Effects of cellular senescence on metabolic pathways in non-immune and immune cells

NMR-based metabonomic analysis of HUVEC cells during replicative senescence

(2020) Shenghui Yi et al.   Aging-US

Sestrins induce natural killer function in senescent-like CD8+ T cells

(2020) Branca I. Pereira et al.   NATURE IMMUNOLOGY

T-cell senescence contributes to abnormal glucose homeostasis in humans and mice

(2019) Hyon-Seung Yi et al.   Cell Death & Disease

NAD+ metabolism governs the proinflammatory senescence-associated secretome

(2019) Timothy Nacarelli et al.   NATURE CELL BIOLOGY

Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes after acute traumatic brain injury in mice

(2019) Rodney M. Ritzel et al.   NEUROBIOLOGY OF AGING

Age-related changes in B cell metabolism

(2019) Raj K. Kurupati et al.   Aging-US

Metabolic requirements of human pro-inflammatory B cells in aging and obesity

(2019) Daniela Frasca et al.   PLoS One

Reversal of epigenetic aging and immunosenescent trends in humans

(2019) Gregory M. Fahy et al.   AGING CELL

Proteome Oxidative Modifications and Impairment of Specific Metabolic Pathways During Cellular Senescence and Aging

(2019) Marie‐Paule Hamon et al.   PROTEOMICS

Mitochondrial mass governs the extent of human T cell senescence

(2019) Lauren A. Callender et al.   AGING CELL

Where Metabolism Meets Senescence: Focus on Endothelial Cells

(2019) Jacopo Sabbatinelli et al.   Frontiers in Physiology

Aging impairs mitochondrial respiratory capacity in classical monocytes

(2018) Brandt D. Pence et al.   EXPERIMENTAL GERONTOLOGY

Proteome oxidative carbonylation during oxidative stress-induced premature senescence of WI-38 human fibroblasts

(2018) Marine Le Boulch et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Second signals rescue B cells from activation-induced mitochondrial dysfunction and death

(2018) Munir Akkaya et al.   NATURE IMMUNOLOGY

Endothelial Cell Metabolism

(2018) Guy Eelen et al.   PHYSIOLOGICAL REVIEWS

CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions

(2018) Stephanie A. Amici et al.   Frontiers in Immunology

Endothelial cell senescence in aging-related vascular dysfunction

(2018) Guanghong Jia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis

(2018) Joanna Kalucka et al.   Cell Metabolism

The induction of the fibroblast extracellular senescence metabolome is a dynamic process

(2018) Emma N. L. James et al.   Scientific Reports

TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy

(2018) Lingyun Li et al.   Cell Metabolism

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

(2018) Paras S. Minhas et al.   NATURE IMMUNOLOGY

Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice

(2018) Noga Ron-Harel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways

(2017) Daniela Frasca et al.   EXPERIMENTAL GERONTOLOGY

Metabolic reprogramming of human CD8+memory T cells through loss of SIRT1

(2017) Mark Y. Jeng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolomics–Proteomics Combined Approach Identifies Differential Metabolism-Associated Molecular Events between Senescence and Apoptosis

(2017) Mengqiu Wu et al.   JOURNAL OF PROTEOME RESEARCH

Impaired energy metabolism of senescent muscle satellite cells is associated with oxidative modifications of glycolytic enzymes

(2016) Martín A. Baraibar et al.   Aging-US

From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence

(2016) Christopher D. Wiley et al.   Cell Metabolism

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients

(2016) Nele Claes et al.   JOURNAL OF IMMUNOLOGY

Hepatitis C viraemia reversibly maintains subset of antigen-specific T-bet+ tissue-like memory B cells

(2016) L.-Y. Chang et al.   JOURNAL OF VIRAL HEPATITIS

Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism

(2016) Emma L. James et al.   Scientific Reports

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation

(2015) T. Fulop et al.   BIOGERONTOLOGY

Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction

(2015) Claire A. Chougnet et al.   JOURNAL OF IMMUNOLOGY

Autophagy Controls Acquisition of Aging Features in Macrophages

(2015) Amanda J. Stranks et al.   Journal of Innate Immunity

Senescent Human Fibroblasts Show Increased Glycolysis and Redox Homeostasis with Extracellular Metabolomes That Overlap with Those of Irreparable DNA Damage, Aging, and Disease

(2015) Emma L. James et al.   JOURNAL OF PROTEOME RESEARCH

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response

(2015) Diana G. Adlowitz et al.   PLoS One

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

Trafficking phenotype and production of granzyme B by double negative B cells (IgG+IgD−CD27−) in the elderly

(2014) Matteo Bulati et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial Metabolism in T Cell Activation and Senescence: A Mini-Review

(2014) Noga Ron-Harel et al.   GERONTOLOGY

Double negative (CD19+IgG+IgD−CD27−) B lymphocytes: A new insight from telomerase in healthy elderly, in centenarian offspring and in Alzheimer's disease patients

(2014) Adriana Martorana et al.   IMMUNOLOGY LETTERS

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial Cell Senescence and Age-Related Vascular Diseases

(2014) Xiao-Li Tian et al.   Journal of Genetics and Genomics

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

(2014) A. Caro-Maldonado et al.   JOURNAL OF IMMUNOLOGY

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

(2013) Joel Crespo et al.   CURRENT OPINION IN IMMUNOLOGY

The role of mitochondria in aging

(2013) Ana Bratic et al.   JOURNAL OF CLINICAL INVESTIGATION

Sestrin 2 and AMPK Connect Hyperglycemia to Nox4-Dependent Endothelial Nitric Oxide Synthase Uncoupling and Matrix Protein Expression

(2013) Assaad A. Eid et al.   MOLECULAR AND CELLULAR BIOLOGY

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

A novel B cell population revealed by a CD38/CD24 gating strategy: CD38−CD24− B cells in centenarian offspring and elderly people

(2012) Silvio Buffa et al.   AGE

Oncogene-induced senescence results in marked metabolic and bioenergetic alterations

(2012) Celia Quijano et al.   CELL CYCLE

Oxidative proteome modifications target specific cellular pathways during oxidative stress, cellular senescence and aging

(2012) Martin A. Baraibar et al.   EXPERIMENTAL GERONTOLOGY

Chronic Exposure to Plasmodium falciparum Is Associated with Phenotypic Evidence of B and T Cell Exhaustion

(2012) J. Illingworth et al.   JOURNAL OF IMMUNOLOGY

Protein Oxidative Damage at the Crossroads of Cellular Senescence, Aging, and Age-Related Diseases

(2012) Martin A. Baraibar et al.   Oxidative Medicine and Cellular Longevity

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

(2011) Z. J. Reitman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

(2011) A. Safdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein modification and replicative senescence of WI-38 human embryonic fibroblasts

(2010) Emad K. Ahmed et al.   AGING CELL

Cellular senescence: putting the paradoxes in perspective

(2010) Judith Campisi   CURRENT OPINION IN GENETICS & DEVELOPMENT

Telomere/telomerase dynamics within the human immune system: Effect of chronic infection and stress

(2010) Rita B. Effros   EXPERIMENTAL GERONTOLOGY

Apoptosis Threshold Set by Noxa and Mcl-1 after T Cell Activation Regulates Competitive Selection of High-Affinity Clones

(2010) Felix M. Wensveen et al.   IMMUNITY

Akt Requires Glucose Metabolism to Suppress Puma Expression and Prevent Apoptosis of Leukemic T Cells

(2010) Jonathan L. Coloff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sustained CD28 Expression Delays Multiple Features of Replicative Senescence in Human CD8 T Lymphocytes

(2010) Stanley T. Parish et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Organization of GC/MS and LC/MS metabolomics data into chemical libraries

(2010) Corey D DeHaven et al.   Journal of Cheminformatics

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

CD28− T cells: their role in the age-associated decline of immune function

(2009) Nan-ping Weng et al.   TRENDS IN IMMUNOLOGY

Premature senescence of human endothelial cells induced by inhibition of glutaminase

(2008) Hermann Unterluggauer et al.   BIOGERONTOLOGY

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

(2008) Susan Moir et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

(2008) Nancie J. MacIver et al.   JOURNAL OF LEUKOCYTE BIOLOGY