Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis

Short- and long-term renal outcomes following severe rhabdomyolysis: a French multicenter retrospective study of 387 patients

(2020) Nelly Candela et al.   Annals of Intensive Care

Inflammaging and Complement System: A Link Between Acute Kidney Injury and Chronic Graft Damage

(2020) Rossana Franzin et al.   Frontiers in Immunology

Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation

(2020) Jin Y. Chen et al.   Frontiers in Immunology

Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis

(2020) Nicolas S. Merle et al.   Frontiers in Immunology

Hemopexin as an Inhibitor of Hemolysis-Induced Complement Activation

(2020) Victoria Poillerat et al.   Frontiers in Immunology

Glomerular membrane attack complex is not a reliable marker of ongoing C5 activation in lupus nephritis

(2019) Hannah R. Wilson et al.   KIDNEY INTERNATIONAL

The C5a/C5aR1 axis promotes progression of renal tubulointerstitial fibrosis in a mouse model of renal ischemia/reperfusion injury

(2019) Qi Peng et al.   KIDNEY INTERNATIONAL

Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates HDM-induced airway inflammation

(2019) Aiko Saku et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical promise of next-generation complement therapeutics

(2019) Dimitrios C. Mastellos et al.   NATURE REVIEWS DRUG DISCOVERY

Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury

(2018) Koshu Okubo et al.   NATURE MEDICINE

The multifaceted role of complement in kidney transplantation

(2018) Ali-Reza Biglarnia et al.   Nature Reviews Nephrology

Donor Urinary C5a Levels Independently Correlate With Posttransplant Delayed Graft Function

(2018) Bernd Schröppel et al.   TRANSPLANTATION

Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2

(2017) Sadam Yaseen et al.   FASEB JOURNAL

The emerging roles of mannose-binding lectin-associated serine proteases (MASPs) in the lectin pathway of complement and beyond

(2016) József Dobó et al.   IMMUNOLOGICAL REVIEWS

Complement-mediated ‘bystander’ damage initiates host NLRP3 inflammasome activation

(2016) Rahul Suresh et al.   JOURNAL OF CELL SCIENCE

Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury

(2016) Conrad A. Farrar et al.   JOURNAL OF CLINICAL INVESTIGATION

Heme: Modulator of Plasma Systems in Hemolytic Diseases

(2016) Lubka T. Roumenina et al.   TRENDS IN MOLECULAR MEDICINE

CD163-Macrophages Are Involved in Rhabdomyolysis-Induced Kidney Injury and May Be Detected by MRI with Targeted Gold-Coated Iron Oxide Nanoparticles

(2016) Alfonso Rubio-Navarro et al.   Theranostics

Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic Microangiopathy

(2015) K. A. Vernon et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury

(2015) Takanori Komada et al.   Scientific Reports

Renoprotective effect of long acting thioredoxin by modulating oxidative stress and macrophage migration inhibitory factor against rhabdomyolysis-associated acute kidney injury

(2015) Kento Nishida et al.   Scientific Reports

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4

(2014) Elham Asgari et al.   FASEB JOURNAL

Specific Macrophage Subtypes Influence the Progression of Rhabdomyolysis-Induced Kidney Injury

(2014) J. Belliere et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cutting Edge: The NLRP3 Inflammasome Links Complement-Mediated Inflammation and IL-1  Release

(2013) F. Laudisi et al.   JOURNAL OF IMMUNOLOGY

C3a and C5a Promote Renal Ischemia-Reperfusion Injury

(2012) Q. Peng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury

(2011) Brandon Renner et al.   KIDNEY INTERNATIONAL

Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure

(2010) Olivier Boutaud et al.   FREE RADICAL BIOLOGY AND MEDICINE

N-acetylcysteine attenuates glycerol-induced acute kidney injury by regulating MAPKs and Bcl-2 family proteins

(2009) J. H. Kim et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Rhabdomyolysis and Acute Kidney Injury

(2009) Xavier Bosch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endogenous Hepatocyte Growth Factor Attenuates Inflammatory Response in Glycerol-Induced Acute Kidney Injury

(2008) Eduardo Homsi et al.   AMERICAN JOURNAL OF NEPHROLOGY