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Mutations in TUBGCP4 Alter Microtubule Organization via the γ-Tubulin Ring Complex in Autosomal-Recessive Microcephaly with Chorioretinopathy

(2015) Sophie Scheidecker et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals

(2015) Jia Yuan et al.   Autophagy

Gene Essentiality Is a Quantitative Property Linked to Cellular Evolvability

(2015) Gaowen Liu et al.   CELL

Microtubule nucleation at the centrosome and beyond

(2015) Sabine Petry et al.   NATURE CELL BIOLOGY

Redefining gene essentiality

(2015) Liesbet Lieben   NATURE REVIEWS GENETICS

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet–Biedl syndrome

(2015) Poppy Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids

(2014) Mayurbhai Himatbhai Sahani et al.   Autophagy

Phosphoprotein of Human Parainfluenza Virus Type 3 Blocks Autophagosome-Lysosome Fusion to Increase Virus Production

(2014) Binbin Ding et al.   Cell Host & Microbe

γ-Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioning

(2014) Anaїs Bouissou et al.   EMBO JOURNAL

Long-Term Artificial Selection Reveals a Role of TCTP in Autophagy in Mammalian Cells

(2014) Ke Chen et al.   MOLECULAR BIOLOGY AND EVOLUTION

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

(2013) Kai Kaarniranta et al.   Autophagy

Nucleating New Branches from Old

(2013) Yixian Zheng et al.   CELL

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

(2013) Jacqueline K. White et al.   CELL

Noncanonical Autophagy Promotes the Visual Cycle

(2013) Ji-Young Kim et al.   CELL

Autophagy Protects the Retina from Light-induced Degeneration

(2013) Yu Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in Retinal Ganglion Cells in a Rhesus Monkey Chronic Hypertensive Glaucoma Model

(2013) Shuifeng Deng et al.   PLoS One

Oct4 Is Required ∼E7.5 for Proliferation in the Primitive Streak

(2013) Brian DeVeale et al.   PLoS Genetics

GCP6 is a substrate of Plk4 and required for centriole duplication

(2012) R. Bahtz et al.   JOURNAL OF CELL SCIENCE

DNA Demethylation and USF Regulate the Meiosis-Specific Expression of the Mouse Miwi

(2012) Yu Hou et al.   PLoS Genetics

Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice

(2011) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

Activation of Autophagy in a Rat Model of Retinal Ischemia following High Intraocular Pressure

(2011) Antonio Piras et al.   PLoS One

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

(2011) H. W. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells

(2011) Richard Marcotte et al.   Cancer Discovery

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait

(2010) Alan F. Wright et al.   NATURE REVIEWS GENETICS

Mechanisms of acute axonal degeneration in the optic nerve in vivo

(2010) J. Knoferle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of autophagy in retinal ganglion cells

(2008) Seok Hwan Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Highly parallel identification of essential genes in cancer cells

(2008) B. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profiling Essential Genes in Human Mammary Cells by Multiplex RNAi Screening

(2008) J. M. Silva et al.   SCIENCE

Cell cycle regulation during early mouse embryogenesis

(2007) Jérôme Artus et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY