Floxuridine Oligomers Activated under Hypoxic Environment

Carrier‐Free Delivery of Precise Drug–Chemogene Conjugates for Synergistic Treatment of Drug‐Resistant Cancer

(2020) Lijuan Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Prototyping kinase inhibitor-cytotoxin anticancer mutual prodrugs activated by tumour hypoxia: A chemical proof of concept study

(2019) Geraud N. Sansom et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Two-in-One Chemogene Assembled from Drug-Integrated Antisense Oligonucleotides To Reverse Chemoresistance

(2019) Quanbing Mou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzymatic activation of indolequinone-substituted 5-fluorodeoxyuridine prodrugs in hypoxic cells

(2019) Yota Jiho et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hypoxia-Activated PEGylated Conditional Aptamer/Antibody for Cancer Imaging with Improved Specificity

(2019) Fang Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Floxuridine Homomeric Oligonucleotides “Hitchhike” with Albumin In Situ for Cancer Chemotherapy

(2018) Cheng Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzymatic synthesis of nucleobase-modified single-stranded DNA offers tunable resistance to nuclease degradation

(2018) Renpeng Gu et al.   BIOMACROMOLECULES

Hypoxia-Triggered Transforming Immunomodulator for Cancer Immunotherapy via Photodynamically Enhanced Antigen Presentation of Dendritic Cell

(2018) Sooseok Im et al.   ACS Nano

Prodrug strategy for cancer cell-specific targeting: A recent overview

(2017) Xian Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of an Azo-Based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy

(2017) Wen Piao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biological applications of xeno nucleic acids

(2017) Kunihiko Morihiro et al.   Molecular BioSystems

Synthesis and Characterization of Cell-Permeable Oligonucleotides Bearing Reduction-Activated Protecting Groups on the Internucleotide Linkages

(2016) Hisao Saneyoshi et al.   BIOCONJUGATE CHEMISTRY

The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence

(2016) William H Gmeiner et al.   Future Oncology

Self-Immolative Spacers: Kinetic Aspects, Structure-Property Relationships, and Applications

(2015) Ahmed Alouane et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioreductive deprotection of 4-nitrobenzyl group on thymine base in oligonucleotides for the activation of duplex formation

(2015) Hisao Saneyoshi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hypoxia-Targeted siRNA Delivery

(2014) F. Perche et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of Azo-Based Fluorescent Probes to Detect Different Levels of Hypoxia

(2013) Wen Piao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hepatotoxic Potential of Therapeutic Oligonucleotides Can Be Predicted from Their Sequence and Modification Pattern

(2013) Peter H. Hagedorn et al.   Nucleic Acid Therapeutics

Reversible Off–On Fluorescence Probe for Hypoxia and Imaging of Hypoxia–Normoxia Cycles in Live Cells

(2012) Shodai Takahashi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Benzylidene Acetal Type Bridged Nucleic Acids: Changes in Properties Upon Cleavage of the Bridge Triggered by External Stimuli

(2011) Kunihiko Morihiro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Hypoxia-Sensitive Fluorescent Probes forin VivoReal-Time Fluorescence Imaging of Acute Ischemia

(2010) Kazuki Kiyose et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of a bioreductively-activated fluorescent pH probe for tumor hypoxia imaging

(2009) Eiji Nakata et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The design, synthesis and evaluation of hypoxia-activated pro-oligonucleotides

(2009) Nan Zhang et al.   CHEMICAL COMMUNICATIONS

Engineering Kinases to Phosphorylate Nucleoside Analogs for Antiviral and Cancer Therapy

(2009) Stefan Lutz et al.   CHIMIA

Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity

(2008) R. Sullivan et al.   MOLECULAR CANCER THERAPEUTICS